Sentences with phrase «in kinesin»

RESULTS: Here we report the identification of a de novo nonsense truncating mutation in one patient with SCZ, in kinesin 17, a synaptic motor protein.

Not exact matches

«Cell division: Physical forces involved in creating the mitotic spindle probed: The motor protein kinesin - 5 appears to help organize spindle's filaments by pushing or slowing them.»

The force exerted by kinesin - 5 in that process hasn't been previously measured.

To do the sorting, kinesin - 5 can link two anti-parallel microtubules, pushing them in opposite directions, so their minus ends move away from the spindle's center and toward the spindle's poles.

«We believe that kinesin - 5 has the ability to coordinate the speed of microtubules and keep them from going too fast or too slow,» says Forth, likening the protein to a gear box in a car.

Originally identified as a protein essential for mitosis in fungi, kinesin - 5 was first purified about 20 years ago by Scholey's lab who found that it is unusual because it has motor units at both ends, allowing it to link two microtubules and walk them past each other.

In this example, the leading kinesin (LK) carries most of the load, with motor heads (blue) activated by a neck linker (yellow) that connects to the stalk (red) and senses the presence of the cargo.

«The structure of kinesin - 5 is unexpected, and the implications are big — it allows us to target it, for example in various forms of cancer,» said Jawdat Al - Bassam, assistant professor of molecular and cellular biology at UC Davis, who led the project.

Functional analysis of human microtubule - based motor proteins, the kinesins and dyneins, in mitosis / cytokinesis using RNA interference.

A kinetoplastid - specific kinesin is required for cytokinesis and for maintenance of cell morphology in Trypanosoma brucei.

Inhibition of the motor protein Eg5 / Kinesin -5 in amyloid β - mediated impairment of hippocampal long - term potentiation and dendritic spine loss.

The human kinesin - 14 HSET tracks the tips of growing microtubules in vitro.

CENP - meta, an essential kinetochore kinesin required for the maintenance of metaphase chromosome alignment in Drosophila.

An orphan kinesin in trypanosomes cooperates with a kinetoplastid - specific kinesin to maintain cell morphology through regulating subpellicular microtubules.

Kinesins klp5 + and klp6 + are required for normal chromosome movement in mitosis.

A genomic toolkit to investigate kinesin and myosin motor function in cells.

Novel interactions of fission yeast kinesin 8 revealed through in vivo expression of truncation alleles.

Cerasela Dinu (Howard, MPG)-- «Leveraging the motor protein Kinesin to manipulate DNA molecules in synthetic environment» (2006)

Dense Core Vesicle Dynamics in Caenorhabditis elegans Neurons and the Role of Kinesin UNC - 104.

Marko Storch (Howard, MPG)-- «Characterization of microtubule stability regulating kinesins in vitro and introduction of a high throughput technique for studying kinesins on the single molecule level» (2012)

Tea2p is a kinesin - like protein required to generate polarized growth in fission yeast.

ARRY - 520, a novel selective kinesin spindle protein (KSP) inhibitor showed promising clinical activity both alone and combined with low - dose dexamethasone in a phase II clinical trial in patients with relapsed and refractory multiple myeloma.

In addition to receptors, GRIP has also been shown to bind to KIF - 5, a kinesin motor protein that is crucial in the transport of AMPA receptors within the neuron (Setou et al 2002In addition to receptors, GRIP has also been shown to bind to KIF - 5, a kinesin motor protein that is crucial in the transport of AMPA receptors within the neuron (Setou et al 2002in the transport of AMPA receptors within the neuron (Setou et al 2002).

As a graduate student at the European Molecular Biology Lab in Heidelberg he used cryo - EM to study kinesin motors, capturing snapshots that show how kinesin «walks» along a microtubule.

The investigators showed that kinesin movement corresponds to traffic from the center of a nerve cell to its axonal tips — and a different motor in the squid's cytoplasm, which was subsequently identified as dynein, travels in the opposite direction.