Sentences with phrase «in laboratory animals with»

Accelerate tumor growth — tumors grow two to three times faster in laboratory animals with severe sleep dysfunctions

(Tumors grow two to three times faster in laboratory animals with severe sleep dysfunctions)

Not exact matches

John Eppig, a reproductive biologist at Jackson Laboratory in Bar Harbor, Maine raised the concern that no animal studies with a control group have been done — a standard practice with experimental medical procedures — yet somehow the procedure is being tried on humans.

It is customary and even ethically mandatory that experimentation that carries with it a substantial degree of risk to human subjects first be tested in an animal laboratory or, at the very least, on a computer model.

The churches should align themselves with watchdog organizations that monitor the treatment of animals in laboratories in their own community.

Carrageenan is such an efficient inflammatory agent and carcinogen, it is widely used with laboratory animals to study the molecular signals involved in cancer and anti-inflammatory drugs.

«For 20 years this place has been a kind of laboratory for me, one where I could stay in touch with individual animals and accumulate information about them over a relatively long period.

AAAS Board Chairman Gilbert S. Omenn has written a letter to members of the House Judiciary Committee to express support for a pending bill that would strengthen laws against harassment, threats or intimidation of those involved in animal enterprises, including biomedical research with laboratory animals.

However, in some studies with laboratory mice, Feinberg had observed that these epigenetic tags varied considerably among the mice even when comparing the same type of tissue in animals that have been living in the exact same conditions.

When RCGD 423 was applied to joint cartilage cells in the laboratory, the cells proliferated more and died less, and when injected into the knees of rats with damaged cartilage, the animals could more effectively heal their injuries.

The virus, redesigned using sophisticated protein engineering techniques, works: With its shield and its adapter, these viral gene shuttles efficiently infected tumor cells in laboratory animals.

He anticipates that if the laboratory and animal studies continue to be positive, a study in children with the problem could be possible in the next two to three years.

They then induced Parkinson's symptoms in laboratory rats by killing the rodents» dopamine - producing neurons with toxins, and injected the viruses into the damaged tissue of some of the animals.

«All the sudden you can do these sorts of studies in scrub jays and other animals that are not a [laboratory] organism,» says Joseph Pickrell, an evolutionary geneticist at the New York Genome Center in New York City, who was not involved with the work.

Developmental biologist Francesca Peri of the European Molecular Biology Laboratory in Heidelberg, Germany, and colleagues created genetically engineered versions of the animals that produced microglia labelled with green fluorescent protein, a glowing compound frequently used in laboratoryLaboratory in Heidelberg, Germany, and colleagues created genetically engineered versions of the animals that produced microglia labelled with green fluorescent protein, a glowing compound frequently used in laboratorylaboratory research.

Franco believes that the new European legislation — which would require systematic evaluation of all research involving laboratory animals in all E.U. countries, with ethical considerations a big part of the assessment — makes now a good time «to assess what [researchers] think about using animals, what effect training can have not only about their knowledge of the three R's but also how it affects their attitudes.»

Most animal studies of the disease are conducted with laboratory mice that have been genetically engineered and bred to model ALS, but for this research, investigators used rats with ALS because they more accurately portray the disease's variable course in humans.

A few years ago, the sudden rise in anecdotal reports of these drugs» dangerous effects prompted Taffe and his TSRI colleague, chemist Associate Professor Tobin J. Dickerson, to set up studies with laboratory animals.

The drug as well as the physical contact of the microneedles with the scar tissue contributes to the efficacy of the device, leading to the cessation of scar tissue growth and a considerable reduction of keloids as demonstrated in laboratory cultures and experiments with animals.

«That suggests the problem lies with the immune response of the obese animals rather than the antibodies themselves,» said first author Erik Karlsson, Ph.D., a staff scientist in the Schultz - Cherry laboratory.

[That] fits with the idea that multicellularity evolved separately [in plants and animals],» says plant geneticist Robert Martienssen of the Cold Spring Harbor Laboratory in New York.

For example, it could be used to image neurons in living mice by combining the Raman scattering technique with existing methods in which tiny windows are implanted in the brains and spinal cords of laboratory animals.

In their research, scientists at Rutgers created animal models that closely resemble the cancerous tumors found in women with ovarian cancer by injecting tumor tissues obtained from gynecological cancer patients treated at the Cancer Institute into laboratory micIn their research, scientists at Rutgers created animal models that closely resemble the cancerous tumors found in women with ovarian cancer by injecting tumor tissues obtained from gynecological cancer patients treated at the Cancer Institute into laboratory micin women with ovarian cancer by injecting tumor tissues obtained from gynecological cancer patients treated at the Cancer Institute into laboratory mice.

Along with one of his graduate students, he has managed to re-create the tube worms» habitat in the laboratory, the first time anyone has managed to keep the animals alive for more than a few days away from the ocean.

A 2016 paper in Alternatives to Laboratory Animals concludes: «neuroscience would be more relevant and successful for humans if it were conducted with a direct human focus».

She finished her degree in biochemistry and went to work at a toxicology laboratory associated with the Pacific Northwest National Laboratory (PNNL) in Richland, Washington, analyzing chemicals tested olaboratory associated with the Pacific Northwest National Laboratory (PNNL) in Richland, Washington, analyzing chemicals tested oLaboratory (PNNL) in Richland, Washington, analyzing chemicals tested on animals.

According to the authors of the study, in future researches it will be necessary to know about the action mechanism of the new products - highly selective and with low cell toxicity on in vitro tests - and broaden preclinical studies with laboratory animal models.

It is the first study demonstrating that the extract protects against oral cancer, with the results of human, animal and laboratory tests reported in the journal Cancer Prevention Research.

However, the genetic techniques used to block Hhat in the laboratory are not possible with animal models or humans.

«Many studies — in laboratory animals and humans — have associated shorter telomeres with poor health outcomes, especially in adults,» said Eisenberg.

When tested in laboratory samples of leukemia cells and in animals with human - like leukemia, the approach caused cancer cells to die much more quickly than with conventional targeted therapies.

Newbury, in collaboration with Kathy Toohey - Kurth, virology section head at the Wisconsin Veterinary Diagnostic Laboratory, recently tested multiple cats at an animal shelter in Northwest Indiana and found them positive for the H3N2 canine influenza virus.

The researcher reminds us that the study of the modelling, organisation and coordination of the animal behaviour is a clear example of multidisciplinary collaboration: «biologists participate to perform the experiments in the laboratory and provide real data, in coordination with mathematicians and physicists who propose and solve the models.»

We thank Dr. Charles Mays and Marcelo Chacon in our laboratory for critical review and editing of the manuscript and Mrs. Andrea Flores for helping with maintaining and breeding animals for these experiments.

This study was carried out in strict accordance with the recommendations in the Guide for the Care and Use of Laboratory Animals of the National Institutes of Health.

BETHESDA, Md., Mon., Jan. 26, 2004 - A Japanese - U.S. team today reported the successful creation of transgenic animals using sperm genetically modified and grown in a laboratory dish, an achievement with implications for a wide range of research from developmental biology to gene therapy.

IDMIT is an infrastructure for preclinical research in infectious diseases and immunology which is certified ISO9001 and which includes 1) A large animal facility with capacity to host NHP in BSL2 and BSL3 containment, 2) State - of - the - art laboratories for cell biology, immunology, molecular biology, flow cytometry and mass cytometry (CyTof), cell - sorting and confocal microscopy in BSL3 containment; 3) A biological resources centre with high storage capacity; 4) Highly innovative technologies for in vivo imaging of large animals in BSL2 and BSL3 containment, including a two - photon microscope, a PET - CT facility, and several optic based technologies (fibered endo - microscopy, near infra - red imaging).

The BUAV have infiltrated several UK animal laboratories in 2013, however the video footage they have sent to newspapers has shown important scientific research done carefully and with animal welfare in mind.

Dr. Chartoff's Neurobiology of Motivated Behavior Laboratory, founded in 2009, investigates the molecular, biochemical, and cellular mechanisms underlying drug dependence and withdrawal using animal behavioral models with high relevance to the human condition.

For biologists in the laboratory, this is a way to probe a geneâ $ ™ s function by making an animal with its genes altered in a certain way.

Once this work is completed, a second stage is committed, in which researchers of I - Stem, in collaboration with specialists in animal models of diseases targeted by the therapeutic explore the effects of experimental transplantation of cells obtained laboratory.

The team has access to state - of - the - art laboratories and animal facilities with BSL2 and BSL3 containment, flow cytometry, cell sorting, histopathology and in vivo imaging (IVIS).

All services provided are in accordance with the National Legislation and the European Legal framework (on the protection of animals used for scientific purposes), as well as the current Guidelines of the Federation of European Laboratory Animal Science Associations - FELASA).

Where possible, we replace our animal experiments with in vitro models, such as organoids, reducing the number of laboratory animals.

It may be more important that the quality of the feed provided for animals in regulatory tests has to comply with legally binding Good Laboratory Practice regulations (GLP), which include regular analyses to demonstrate amongst other things that contamination with heavy metals, pesticides and other substances is kept below strict limits.

«How can we determine what the immune system is going to do, and then how can we control that response, not only with cells in the laboratory, but also in an animal or a patient.»

The animals were housed individually in polypropylene cages with wire mesh bottom, maintained at standard laboratory conditions of light (12 - h light / dark cycle), temperature and relative humidity.

The experiments were performed in compliance with «principles of laboratory animal care» (NIH publication no. 85 - 23, revised 1985).

All animal studies were carried out in strict accordance with the recommendations in the Guide for the Care and Use of Laboratory Animals of the National Institutes of Health.

The RECIPIENT agrees to use the MATERIAL in compliance with all applicable statutes and regulations, including, for U.S. RECIPIENTS, applicable U.S. Federal statutes and Public Health Service policies for the use and care of laboratory animals (see 7 USC 2131 et.