Sentences with phrase «in laboratory models»

But it's such a new way of thinking about it and we're getting really, really encouraging results in our laboratory models,» said Peter Brooks, a senior scientist with MMCRI.

Researchers have already successfully tested glaucoma gene therapy in laboratory models.

A new study shows that restoring the lipids that help keep lung tissue flexible and inflated can help slow disease progression in laboratory models of pulmonary fibrosis.

He said experiments are under way to test the two - drug combination in laboratory models of metastasis - prone prostate cancer, leading eventually to tests in mouse models.

In a previous study, investigators at the Cancer Institute showed that using a vaccine treatment for bladder and breast cancer tumors in laboratory models resulted in a reversal of the traditional immune blockade, as well as the development of tumor specific immunity throughout the body.

«We desperately need new therapies for this disease, and regenerative medicine approaches have shown great promise in laboratory models and in clinical trials for other conditions.»

Combining chemotherapy and birinapant significantly improved disease - free survival in laboratory models of human ovarian cancer compared to using either therapy alone.

Testing continues in laboratory models to better determine the VNN - 1 pathway's role in contributing to airway inflammation and hyper - responsiveness in asthma.

Precessional states in a laboratory model of the Earth's core.

«Our interest in the body's own (innate) immune system as the culprit began when we discovered that immune system agents become activated in a laboratory model of Huntington's Disease,» he says.

Not exact matches

In many dark energy models, we would expect to see significant effects on both laboratory and cosmological scales.

The machine - learning - based model by Medial EarlySign used data found in EHRs, such as laboratory tests results, demographics, medication, and diagnostic codes, to predict a patient's risk of experiencing renal dysfunction.

It is customary and even ethically mandatory that experimentation that carries with it a substantial degree of risk to human subjects first be tested in an animal laboratory or, at the very least, on a computer model.

The extreme cases of unambiguous wave and particle behaviour occur in mutually exclusive laboratory situations.7 As one physicist puts it, you may have to use a wave model on Mondays, Wednesdays and Fridays, and a particle model on Tuesdays, Thursdays, and Saturdays.

First there are experimental models which can actually be constructed and used in the laboratory.

For processing, seeds were de-hulled with an Impeller Husker (model FC2K; Yamamoto Co, Ltd, Yamagata - ken, Japan); seeds were subsequently polished in small batches for 30 s with an electric grain polisher (model «Pearlest;» Kett Electric Laboratory, Tokyo, Japan).

Some football helmet manufacturers suggest that players who wear their helmets - especially new models - may be at lower risk of concussion than those who wear competitors» models or older helmets, basing their claims on how well the new or newer helmets absorb and lessen some of the impact forces that cause concussion in biomechanical studies performed in the controlled environment of the laboratory.

The study provides what the authors say is good clinical evidence that helmet design can lower the risk of concussion, not in a laboratory, but in games and practices, by showing that a helmet model introduced in 2000 provides better protection against concussion than an older helmet employing 20 - year - old design technology.

The reliability and stability of these methods were described by Wu et al. 27 Illumina tag sequencing of the 16S rRNA gene V4 - V5 hypervariable region was performed at the Marine Biological Laboratory in Woods Hole, Massachusetts, using established methods.28, 29 Details of sequencing methods, quality control and filtering, and statistical modeling are presented in the eAppendix in the Supplement.

Study researchers Hélène Seroussi and Erik Ivins of NASA's Jet Propulsion Laboratory built a model of all the known melting and freezing under the ice in the region.

Human tissue grown in the laboratory offers a critical model for understanding the disease process.

Once women scientists sought role models in laboratories; perhaps it's men who require role models now: male scientists who embrace domesticity.

You have to be able to see something at the bedside and think of how you can address it in a model organism or some kind of detailed biochemistry experiment in the laboratory.

Using these cells, the team modeled the patients» neurons and blood - brain barrier in a laboratory dish.

The new model «came out of left field, but it's very original,» says materials scientist Graham Hubler of the Naval Research Laboratory in Washington, D.C., who saw ball lightning as a teenager during a thunderstorm in upstate New York 40 years ago.

A raft of studies in laboratory animals, molecular models and cancer patients suggest that pain drugs given during and after cancer surgery stimulate the growth and spread of certain tumors.

The model requires so many calculations that it could only be run once — even with more than a year of computer time at the Oak Ridge National Laboratory, in Tennessee.

In another example, Epstein's laboratory at NYU is working with the city's public health department to model potential outbreaks of Zika, a mosquito - borne virus that can lead to catastrophic birth defects.

The laboratories also collaborated to successfully prove that reversing a protein deficiency through gene therapy is effective in improving and stabilizing SMA in a large animal model.

«Where this model really shines is explaining the late emission,» says Chris Fryer of Los Alamos National Laboratory in New Mexico — one of the physicists who first proposed the burrowing black hole theory in the 1990s.

Amandine Aftalion from the Mathematics Laboratory in Versailles (CNRS / University of Versailles - Saint - Quentin - en - Yvelines) and Frédéric Bonnans from the Center of Applied Mathematics (CNRS / Inria / École polytechnique) have produced a mathematical model to optimize running, which could lead to personal e-coaching customized to each individual's physiological state.

The ability to make and study cubic ice in the laboratory could improve computer models of how clouds interact with sunlight and the atmosphere — two keys to understanding climate change, said Barbara Wyslouzil, project leader and professor of chemical and biomolecular engineering at The Ohio State University.

This realization «pushed one entire laboratory project in the direction of understanding the immunology of pregnancy as a model for immunity of cancer,» Markovic says.

In the laboratory, I could be alone and build things, although now I was building molecules instead of model cars.

Like its European model, SESAME was conceived in part to motivate the region's best and brightest to stay, or even to return from abroad; the laboratory should also create excitement and opportunity that will attract young students to science.

In the study, which included a series of laboratory experiments, field surveys and mathematical modeling, the presence of various species of dragonfly larvae reduced the infections in frogs caused by parasitic flatworms called trematodes, said Val Beasley, professor and head of the department of veterinary and biomedical sciences, Penn State, who worked with Rohr and whose research group collaborated with Lucinda Johnson, senior research associate and director of the Center for Water and the Environment, University of Minnesota Duluth, to complete the field studIn the study, which included a series of laboratory experiments, field surveys and mathematical modeling, the presence of various species of dragonfly larvae reduced the infections in frogs caused by parasitic flatworms called trematodes, said Val Beasley, professor and head of the department of veterinary and biomedical sciences, Penn State, who worked with Rohr and whose research group collaborated with Lucinda Johnson, senior research associate and director of the Center for Water and the Environment, University of Minnesota Duluth, to complete the field studin frogs caused by parasitic flatworms called trematodes, said Val Beasley, professor and head of the department of veterinary and biomedical sciences, Penn State, who worked with Rohr and whose research group collaborated with Lucinda Johnson, senior research associate and director of the Center for Water and the Environment, University of Minnesota Duluth, to complete the field study.

It's for this reason that it's important to understand the differences in responses between geoengineering experiments, said Ben Kravitz, a climate modeler at the Pacific Northwest National Laboratory who helps run the international Geoengineering Model Intercomparison Project.

But Chris Fryer, a theoretical astrophysicist at Los Alamos National Laboratory in New Mexico, says it is more likely that the standard afterglow model needs revision.

The scientists then tested three new mTOR inhibitors currently under development (pp242, AZD8055 and INK128) in combination with the chemotherapies AraC, Etoposide and Cisplatin to see how they affected laboratory lines of leukemia cells and mouse models of the disease.

«For the past 100 years the tendency and the trend has been to develop as consistent a model as possible, so every individual will respond the same way to the same challenges,» says Nadia Rosenthal, the scientific director at Jackson Laboratory in Bar Harbor, Maine.

The ability of the inorganic component of sea spray particles to take up water has been the focus of this international study where a large suite of well - controlled laboratory experiments have shown, for the first time, that the hygroscopicity of the inorganic component of sea spray is significantly lower than pure sodium chloride, a substance routinely used to describe their hygroscopicity in climate models.

We were very surprised based on the fact that previous models people used for planet formation suggested a much higher critical shock pressure,» says Richard Kraus, now a scientist at Lawrence Livermore National Laboratory and lead author on the paper published in March in Nature Geoscience.

Transparent eggs and fry are «ideal for getting light in and getting light out,» notes Eric Edsinger, who develops model organisms at the Marine Biological Laboratory in Woods Hole, Mass..

The team studied a simulated cloak capable of hiding a single frequency of green light, and modelled it moving at various speeds in a laboratory illuminated by that frequency.

Michael Thoennessen, a professor and associate director of the National Superconducting Cyclotron Laboratory (NCSL) at Michigan State University in East Lansing believes that mentors can help young scientists by modeling the costs and rewards of persistence.

However, in IBD patients and in mouse models of colitis, Enterobacteriaceae species grow uncontrollably, said Dr. Wenhan Zhu, co-lead author and a postdoctoral researcher in the Winter laboratory.

«Despite the low infection levels of mouse cells with oHSV, we were able to cause a delay in tumor growth in one of the cancer models and even cure many of the mice in a second model,» said first author Jennifer Leddon, who conducted much of the laboratory work during a research experience in the Center for Childhood Cancer and Blood Diseases.

As it matures, the authors wrote, it is moving «from laboratory - based experimental studies in model systems to a mature discipline that is yielding products that are being evaluated and used in the clinical domain.

«However, these studies were either carried out in the laboratory over short timescales or based on theoretical models.

«So our mathematical model is basically a framework, or model system, that brings order to this randomness and provides general biological insights that can be applied in the laboratory.»