(A) The total number of muscle fibers
in laminin - stained EDL muscle sections from IL - 15Ra — KO mice was greater compared with B6129 control.
(E) The total number of muscle fibers counted
in laminin - stained TA muscle sections from IL - 15Ra — KO mice was greater compared with B6129 control.
This form of muscular dystrophy results from a genetic defect
in laminin - α2.
Not exact matches
Go to google images and type
in «
Laminin».
Now they report recovering not just collagen — which conveys little evolutionary information because it is the same
in almost all animals — but also haemoglobin, elastin and
laminin, as well as cell - like structures resembling blood and bone cells.
They found very similar structural defects and
laminin - α4 was also found
in place of
laminin - α2
in the diseased muscle fibers.
«When animals with a
laminin - α2 defect express the two linkers, there was a significant improvement
in muscle structure and force and an increase
in body weight.
In these diseased muscles, which are unable to produce
laminin - α2, another
laminin takes over.
«
Laminins function as attractive chemical cues for haptotaxis of axonal growth cones,» explains NAIST Prof. Naoyuki Inagaki, whose lab studies how forces are generated
in the cellular microenvironment to create directed axonal migration.
Microscope images show that
in normal skin (left) the top layer, called the epidermis (purple
in bottom images), is fused to the dermis by
laminin 332 (green,
in top images) and other proteins.
Mutations
in the LAMB3 gene prevented the boy from making
laminin 332 protein (top middle, white dashed line indicates where the protein should be), which helps fuse skin layers together.
Their young patient had a severe form of the disease known as junctional EB, caused by a mutation
in a gene encoding part of the protein
laminin 332, which makes up a thin membrane just below the epidermis.
In an effort to provide broad protection against meningitis, the researchers are now developing a vaccine that would prevent the bacteria from recognizing the laminin receptor, according to Elaine Tuomanen, a leader of the study and a physician at St. Jude Children's Research Hospital in Memphis, Tennesse
In an effort to provide broad protection against meningitis, the researchers are now developing a vaccine that would prevent the bacteria from recognizing the
laminin receptor, according to Elaine Tuomanen, a leader of the study and a physician at St. Jude Children's Research Hospital
in Memphis, Tennesse
in Memphis, Tennessee.
Quantification of total fiber number from
laminin / DAPI - stained sections revealed a 28 % greater number of total muscle fibers
in EDL muscles and a 29 % greater number of total muscle fibers
in TA muscles from IL - 15Rα — KO mice compared with B6129 controls (Figure 6, A and E).
Cells were resuspended
in HEPES buffer containing the following (
in mm): 136 NaCl, 5.6 KCl, 1 MgCl2, 2.2 CaCl2, 11 glucose, 10 HEPES; pH adjusted to 7.4 with NaOH before plating on poly - d - lysine (0.02 mg / ml; BD Bioscience) and
laminin (0.02 mg / ml; Sigma - Aldrich)- coated coverslips.
The fragments revealed more evidence of collagen and suggested the presence of two proteins —
laminin and elastin — found
in the blood vessels of animals.
The alpha2 beta1 integrin, a receptor for collagens,
laminins, decorin, E-cadherin, as well as other ligands, has been implicated
in normal developmental, inflammatory, and oncogenic processes.
Laminin α4 (LAMA4) Expression Promotes Trophoblast Cell Invasion, Migration, and Angiogenesis and is Lowered
in Pre-Eclamptic Placentas.
Chongmague reveals an essential role for
laminin - mediated boundary formation
in chordate convergence and extension movements.
The surface - exposed outer - membrane protein ErpX was identified as having affinity for
laminin, and is the first
laminin - binding protein to be identified
in a Lyme disease spirochaete.
Biologically relevant
laminins enable mouse pancreatic islets
in vitro culture: expansion, phenotype maintenance and glucose - dependent insulin release.
BioLamina believes
in sharing knowledge - here you will find information available on all the
laminin cell culture applications.
Our
laminin cell culture matrices allow you to imitate the natural, cell - specific cell - matrix interaction
in vitro, leading to improved cell functionality
Laminin - 111 is important during early epithelial development and differentiation of the epiblast, and is commonly used as a general attachment protein
in cell culture.
Our
laminin cell culture matrices allow you to imitate the natural cell - matrix interaction
in vitro, leading to improved cell functionality
Laminin - 521 human stem cell matrix makes pluripotent stem cell culture easy
in a defined, xeno - free and biologically relevant cell culture system.
Laminin cultured cells arrange themselves
in lobule like structures, express MRP1 and MRP2 and are capable of biliary efflux and show significant effect on hepatocyte P450 enzyme metabolic activity.
and cultured
in 5 % O2 / 7 % CO2
in Bottenstein - Sato F12 medium with 10 ng / ml human recombinant basic fibroblast growth factor (Peprotech) on a substrate of 1 µg / cm2 fibronectin (Chemicon) and 0.5 µg / cm2
laminin (Invitrogen).
Rapid spreading and mature hemidesmosome formation
in HaCaT Keratinocytes induced by incubation with soluble
laminin - 5r.
For example, new combinations of domains
in death-fold domain proteins and
laminins possibly allow for the modification of protein interactions and pathways involved
in programmed cell death and cell adhesion, respectively (Supplementary Note 9.3), and the co-option of sponge -, eumetazoan - or bilaterian - specific architectures into novel functions.
Human fetal NSCs (ReNCell VM, Chemicon) were cultured on
laminin - coated dishes
in ReNcell maintenance medium (Chemicon)
in the presence of basic fibroblast growth factor 2 (bFGF2), following the manufacturer's instructions.
SCR055, Millipore, Inc)
in 24 - well culture dishes coated with poly - L - ornithine (20 µg / ml) and
laminin (5 µg / ml).
Laminin - 511 is a major component of the basement membrane, which is expressed
in early development of the embryo and can be used as a matrix for pluripotent (ES / iPS) stem cells, as it binds to integrin on cell surfaces.
The vaccinated Purdue dogs also developed autoantibodies to
laminin, which is involved
in many cellular activities including the adhesion, spreading, differentiation, proliferation and movement of cells.
The vaccinated, but not the non-vaccinated, dogs
in the Purdue studies developed autoantibodies to many of their own biochemicals, including fibronectin,
laminin, DNA, albumin, cytochrome C, cardiolipin and collagen.
Studies at Purdue University showed that canine vaccines grown
in calf serum caused antibodies to be made to many calf proteins including red blood cells; thyroid; DNA; connective tissue proteins such as collagen, fibronectin,
laminin, albumin, transferrin; and others.