Sentences with phrase «in large human population»

«What's particularly noteworthy about this work is we were able to present an integrative link from genetics, cell - and animal - based experiments, all the way up to clinical outcomes in large human population,» Liu said.

Once transferred into the human genome, however, these alleles became subject to natural selection, which was more effective in the larger human populations and has removed these gene variants over time.

Not exact matches

Last time I checked the largest population of humans are in Asia and by a large margin.

Indonesia has the largest Muslim population and it has experienced productive and peaceful times in the decade since the Bali Bombings, actively committed to redressing a long history of human rights abuse and repairing once - frayed bonds with modern neighbors like Australia and New Zealand.

In fact, the largest group, Christians, make up less than 1/3 of the human population.

For example, in addition to having higher levels of genetic diversity, populations in Africa tend to have lower amounts of linkage disequilibrium than do populations outside Africa, partly because of the larger size of human populations in Africa over the course of human history and partly because the number of modern humans who left Africa to colonize the rest of the world appears to have been relatively low (Gabriel et al. 2002).

fred The Bible said that at a time when the world's human population was only in the millions, and disease generally prevented about 30 % of all children from reaching adulthood, so having large families was a way of hedging your bet.

Hardin contends that human populations have similar cycles and that when we «interfere» in the cycle with indiscriminate famine relief and medical assistance, we sustain the increase and artificially postpone the «crash,» making it larger and more tragic in the end — a process which Hardin terms the «ratchet effect.»

In general, our ruling class no longer believes in those divine decrees of which human decrees are but a hint or shadow, and neither does a large and growing part of the populatioIn general, our ruling class no longer believes in those divine decrees of which human decrees are but a hint or shadow, and neither does a large and growing part of the populatioin those divine decrees of which human decrees are but a hint or shadow, and neither does a large and growing part of the population.

Its exactly the reason why we are in this position to begin with its the peoples fault and we are the people, unless your not a human you do nt fall into this really large population on this planet called earth.

It also witnessed large - scale societal and attitudinal changes, including the creation of a brilliantly vibrant civil society encompassing human rights groups, environmentalists, indigenous populations and religious interests, active and often strident in pursuit of their societal aims.

The larger lesson is that we are in a race everywhere to cut off the pathogen's access to human victims before it establishes a fast track in the local populations.

So far they have mapped the natural geologic stresses throughout Oklahoma and Texas — the states with the largest populations at risk from human - induced quakes — and have discovered that only a fraction of faults hold the potential to slip in the presence of moderate pressure increases.

If they were hunting horses on foot, they would have quickly depleted bands of horses in the vicinity of the villages and would have had to go farther afield to hunt — it wouldn't have been feasible or supported that large human population.»

Ten thousand years ago, at the dawn of the Neolithic era, the agricultural revolution began to yield vastly larger amounts of food from cultivated crops and livestock, allowing rapid growth in human populations.

Despite countless findings to the contrary, a large portion of the population doesn't believe that scientists agree on the existence of human - caused climate change, which affects their willingness to seek a solution to the problem, according to a 2011 study in Nature Climate Change.

in the May issue claims that biologists say the concept of race is biologically meaningless, presumably because «any large human population has about 85 percent as much genetic variation as the species as a whole.»

The elk population in Yellowstone is at the mercy of a much larger, human - altered ecosystem.

The human population size has historically been much larger, and this is important since selection is more efficient at removing deleterious variants in large populations.

Writing in a linked Comment, Dr Abraham Goorhuis and Professor Martin P Grobusch, Center of Tropical Medicine and Travel Medicine, University of Amsterdam, Amsterdam, Netherlands say: «An important prerequisite for the occurrence of large - scale epidemics is the presence of an immunologically naive human population.

The timing of this decline correlates with environmental changes associated with the onset of the last glacial cycle, the team reports, whereas archaeological evidence does not support the presence of large populations of humans in eastern Beringia until more than 15,000 years later.

He found higher rates of nest predation in small woodlots near human communities because these areas had higher populations of raccoons (Procyon lotor) and squirrels (Sciurus spp.) and few, if any, large predators, such as cougars and bobcats (Lynx rufus).

This «cumulative culture» is unique to humans, but it could only emerge in reasonably large populations.

He thinks this work will inspire other researchers with large databases of data on humans to look at how selection operates in populations.

Nevertheless, the need for historical language comparison is still vital: «In large parts of the world, like in New Guinea or South America, both the languages and the history of the human populations speaking them still remain crudely understudied,» says LisIn large parts of the world, like in New Guinea or South America, both the languages and the history of the human populations speaking them still remain crudely understudied,» says Lisin New Guinea or South America, both the languages and the history of the human populations speaking them still remain crudely understudied,» says List.

More recently, improved gene - sequencing technology and larger population studies have made it possible to detect gene variants that appear in only 1 percent of the human population.

Previous research suggests our ability to cooperate and exhibit empathy — both thought to be critical to human success — relied in part on the large brains of our hominin ancestors, relative to body size; and that selection against aggression within early human populations allowed us to thrive.

And in what might prove an enduring lesson in conservation, paleoecologists have shown that 20 out of 21 large mammals in India — from leopards to muntjac deer — have survived there for the past 100,000 years alongside one of the largest human populations on the planet.

However, in the southwestern Amazon — which hosted large pre-Columbian populations — about 30 % of the distribution of domesticated species stemmed from human activities.

But with no evidence of a large asymptomatic population so far, Kellam and his colleagues favor a second scenario: MERS evolved and diversified in animals and then infected humans on multiple occasions.

With the recent publication of a large data set of 763 microsatellite markers — short stretches of DNA that are repeated in the genome — from 53 populations in the Human Genome Diversity Project, evolutionary geneticists William Amos and Joe Hoffman of the University of Cambridge in the United Kingdom had enough genomic data to test both models.

Developing therapeutic cell populations from human ES cells will be far more demanding: cells will have to be stable, predictable, pure, have proven functionality, be nontumor - forming, and be «scalable» — capable of growing in very large numbers.

In fact, claims that size variation in Australopithecus and / or Paranthropus was larger than that in recent human populations include inferences on sexual dimorphism (Richmond and Jungers, 1995; Plavcan et al., 2005; Lockwood et al., 2007; but see Reno et al., 2003), whereas arguments referring to early Homo are usually associated with eco-physiological variants (Antón et al., 2014; Di Vincenzo et al., 2015In fact, claims that size variation in Australopithecus and / or Paranthropus was larger than that in recent human populations include inferences on sexual dimorphism (Richmond and Jungers, 1995; Plavcan et al., 2005; Lockwood et al., 2007; but see Reno et al., 2003), whereas arguments referring to early Homo are usually associated with eco-physiological variants (Antón et al., 2014; Di Vincenzo et al., 2015in Australopithecus and / or Paranthropus was larger than that in recent human populations include inferences on sexual dimorphism (Richmond and Jungers, 1995; Plavcan et al., 2005; Lockwood et al., 2007; but see Reno et al., 2003), whereas arguments referring to early Homo are usually associated with eco-physiological variants (Antón et al., 2014; Di Vincenzo et al., 2015in recent human populations include inferences on sexual dimorphism (Richmond and Jungers, 1995; Plavcan et al., 2005; Lockwood et al., 2007; but see Reno et al., 2003), whereas arguments referring to early Homo are usually associated with eco-physiological variants (Antón et al., 2014; Di Vincenzo et al., 2015).

In large organisms with relatively small population sizes, such as humans, only in the order of 1 % of the genomic information is shaped by the environment via natural selectioIn large organisms with relatively small population sizes, such as humans, only in the order of 1 % of the genomic information is shaped by the environment via natural selectioin the order of 1 % of the genomic information is shaped by the environment via natural selection.

Studying the severe drought in São Paulo, the largest city in South America with a population of about 20 million, a team led by Friederike Otto found that human - induced climate change was not a major influence.

We observed that East African populations exhibit a much larger degree of genetic diversity than other global groups, which further supports the Out - of - Africa theory (that postulates that modern humans originated in East Africa and migrated out of the continent to populate the world)» says Dr. Koehler.

«It might be difficult to imagine why the large number of gene variants that together give rise to traits like [autism spectrum disorder] are retained in human populations,» co-author and genetics and neuroscience professor Joel Gelernter said in a statement from Yale University.

In a paper published in Nature in September 2013, we describe results of the largest study to date integrating RNA and genome sequencing data from multiple human populations, and provide a comprehensive map of how genetic variation affects the transcriptomIn a paper published in Nature in September 2013, we describe results of the largest study to date integrating RNA and genome sequencing data from multiple human populations, and provide a comprehensive map of how genetic variation affects the transcriptomin Nature in September 2013, we describe results of the largest study to date integrating RNA and genome sequencing data from multiple human populations, and provide a comprehensive map of how genetic variation affects the transcriptomin September 2013, we describe results of the largest study to date integrating RNA and genome sequencing data from multiple human populations, and provide a comprehensive map of how genetic variation affects the transcriptome.

This may be relevant for understanding the evolution of the large human CMV - specific CD8 + T cell populations seen in humans.

SciLifeLab is the first IGN partner in Europe and will initiate a national large - scale population sequencing program seeking to identify genetic causes of human diseases.

This is particularly true in the case of persistent herpesviruses such as human CMV, which are typified by large virus - specific CD8 + T cell populations during viral latency.

A group of scientists at Stanford University have collaborated on a large study to understand genetic diversity in human populations.

But when a new mutation appears in a species with a relatively small population, as in large mammals and humans, selection against the error is slower and less efficient, allowing the mutation to spread through the population.

To this end, his work often relies on anthropology and human history as much as it does on genome sequencing and computation, in order to decipher the subtle genetic signatures that appear when species undergo major events such as population bottlenecks, large - scale migration or dispersal events, or the development of resistance to disease.

Metagenomics is the study of the sequences of large populations of different organisms all growing in a common environment - as for example seawater, soil, the human gut - and these studies are made vastly easier by next - generation sequencing.

David Reich and colleagues report genome sequences of 300 people from 142 different populations usually under - represented in large - scale studies to describe a range of human variation.

This species roams in large groups with complex social structures, and it is always difficult not to see some human - like qualities among these populations.

Table 1: Summary of Randomized Controlled Trials in Human Populations Looking at the Effects of IER on Indices of Cardiometabolic Health (Click image for larger view)

Humans have a large and varied population of beneficial bacteria that live in their intestines.

The delicate balance between the human microbiome and the development of psychopathologies is particularly interesting given the ease with which the microbiome can be altered by external factors, such as diet, 23 exposure to antimicrobials24, 25 or disrupted sleep patterns.26 For example, a link between antibiotic exposure and altered brain function is well evidenced by the psychiatric side - effects of antibiotics, which range from anxiety and panic to major depression, psychosis and delirium.1 A recent large population study reported that treatment with a single antibiotic course was associated with an increased risk for depression and anxiety, rising with multiple exposures.27 Bercik et al. 28 showed that oral administration of non-absorbable antimicrobials transiently altered the composition of the gut microbiota in adult mice and increased exploratory behaviour and hippocampal expression of brain - derived neurotrophic factor (BDNF), while intraperitoneal administration had no effect on behaviour.