Sentences with phrase «in larger numbers of patient»

«This study demonstrates the value of using the SEER database to analyze factors associated with surgery as a treatment for localized pancreatic cancer in a large number of patients over a prolonged period of time,» says Dr. Kim, who is also Chief Medical Officer of UH Seidman Cancer Center and the Charles Hubay Professor at Case Western Reserve School of Medicine.

In particular, the comparison of gene sequences in large numbers of patients and controls will be a key step in strategies for disease gene identification.

Importantly this new vaccine has a better safety profile than traditional injection allergen immunotherapy, however the trial participants experienced a high frequency of local side effects which were unexpected and warrants further investigation in larger numbers of patients.»

In a pilot study, these investigators examined the safety and feasibility of the protocol in a large number of patients from different institutions, and identified predictors of the clinical response to the treatment.

Imagine a new pill that reduced the risk of heart problems by 40 % in large numbers of patients.

In this large number of patients who attempted a gluten free diet; the majority of them had improvement or remission [11].

We expect veterinarians as well as cat and small dog owners around the country will be pleased since Comfortis, with its excellent efficacy, can now be used in a larger number of patients.»

This works well in a large number of patients but there comes a time when even with plenty of fluids, the sick kidney simply can not get the toxins out.

Not exact matches

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

This month's referral to treatment times in Wales have shown a large increase in the number of patients waiting over 9 months to start a course of treatment.

Researchers at Johns Hopkins Bayview Medical Center used two relatively simple tactics to significantly reduce the number of unnecessary blood tests to assess symptoms of heart attack and chest pain and to achieve a large decrease in patient charges.

«If we find that lymphoscintigrams using tilmanocept are at least as good as the conventional radiocolloid tracer in identification and visualization of sentinel nodes, we would like to see a randomised clinical trial involving large numbers of patients,» says Prof de Bree.

«It is particularly good news for the large number of affected patients that if they are in good medical care and have survived breast cancer, they do not need to be more worried about deadly heart diseases than women at the same age without breast cancer.»

«Even in the era of immunotherapy, there are not large numbers of metastatic NSCLC patients with durable responses to systemic therapy.

«We have shown that a large number of study participants are routinely exposed to the risks of trial participation without the benefits that sharing and publishing results would have for patients in the future.

The Thorough QT clinical assessment also has its limitations, as those studies are done in humans and typically require large numbers of patients.

The findings of a research group in Manchester, published in the Emergency Medicine Journal, could potentially make a huge difference to a large number of patients.

The large number of patient records allows for the development of reliable benchmarks for centers to reference in comparing their local results against risk - adjusted national standards.

«We look for activity of our molecules in phase 2, and on numerous occasions we generate statistically significant data with relatively small numbers of patients, which gives us reasonable confidence that the program will be successful in phase 3 with a larger group of patients.

Dr Jeremy McRae, first author from the Wellcome Trust Sanger Institute, said: «Each of these disorders is incredibly rare, so the large number of patients in this study was crucial to diagnosis.

In the event that it becomes possible to generate large numbers of specialized cells for transplantation, such a facility would aim to find reasonable tissue matches for patients so that rejection can be tackled using conventional immunosuppressives.

Many of the variants involved in numerous types of cancer have been identified with genetic sequencing studies of large numbers of patients.

The assay was implemented in five countries and tested using a large number of clinical samples from travelers and patients living in areas with a high level of exposure to Zika virus and other flaviviruses.

Researchers are planning to extend the clinical trial to a much larger number of patients in a multinational study, to demonstrate not only a reduced infarct size, but also a reduced mortality in patients who receive early metoprolol during transit to hospital.

Staffing: Large numbers of staff are needed to care for an individual patient due to the intensity of treatment, the extended need for personal protective equipment, and the necessity to limit work shifts in the patient room to 2 - 4 hours to combat physical and mental fatigue.

In an editorial accompanying the published article in Circulation, experts from the Technische Universität and the Munich Heart Alliance, Gjin Ndrepepa and Adnan Kastrati, affirmed that, if confirmed by a subsequent analysis of large numbers of patients, the results of METOCARD - CNIC trial are likely to lead to a change in clinical practice: «In this regard, a pharmaco - protective strategy able to reduce infarct size by 20 percent when used in conjunction with primary PCI nurtures great hope in clinical benefit.&raquIn an editorial accompanying the published article in Circulation, experts from the Technische Universität and the Munich Heart Alliance, Gjin Ndrepepa and Adnan Kastrati, affirmed that, if confirmed by a subsequent analysis of large numbers of patients, the results of METOCARD - CNIC trial are likely to lead to a change in clinical practice: «In this regard, a pharmaco - protective strategy able to reduce infarct size by 20 percent when used in conjunction with primary PCI nurtures great hope in clinical benefit.&raquin Circulation, experts from the Technische Universität and the Munich Heart Alliance, Gjin Ndrepepa and Adnan Kastrati, affirmed that, if confirmed by a subsequent analysis of large numbers of patients, the results of METOCARD - CNIC trial are likely to lead to a change in clinical practice: «In this regard, a pharmaco - protective strategy able to reduce infarct size by 20 percent when used in conjunction with primary PCI nurtures great hope in clinical benefit.&raquin clinical practice: «In this regard, a pharmaco - protective strategy able to reduce infarct size by 20 percent when used in conjunction with primary PCI nurtures great hope in clinical benefit.&raquIn this regard, a pharmaco - protective strategy able to reduce infarct size by 20 percent when used in conjunction with primary PCI nurtures great hope in clinical benefit.&raquin conjunction with primary PCI nurtures great hope in clinical benefit.&raquin clinical benefit.»

The research initiative will image larger numbers of patients to confirm and investigate further applications for ADC mapping in the spine.

MDR - TB has been on the increase worldwide over the past decade, with the largest number of patients living in the European WHO region.

«When we compared the gene signature activity of glioblastoma cells from around 60 patients we found that a large number of patients could be divided into subgroups that showed a correlation between gene activity, tumor cell characteristics and cell of origin similar to the one we had seen in the mouse study.

But if researchers can pin down how the mutated protein exerts its effects, they may learn just what kills off crucial neurons in the much larger number of patients with nonhereditary Parkinson's.

In future studies, Sahin and colleagues hope to generate larger numbers of patient - derived cells to investigate differences between patients with TSC alone and those who also have ASD.

Oskar Ström, RPh, PhDc, co-author of the study said: «Our model, based on Swedish costs and fracture risk data, shows that the widespread implementation of FLS has the potential to prevent a large number of fractures in Swedish patients with only a moderate cost per quality - adjusted life - year.»

St. Michael's was the only site outside of the United States involved in the Phase 2 clinical trial for the drug and had the largest number of patients enrolled in the Phase 3 trial.

While there have been attempts to estimate real - time death risks during epidemics, such statistical models require data from large numbers of patients in the order of thousands and therefore could not be applied to the 2015 MERS epidemic in the Republic of Korea with small patient numbers.

The larger number of people in the two more recent studies — as well as the use of U.S. patients in the new analyses — strengthens this earlier evidence.

The Krainer team, in collaboration with a team at Isis Pharmaceuticals, surveyed a large number of antisense oligonucleotides (ASOs) and found that some of these ASOs are able to correct the mRNA splicing defect in cultured cells from SMA patients.

«Each of these disorders is incredibly rare, so the large number of patients in this study was crucial to diagnosis.

A new study by researchers at Partners HealthCare, one of the nation's largest Medicare Accountable Care Organizations (ACOs), shows that physician turnover and low numbers of enrolled patients play a key role in an ACO's ability to meet its financial targets.

A very large number of changes have been discovered in HD model mice and then subsequently observed in human HD patients, suggesting the mice are useful research tools, even if they don't really have Huntington's disease.

«In the clinic, a large number of (Alzheimer's disease) patients have diabetes and chronic inflammatory states going on at the same time,» said Jefferson Kinney, a UNLV neuroscience researcher and professor in the psychology departmenIn the clinic, a large number of (Alzheimer's disease) patients have diabetes and chronic inflammatory states going on at the same time,» said Jefferson Kinney, a UNLV neuroscience researcher and professor in the psychology departmenin the psychology department.

In the first trial (Neurology 2007; 68:51 — 55), 12 weeks of phenylbutyrate treatment produced no beneficial effects, although the small number and relatively large age range of the patients may have hidden a modest effect.

Several research groups at Uppsala University participated in the present study, where they analysed the NF - kB genes in a large number of CLL patients.

In humans, because invasive studies are not ethically permissible except in some neurological patients, by far the largest number of EEG studies have been conducted using electrodes glued to the scalIn humans, because invasive studies are not ethically permissible except in some neurological patients, by far the largest number of EEG studies have been conducted using electrodes glued to the scalin some neurological patients, by far the largest number of EEG studies have been conducted using electrodes glued to the scalp.

The use of human embryonic stem cells, as opposed to patient blood, as the starting material for AST - VAC2 provides a scalable system for the production of a large number of vaccine doses in a single lot, reducing manufacturing costs, enabling «off - the - shelf» availability, and ensuring product consistency.

Clonal persistent patients harbored a larger number of residual tumor cells with genotypes and phenotypes that were altered in response to NAC.»

«For the information to eventually be used in the clinic, we will need to perform this type of analysis on even larger numbers of patients.»

In an attempt to bring patient - specific induced pluripotent stem cell (iPSCs) technology closer to the clinic, researchers have created iPSCs from patient - derived chondrocytes, using an non-integrative reprogramming method, and used these to then create large numbers of cartilage producing cells.

Hospitalists typically work in shifts; therefore, within the same hospital, patients treated by hospitalists are plausibly quasi-randomized to a given physician based on when patients become sick and based on hospitalists» work schedule.34 We defined hospitalists using a validated approach: general internists who filed at least 90 % of their total evaluation and management billings in an inpatient setting.35 Second, to evaluate whether our findings were sensitive to how we attributed patients to physicians, we tested the following 2 alternative attribution methods: attributing patients to physicians who had the largest number of evaluation and management claims and attributing patients to physicians who billed the first evaluation and management claim for a given hospitalization.25, 36,37 Third, within some hospitals, male internists may be more likely to work in intensive care units and have severely ill patients.

«We have a larger number of patients in our group than on any single clinical trial, so we hope this will be an opportunity for researchers to learn about us and a way for us to learn more about our condition.

In a substudy, review outcomes were also compared across different types of clinical research, based in large part on the designations and definitions derived from a number of sources, including a report by Nathan, 14 the Institute of Medicine, 20 the NIH Director's Panel on Clinical Research, 9 the Association of American Medical Colleges and American Medical Association, 21 and the Agency for Healthcare Research and Quality.22 All 3599 R01 applications involving human subjects that were submitted to NIH for the October 2002 council were categorized into 1 of the following: (1) patient - oriented studies of mechanisms of human disease (bench to bedside); (2) clinical trials and other clinical interventions; (3) patient - oriented research focusing on development of new technologies; (4) epidemiological studies; (5) behavioral studies (including studies of normal human behavior); (6) health services research; and (7) use of deidentified human tissuIn a substudy, review outcomes were also compared across different types of clinical research, based in large part on the designations and definitions derived from a number of sources, including a report by Nathan, 14 the Institute of Medicine, 20 the NIH Director's Panel on Clinical Research, 9 the Association of American Medical Colleges and American Medical Association, 21 and the Agency for Healthcare Research and Quality.22 All 3599 R01 applications involving human subjects that were submitted to NIH for the October 2002 council were categorized into 1 of the following: (1) patient - oriented studies of mechanisms of human disease (bench to bedside); (2) clinical trials and other clinical interventions; (3) patient - oriented research focusing on development of new technologies; (4) epidemiological studies; (5) behavioral studies (including studies of normal human behavior); (6) health services research; and (7) use of deidentified human tissuin large part on the designations and definitions derived from a number of sources, including a report by Nathan, 14 the Institute of Medicine, 20 the NIH Director's Panel on Clinical Research, 9 the Association of American Medical Colleges and American Medical Association, 21 and the Agency for Healthcare Research and Quality.22 All 3599 R01 applications involving human subjects that were submitted to NIH for the October 2002 council were categorized into 1 of the following: (1) patient - oriented studies of mechanisms of human disease (bench to bedside); (2) clinical trials and other clinical interventions; (3) patient - oriented research focusing on development of new technologies; (4) epidemiological studies; (5) behavioral studies (including studies of normal human behavior); (6) health services research; and (7) use of deidentified human tissue.