Sentences with phrase «in larger phase»

The researchers noted that initial clinical trial data have been validated in larger phase II trials in the setting of relapsed / refractory HL, non-Hodgkin's lymphoma (NHL), and multiple myeloma (MM).

A test - of - concept trial is not designed to establish the efficacy of a particular candidate but rather to help researchers decide if a candidate is worth testing in larger Phase III trials.

Should the results of this study be repeated in the larger Phase III trial, it would lead to a new standard of care for kidney cancer patients, said Dr. Hammers, formerly of Johns Hopkins medical system, who holds the Eugene P. Frenkel, M.D. Scholar in Clinical Medicine at UT Southwestern.

However, our promising results warrant further investigation in larger phase 3 disability - driven trials.»

They estimate that using these algorithms to predict outcomes could allow a drug sponsor to reduce the size of the trial by at least 20 % and save as much as $ 6 million in a large phase III trial.

Plans are underway at the MHRP site in Nigeria to participate in a large phase 2 study of the ChAd3 Ebola vaccine.

Merck's anti-PD-1 drug pembrolizumab (MK - 3475) is currently being investigated in a large a phase I trial for patients with metastatic melanoma and lung cancer.

Not exact matches

The partners are joint investors in the $ 100 billion Vision Fund, the world's largest private equity fund, which will provide the initial cash for the first phase of the scheme.

The $ 560 - million investment — the largest in the Canadian food industry — is the third and final phase of a sweeping $ 1.3 - billion restructuring strategy the company launched in 2006, which has since reached every corner of operations, from hog rendering to baked goods and now, finally, prepared meats.

Enrolment in the plan would take place in stages, beginning with the largest employers, while contribution rates would be phased in over two years.

So as she prepared to open a larger space this February, she decided to phase out tips completely, in favor of a flat wage for her servers and a higher minimum wage for her other workers.

There is a large amount of literature that shows this second phase is helpful in attaining goals.

Rieder notes they're now the largest cohort in history and are entering a phase in which they will be the biggest - spending segment of the economy.

«We phased out the charge last year,» an Indigo rep told me via e-mail, adding «a large factor in our decision was customer feedback.»

The second phase of the research, later this year, will consist of a wider survey of around 300 consumers in order to refine the hypotheses, and the final round will be a general survey on a larger scale to validate the findings.

The first phase of the 2nd Avenue line is currently set to open in December, and will feature 12 large tile mosaic portraits by Chuck Close at its 86th Street station.

In the initial bootstrap phase of the business, you would have to pick a niche, focus on the builder (as opposed to the more general purpose scheme), go out and sell, sell, sell to your niche, and get enough revenue to work on the larger idea.

LONDON Royal Dutch Shell said on Thursday it would write down its reserves in the Groningen gas field, one of Europe's largest, following the Dutch government's decision to phase out production by 2030.

LONDON, April 26 Royal Dutch Shell said on Thursday it would write down its reserves in the Groningen gas field, one of Europe's largest, following the Dutch government's decision to phase out production by 2030.

Marriott's Ko Olina Beach Club, located on a secluded lagoon within the upscale Ko Olina Resort, recently completed its fifth development phase, delivering 132 new two - and three - bedroom villas to Marriott Vacation Club's largest resort in the Hawaiian Islands.

The results, which mirror those of similar, small - scale studies of the illegal drug in recent years, come as MDMA is about to enter larger, Phase 3 trials this summer.

«We expect this to be the first phase of a much larger initiative that will provide our network with the opportunity to gain perspective into emerging technologies and will also provide access to best - in - class Canadian entrepreneurs.»

Our research, and years of investment and operating experience in Canada, highlights a persistent imbalance between the large number of technology companies seeking emerging - growth financing and the amount of capital targeting companies in their initial growth phase.

One of Juno's rivals, Kite Pharma, yesterday said it had completed its enrollment of 72 patients with diffuse large B - cell lymphoma in the Phase II portion of the ZUMA - 1 trial, designed to assess KTE - C19.

Dr. Newman added that rival CAR T cell therapy developer Kite Pharma was still likelier to generate more revenue than Juno with KTE - C19, which last week completed patient enrollment in the Phase II portion of the ZUMA - 1 trial in patients with diffuse large B - cell lymphoma.

He has worked his way up from operational roles in the base and precious metals arenas to executive positions in some of the largest mining companies in the world and has successfully managed eight mining projects through feasibility study, development and construction phases.

Even during the severe 2007 — 2009 bear market Hasbro managed to deliver large gains in the seasonally strong phase.

The plumbing and mechanics of the synthetic gold market, in our opinion, are symptomatic of a more generalized preoccupation in the financial markets at large for risk mitigation, and a quest for greater leverage during a market phase where returns have been compressed by an excess of capital.

Meanwhile, personal and dependent exemptions are eliminated in favor of a larger standard deduction and child tax credit, both of which phase out for the highest earners.

Today, we're a Fortune 500 company that connects the largest community of participants in all major markets at key phases of the investing, trading, hedging and capital raising lifecycle.

It is also the largest global player in the bream and bass category with vertically integrated operations that can effectively execute all phases of fish farming including incubation, harvesting, processing, and fish - feed production.

«The next steps in DPX - RSV will be expensive steps (large RSV infection avoidance studies, or perhaps even challenge studies, will need to be conducted in Phase 3), and so we agree with management's strategy to identify cash - contributing partners before investing its own capital in new DPX - RSV clinical initiatives,» he added.

In part, this will come from the consolidation of the tech sector and expansion of small firms still in a high - growth phase, comprising a large share of current serviced office userIn part, this will come from the consolidation of the tech sector and expansion of small firms still in a high - growth phase, comprising a large share of current serviced office userin a high - growth phase, comprising a large share of current serviced office users.

The combined business will own a betting shop network spanning Victoria, NSW, Queensland, South Australia, Tasmania and the Northern Territory and an online wagering business across the TAB, UBet and Luxbet brands that would be the largest in the country as measured by turnover — though the UBet brand will be phased out and replaced by the TAB brand across retail outlets.

The basis of a marketplace lies in having a large user base, thus, growth is absolutely crucial at the launch phase, making a growth hacker a very useful person to have.

Entrepreneurs who are on their way with their businesses, and are looking to succeed in the next phase of development of their endeavor often ask me: «What is the key to turn a small startup into a large - scale business?

Her latest novel, The Handmaid's Tale (Houghton Mifflin, 1986), is commanding attention as a considerably more ambitious book, part of a new phase of her work that includes the poems in True Stories and the novel Bodily Harm (both published in 1981) Exposing male / female power games within an alarmingly widened field of vision, Atwood bears prophetic witness to the largest, most subtle and most violent manifestations of power in our time.

Members of a church may identify the focus of their common hope with the phenomenon of warmth20 and point to specific occurrences of warmth in places or phases of congregational life.21 Members of Corinth Methodist experienced warmth at various physical and temporal thresholds that bound its life to its larger neighborhood.

One, he might claim that all actual entities are in phase and the largest temporal extensions are multiples of the smallest extension, e.g., 1/320, 1/160, 3/320, 1/80, 1/64 Here it would suffice to have the temporal extension of the divine experience as that of the shortest temporal extension.

In all these cases, up to but excluding Man, the arrangement seems to have been brought about mainly by the working of chance and of probing; but phases a to c the majority of the groups (except in the case of very large molecules) represent knots of stability, whereas in phase d the arrangements that survive represent privileged centers of activityIn all these cases, up to but excluding Man, the arrangement seems to have been brought about mainly by the working of chance and of probing; but phases a to c the majority of the groups (except in the case of very large molecules) represent knots of stability, whereas in phase d the arrangements that survive represent privileged centers of activityin the case of very large molecules) represent knots of stability, whereas in phase d the arrangements that survive represent privileged centers of activityin phase d the arrangements that survive represent privileged centers of activity.)

Though the pattern varied, most of our large cities, especially in the north, developed councils of churches as instruments of cooperative ministry, and these were ready for use when the final phases of the urbanization of America began.

Petty apartheid, the public facilities Jim Crow practices that are truly being phased out in the larger cities (where they matter), are trivial and largely irrelevant to the grander strategies of both apartheid and liberation: A point sometimes lost on American liberals who remember the U.S. civil rights activism of the sixties.

The forces holding diiodine molecules in the crystal are modest, and liquid iodine is not stable at ordinary temperatures and pressures, so that solid iodine sublimes to give a rather large concentration of diatomic molecules in the vapor phase.

While Costco and Meijer scored the lowest and Delhaize America scored the highest, none of the stores received a passing grade, despite the majority of the retailers being members of the Consumer Goods Forum (CGF), an international network of the world's largest retailers, which in 2010 committed to begin phasing out HFCs in 2015.

Sonic Corp. (NASDAQ: SONC), the nation's largest chain of drive - in restaurants, announced plans to phase in a pork supply chain free of gestation crates.

I believe, a good exercise would be to take a sufficiently large sample size of players who played for Arsenal and some other club for a long period, say at least 3 - 4 years and compare their injury records in the two phases (number, frequency and nature of injuries incurred).

In Phase One, we investigated sixteen large - scale repeated cross-sectional

In Phase One, we investigated sixteen large - scale repeated cross-sectional and longitudinal UK research datasets to discover how they collect information on British fathers; and how they identify and differentiate different types of fathers and father - figures.

Sometimes I do crave and wish for an outlet to share myself andserve in these particular ways that I love... But I know that this phase of my little ones being little is so very short in the large scheme of things and there will be plenty of time for my career later on when I'm ready.

One of the largest single developments in the history of Arlington Heights got the final green light from the Village Board, with the developer hoping the first phase will be open by next summer.