Sentences with phrase «in larger trials»

In addition, replication of positive results in larger trials is costly, and NIMH is constrained by limited funding and a budget that has lagged well behind inflation over the last decade.

Additional limitations to the traditional approach include: costly failures to replicate positive results in larger trials; difficulty in determining the reasons for negative results; low yield in terms of identifying disease or intervention mechanisms due to an exclusive focus on symptom change and clinical endpoints; and, the expensive and very lengthy practice of first establishing multi-component psychosocial treatments followed by years of «unpacking» studies.

In any case, while the results need replication in larger trials, they point to a potential method to target drug therapy for PTSD patients.

The small, phase 1 trial enrolled 11 patients and found that side - effects were similar in this population as previously reported in larger trials of enzalutamide against prostate cancer.

The company then analyzes the different varieties, and the varieties that are successful will be planted in a larger trial consisting of several acres, and tested in different growing areas.

In March, in their largest trial so far, they used a plastic tube 14 centimetres wide which reached from the surface of Lake Nyos to its bed, 208 metres below.

Research fingering glutamate signaling in negative symptoms has spurred the idea of targeting glutamate receptors, but this approach has failed in large trials.

If these results are confirmed in a larger trial, they will help to change how diabetic eye disease is evaluated and treated, says Paolo Silva, M.D., staff ophthalmologist and assistant chief of telemedicine at Joslin's Beetham Eye Institute.

However, The independent evaluators from National Centre for Social Research found that the children who received the Switch - on intervention in this larger trial made no more progress than the children in the «business as usual» control group.

Not exact matches

While the new mid-stage study results from DNDi were impressive (they showed cure rates of 96 % to 97 % even for the sickest patients and those with liver scarring), more late - stage trials will be necessary before the drug is available on a large scale in the developing world.

While there were dissenters, the Supreme Court found that Skilling's negative publicity didn't prevent him from receiving a fair trial — especially because Houston was the fourth - most - populous city in the country, allowing for a large jury pool.

Just this month, as part of the first large - scale clinical trial of its kind, researchers working in rural India found that newborns who were given a synbiotic were at a substantially lower risk of developing sepsis, a potentially fatal condition characterized by severe infection.

Currently in the U.K., he will go back to Privateer's headquarters in Seattle, then visit Tilray's 60,000 - square foot facilities in British Columbia, Canada, then to Australia, where Tilray has an import license to send marijuana for a clinical trial with a chemotherapy - induced nausea and vomiting study with the University of Sydney, the government of New South Wales and the country's largest cancer hospital.

The 5G plan announced on Tuesday by the third - largest wireless carrier stands in start contrast to the emphasis from bigger competitors Verizon (vz) and AT&T, which are both running trials for fixed wireless Internet service using 5G to serve homes and businesses.

Residents at Alkimos Beach and White Gum Valley are set to participate in trials of solar energy technology and battery storage that could lead to large reductions in power bills.

Years of trial and error have taught me that I prefer to eat much larger infrequent meals and not to start eating until later on in the day.

The program will involve clinical trials testing for safety in humans, followed by a larger trial using non-human primates exposed to Ebola.

In a surprising twist, Merck's anacetrapib, a heart disease drug, produced strong results in a large clinical trial of 30,000 patients, according to the companIn a surprising twist, Merck's anacetrapib, a heart disease drug, produced strong results in a large clinical trial of 30,000 patients, according to the companin a large clinical trial of 30,000 patients, according to the company.

Following preliminary clinical trials, the company is now in discussion with a major New York City hospital to integrate Fever Smart into a large clinical research program.

GUMC says its researchers are now planning larger clinical trials with nilotinib for patients with Parkinson's and other similar diseases including Alzheimer's disease, likely to begin in 2016.

David Sanford, chairman of Sanford Heisler Sharp, the law firm that argued the largest - ever employment gender discrimination case to go to trial — a class action suit against Novartis Pharmaceuticals that resulted in a $ 253 million jury award for plaintiffs in 2010, reduced post-trial to $ 175 million — noted that in that case, the company had just three investigators for a workforce of thousands.

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

Announced a clinical trial collaboration with Pfizer, Inc. (Pfizer) to evaluate the safety and efficacy of the investigational combination of Yescarta and Pfizer's utomilumab, a fully humanized 4 - 1BB agonist monoclonal antibody, in patients with refractory large B - cell lymphoma.

We talk with two pioneering physicians — one of whom is overseeing the world's largest HIV vaccine trial and the other led a groundbreaking successful pilot in the U.S. — to see how far we are from getting to zero.

Grail, a year - old, Menlo Park, Ca. - based early cancer screening startup that spun out of the DNA - sequencing giant Illumina is reportedly looking to raise up to $ 1.7 billion in fresh funding to launch a large - scale clinical trial.

The results, which mirror those of similar, small - scale studies of the illegal drug in recent years, come as MDMA is about to enter larger, Phase 3 trials this summer.

Trial lawyers like Schlichter are winning 401k fee lawsuits and cashing in with large settlements.

However, there is a need for larger randomized control trials to explain these benefits in a larger level.»

The adaptive pathways concept applies primarily to treatments in areas of high medical need where it is difficult to collect data via traditional routes and where large clinical trials would unnecessarily expose patients who are unlikely to benefit from the medicine.

One of Juno's rivals, Kite Pharma, yesterday said it had completed its enrollment of 72 patients with diffuse large B - cell lymphoma in the Phase II portion of the ZUMA - 1 trial, designed to assess KTE - C19.

Dr. Newman added that rival CAR T cell therapy developer Kite Pharma was still likelier to generate more revenue than Juno with KTE - C19, which last week completed patient enrollment in the Phase II portion of the ZUMA - 1 trial in patients with diffuse large B - cell lymphoma.

Denton said that he estimates there's a roughly 1 - in - 10 chance that Gawker will face «disaster» — meaning that they lose the trial, the jury awards Hogan a large amount in damages, and Gawker is required to put up a bond for the full amount while it appeals the ruling.

A large well completion trial in its Catarina assets didn't produce the results the company had hoped.

It is currently doing a much larger confirmatory trial in Hodgkin's lymphoma.

Prophecy Resource (TSX.V: PCY) has begun production of its first 10,000 tonnes of coal as a trial run of supply to be taken by rail to electric power stations in Darkhan and Erdenet, Mongolia's second and third largest cities after the capital, Ulaanbaatar.

The second reason is that Amarin will finally announce the top - line results of its large cardiovascular outcomes trial for Vascepa sometime in the third quarter of 2018.

Although Lu - PSMA - 617 put up good numbers in its small single - arm study, it still needs to outperform a physician's choice of approved treatments in a much larger global trial.

If myelofibrosis trial results are consistent with previous observations, the healthcare behemoth will help fund larger trials in order to support New Drug Applications.

Recent sex discrimination cases resulting in large settlements, in some cases awards of multi-million dollars, to be split with aggressive trial attorneys, are the latest examples of misusing the Civil Rights Act of 1964.

«The two largest groups containing prisoners in the camps, both numbering in the millions, were the Polish Jews and the Soviet prisoners of war (POWs) held without trial or judicial process.

Biblical inerrancy is debated in America's largest denomination with the same vigor, and in almost the precise terms, that it was in the 1890s Charles Briggs trial.

In an early trial of this recipe I didn't have chocolate chips on hand so I did this as a backup plan, but I ended up really liking the texture the larger chunks of chocolate added so I kept using this method.

I came upon my ratios thru trial and error and made alot of choco sauce in the process but came upon that ratio that works, and it's interesting, yours is the same, just larger quantity.

Melt butter in large skillet on medium - high heat (or in small skillet for trial recipe).

He contributes to other large - scale clinical trials including SAVE (evaluating whether treatment of obstructive sleep apnoea with continuous positive airways pressure can reduce the incidence of serious CV events in patients with established CVD), and CREDENCE, a randomised, double - blind, placebo - controlled trial assessing whether canagliflozin can slow the progression of diabetic nephropathy in patients with type 2 diabetes.

It's also a game that became dangerous for me when it introduced online rankings, as I could not stop playing once I noticed where I ranked in North America on time trial courses from the Wii edition — it was that experience with the time trials mode from my youth all over again, except instead of just besting myself and my dad and a couple of friends, it was a large percentage of a continent that I'm embarrassed to even quote here as it will give away just how time I spent with the game.

Three years of brilliant performances make Jones the 100 - and 200 - meter favorite at the trials, especially with Miller — who has not looked sharp in recent European races — saying last week that she is running merely to make the team in Sacramento, with victory in Sydney as her larger goal.

The Walk to Freedom of 1963 was the nation's largest civil rights demonstration in history at that time — a trial run for the March on Washington — and it stopped at Cobo.

Hoeness, the larger - than - life club president, goes on trial in 2014 for tax evasion and the media is currently awash with stories of the «Bayern mole» — the insider who leaked Guardiola's line - up and tactical plans to Bild newspaper on the eve of November's top - of - the - table trip to Dortmund.

One large trial in patients with heart disease showe d that supplementing with 1 gram of omega - 3 per day reduced their risk of death by 20 %.