Sentences with phrase «in lean mice»

While IRAB - A produced a decrease in blood glucose in lean mice, the data in DIO mice indicated an exacerbation of insulin resistance; these data were unexpected and suggested the interplay of complex unknown pharmacology.

We estimate that the percentage of macrophages in adipose tissue ranges from under 10 % in lean mice and humans to over 50 % in extremely obese, leptin - deficient mice and nearly 40 % in obese humans.

To explore that question, a team led by Cornell University biomedical engineer Claudia Fischbach first showed that female mice that were obese, because of genetics or a high - fat diet, had more fibrous mammary fat pads with straighter collagen fibers than those seen in lean mice (see image).

Not exact matches

To find out what was going on in the microbiomes of four sets of differently shaped identical twins, researchers transferred some gut bacteria from a lean (human) twin to a sterile mouse: one with no foreign bacteria at all.

«How obesity dulls the sense of taste: Obese mice had about 25 percent fewer taste buds than lean mice in study.»

Scientists reached this conclusion by transferring microbes from bypass - treated obese mice to a group of lean mice raised in sterile conditions that left them with no intestinal bacteria at all.

As such, the altered metabolism in the bone cells caused the mice to have a beneficial whole - body glucose turnover and a lean body.

In another animal microbiome experiment, Jeffrey Gordon, a biologist at Washington University in St. Louis, took a suite of microbes from the guts of both obese and lean mice and transplanted them into the guts of microbe - free micIn another animal microbiome experiment, Jeffrey Gordon, a biologist at Washington University in St. Louis, took a suite of microbes from the guts of both obese and lean mice and transplanted them into the guts of microbe - free micin St. Louis, took a suite of microbes from the guts of both obese and lean mice and transplanted them into the guts of microbe - free mice.

Validating their theory, the research team discovered that SR8278 increased lean mass and muscle function and decreased muscle fibrosis and muscle protein degradation in mice.

In the mice that consumed either type of tea extract, there was less of the type of bacteria associated with obesity and more of the bacteria associated with lean body mass.

She leaned her curly head over his car seat, tickled his toes and cooed like a pro — in a voice squeakier than Mickey Mouse's.

«The nondigestible compounds in the Granny Smith apples actually changed the proportions of fecal bacteria from obese mice to be similar to that of lean mice,» Noratto said.

In this study, he exposed lean, brown - furred female mice to 50 milligrams of BPA per kilogram of body weight daily, and the next generation was transformed: More of them were fat, with blond fur.

«Importantly, we found that blocking the actions of the endocannabinoids with pharmacological inhibitors of cannabinoid receptors in the periphery completely normalized food intake and meal patterns in western diet - induced obese mice to levels found in control lean mice fed standard chow.»

In addition, lean mice who received vaccines with adjuvants were protected from severe flu infections.

The obese mice seemed more susceptible to the virus, which remained elevated following vaccination compared to blood levels in lean animals.

Researchers looked at the immune response to vaccination in lean and obese mice, including how vaccine dose and different adjuvants impacted that response.

While adjuvants improved the immune response to vaccinations in both lean and obese mice, the overall immune response was reduced in the obese animals compared to their lean counterparts.

Next, they reduced the blood aP2 levels in obese and diabetic mice to low levels seen in lean healthy mice.

Cohousing mice harboring an obese twin's microbiota (Ob) with mice containing the lean co-twin's microbiota (Ln) prevented the development of increased body mass and obesity - associated metabolic phenotypes in Ob cage mates.

In an attempt to increase sensitivity for sepsis, Canaan aged these FAT10 knockout mice and made the discovery that mice lacking the gene were lean and aged more slowly.

By comparing the behavior of XBP - 1s in the obese mice with that in lean, healthy ones, he discovered an inflammatory protein that modifies XBP - 1s in healthy animals so it can be shuttled into the nucleus.

Associate Professor Amanda Sainsbury - Salis expressed surprise at the impact of the Y6 gene deletion on mice, commenting «I find it amazing that one gene, which is expressed in the small part of the brain that controls the body clock, has such a profound impact on how much fat is stored on the body, and how much lean tissue is maintained.»

But the babies of adiponectin - treated mice were about the same weight as those born to lean control mice, the researchers report online today in the Proceedings of the National Academy of Sciences.

Now Catherine Suter at Victor Chang Cardiac Research Institute in Sydney and her colleagues have investigated the longer - term effects of paternal obesity by mating obese male mice with lean females.

The mice who got microbes from the lean twins stayed lean, the researchers report today in Science.

Correlation of gene expression occurred across lean and obese mice, defining a common transcriptional response to variations in adiposity.

Lean muscle mass was 18.2 % less in IL - 15Rα — KO mice compared with B6129 mice (Figure 4B).

Our results indicate that the percentage of macrophages in the adipose tissue that surrounds and infiltrates the extensor digitalis longus muscle is increased in obese mice compared with lean mice.

Adipose tissue within muscle contained significant numbers of F4 / 80 + macrophages, and the percentage of F4 / 80 + cells within this adipose tissue was markedly increased in obese mice compared with lean mice (41 % ± 4 % of macrophages vs. 12 % ± 2 % of macrophages, respectively; P < 0.005, mean ± SD)(Figure 4).

(B) Lean muscle mass, assessed using NMR, was 18 % less in IL - 15Rα — KO mice (n = 8) compared with B6129 control mice (n = 8).

Macrophages in the liver and muscle of lean and obese mice.

Immunohistochemical detection of cells expressing the macrophage - specific antigen F4 / 80 (arrows) in extensor digitalis longus muscles from C57BL / 6J (a and c) Lepob / ob female and (b and d) lean female mice.

Macrophages in the adipose tissue of lean mice were uniformly small, isolated, and widely dispersed among the adipocytes.

This difference may be explained by the reduced levels of normal CST in obese mice compared to the lean control animals.

We calculated the average adipocyte cross-sectional area and the percentage of F4 / 80 - expressing cells in the perigonadal, perirenal, mesenteric, and subcutaneous inguinal adipose tissue depots from Ay / + female, Lepob / ob female, lean male, and diet - induced obese (DIO) male mice.

Results showing C. minuta has an effect of controlling fat gain in the mouse match data that reveal lean people have a greater abundance of C. minuta in their gut than obese people.

The percentage of F4 / 80 - positive macrophages within this adipose tissue was markedly increased in obese compared with lean mice (e, P < 0.005).

P65 inactivation in adipocytes and macrophages attenuates adipose inflammatory response in lean but not in obese mice.

The scientists found that obese mice had more harmful bacteria in their guts compared to lean mice, which caused inflammation throughout their bodies, leading to very rapid joint deterioration.

The classic lab mouse is black or white, eats a precisely measured diet to keep him lean, and is relatively young — probably a teenager or young adult in rodent years.

Maternal Obesity in Pregnancy Developmentally Programs Adipose Tissue Inflammation in Young, Lean Male Mice Offspring.

In 2005, together with Washington University microbiologist Jeffrey Gordon and others, Knight used the tools to catalog the microbes that inhabit the intestines of lean and obese mice, in hopes of uncovering relationships between microbes and metabolic healtIn 2005, together with Washington University microbiologist Jeffrey Gordon and others, Knight used the tools to catalog the microbes that inhabit the intestines of lean and obese mice, in hopes of uncovering relationships between microbes and metabolic healtin hopes of uncovering relationships between microbes and metabolic health.

Treated mice become lean, and develop larger muscles and endurance, suggesting a multitude of therapeutic uses in people.

The hepatic expression level is up - regulated in obese mice compared to lean animals (PubMed: 21987372).

Lean and diet - induced obese mice were used to characterize single - dose in vivo pharmacological effects of IRAB - A; multiple - dose IRAB - A effects were tested in obese mice.

After exercising for six weeks, both obese and lean mice showed a significant reduction in the overall size of fat cells and the overall amount fat in the marrow.

According to a study led by Italian researchers, using lean and overweight mice which were given melatonin in their drinking water, melatonin reduces weight.

In one study, researchers took microbiome samples from both lean and obese mice and placed them in the gut of neutral micIn one study, researchers took microbiome samples from both lean and obese mice and placed them in the gut of neutral micin the gut of neutral mice.

In the overweight mice, there was a significant weight lose after eight weeks, but the case was not the same with the lean mice.