Sentences with phrase «in leukemic»

In leukemic cells, like in other cancers, STAT proteins are frequently constitutively activated in the absence of cytokine stimulation, providing malignant cells with persistent signals and self - sufficiency for survival and proliferation.1

They were also enriched for genes expressed in leukemic stem cells of poor - prognosis AML.

Epigenetic analysis determined that the enhancer driving MYC expression in the leukemic cells was not Notch - dependent, but rather BRD4 - dependent, suggesting another possible therapeutic option for MYC - expressing tumors.

An abnormal gene created by the fusion of ETV6 and the RUNX1 gene is one of the most common alterations in childhood ALL and is found in the leukemic cells of 20 to 25 percent of pediatric ALL.

As part of the new study, researchers deleted CXCL12 production specifically from bone marrow vasculature in leukemic mice.

To block the FA repair pathway in leukemic cells, researchers tested the inhibition of a protein called mTOR (mammalian target of rapamycin).

«Two - pronged approach successfully targets DNA synthesis in leukemic cells.»

Not exact matches

Furthermore, the leukemic cells can spread to the bones and joints, which may cause pain in those areas.

I spent the next decade completing rigorous basic science research training: completing a high school summer internship, attending the University of Maryland, Baltimore County as a Meyerhoff Scholar, and completing my Ph.D. in the Stanford immunology program, where my work focused on the mechanisms regulating hematopoietic and leukemic stem cells.

The two - part approach netted a set of mutations seen only at relapse that enabled the team to sift and sort leukemic and normal stem cells using tools developed in the Dick lab a few years ago to zero in on specific cell types fated to relapse.

«Interestingly, we also found that vitamin C treatment had an effect on leukemic stem cells that resembled damage to their DNA,» says first study author Luisa Cimmino, PhD, an assistant professor in the Department of Pathology at NYU Langone Health.

The results also suggest that vitamin C might drive leukemic stem cells without TET2 mutations toward death, says Cimmino, given that it turns up any TET2 activity normally in place.

A biopsy determined the cancer was not sarcoma — a cancer of certain connective tissues — but a leukemic tumor somehow trapped in the child's cheek.

Regarding the occurrence of leukemia (leukemic transformation), a typical late complication, there were no differences between the two treatment groups in the study.

A drug commonly used to moderate diabetes that induces fat cell production in the bone marrow was used and was found to help foster red blood cell production as well as suppress leukemic disease.

This autocrine loop allows the leukemic cells to sidestep therapeutic inhibition of MET, shows a report published online in this week's Nature Medicine.

By identifying haplotypes from single - molecule reads, the authors were able to construct phylogenetic trees of the leukemic cells in a single patient, something that could only be done on the 454 platform.

Fortunately, Deshpande is an expert in studying leukemic gene regulation.

These observations, along with the characteristic morphology and immunologic findings in the present case, indicated that the disease was consistent with the features of leukemic BPDCN.

«Thanks to improvements in the understanding of AML biology, a multiplicity of so - called targeted therapies and therapies based on differential pathophysiology of leukemic stem cells compared with normal counterparts have emerged,» noted Richard M. Stone, MD, clinical director of the Adult Leukemia Program at Dana - Farber Cancer Institute in Boston, and colleagues, writing in a review for the ASCO 2017 Educational Book.

«In our research project on pediatric leukemia we plan to use Gemcode to define the exact chromosomal breakpoints of large scale chromosomal rearrangements and repetitive sequences that are typical for leukemic cells, but are difficult to characterize in short sequence reads,» said Professor Ann - Christine Syvänen, who leads the Molecular Medicine grouIn our research project on pediatric leukemia we plan to use Gemcode to define the exact chromosomal breakpoints of large scale chromosomal rearrangements and repetitive sequences that are typical for leukemic cells, but are difficult to characterize in short sequence reads,» said Professor Ann - Christine Syvänen, who leads the Molecular Medicine grouin short sequence reads,» said Professor Ann - Christine Syvänen, who leads the Molecular Medicine group.

AFM study shows prominent physical changes in elasticity and pericellular layer in human acute leukemic cells due to inadequate cell - cell communication This article appears in the collection Nanotechnology Focus on Scanning Probe Microscopy Presenter: Igor Sokolov

CD45 colocalized with lipid rafts on AML cells, which contributes to elevated GM - CSF signal intensity involved in proliferation of leukemic cells.

One of the main objectives is to investigate genome - wide changes in the epigenetic landscape of leukemic cells.

Residual leukemic cells that remain in the bone marrow following treatment are a major cause of disease relapse and can also act as an early indicator to the effectiveness of a given treatment strategy.

Work in cell lines found evidence leukemic cells require LMO1 for survival, which suggests it might be a viable therapeutic target.

The CIRM board also announced the approval of US $ 58.8 million in funding for five new clinical trials which will study potential treatments for a variety of diseases and conditions, namely malignant glioma, acute myeloid leukemic, neutropenia, high - risk type 1 diabetes and kidney disease.

In sub-group analyses, the authors noted that coffee drinking was associated with a reduced risk of bladder, breast, buccal and pharyngeal, colorectal, endometrial, esophageal, hepatocellular, leukemic, pancreatic, and prostate cancers.

When the function of XBP - 1 is genetically deleted in TCL1 mice, significantly slower leukemic progression is observed.

The lab further developed inhibitors to target the expression of XBP - 1 and established that blocking the expression of XBP - 1 by specific small - molecule chemical inhibitors can stall malignant progression of leukemia in mice and induce apoptosis in primary human leukemic cells.

Intriguingly, the somatic variants were detected in the germline sample as well at frequencies of 5 - 13 %, suggesting that the skin sample was contaminated by a small fraction of leukemic cells.

Many clinical studies have found that FLT3 ITD mutations are associated with higher concentrations of leukemic cells in both blood and bone marrow, increased incidence of relapse and decreased overall survival.

Myelosuppression is a well - established side effect of current AML therapies, with prolonged events leading to an increased risk of infections and death.44 Consequently, therapies that preferentially kill leukemic cells over normal bone marrow cells are urgently required, and the overexpression of CD123 on AML leukemic stem cells and blasts compared with normal hematopoietic cells contributes to its attractiveness as a therapeutic target in this disease.6, 45 However, severe myelosuppression and myeloablation have emerged for some investigational CD123 - targeted treatment modalities.

However, other studies in mice with breast cancer show that once cancer has already been initiated, stress can lead to increased rates of tumor spread and metastases.26 Similarly, when mice were injected with leukemic cells and stressed physically and physiologically with injections of adrenaline, cancer progression occurred.27 Some scientists even propose that, while necessary in many cases of cancer, undergoing surgery may cause enough stress to lead to tumor promotion and progression.28 Therefore, it seems like acute stress may help fight cancer, chronic stress may help cause it, but once cancer is present, both acute and chronic stress may lead to cancer progression.

Our models show that the lack of autophagy, particularly in white blood cells, leads to an accumulation of toxic waste, which then leads to DNA mutation transforming these white blood cells, for example into a leukemic cells.»

In addition, leukemic and visceral forms can occur.

Tumor necrosis factor - alpha inhibits hTERT gene expression in human myeloid normal and leukemic cells