Sentences with phrase «in living animal»

There are enzymes in every living animal and plant cell.

For 50 years of brilliant creativity in biomedical science — exemplified by his legendary work on the genetic code; his daring introduction of the roundworm Caenorhabditis elegans as a system for tracing the birth and death of every cell in a living animal; his rational voice in the debate on recombinant DNA; and his trenchant wit.

But surprisingly, Pierce said, examination of two major bones in the leg, the tibia and femur, in a living animal showed the receptor deficient mice actually had more marrow fat and lower bone mass.

«What's missing when we put the cells in culture and compared to what's happening in the bone marrow environment in a living animal?

The same molecule has been reported previously, but this is the first time it has been shown to treat dementia - like symptoms in a living animal.

By imaging cancer cells in vivo, we are studying how cells migrate in and interact with complex environments in the living animal (Fig 2C).

In the worm, we are developing tools to monitor neuromodulation at cellular resolution in an intact brain and using them to directly measure endogenous peptide release and binding to receptors on identified neurons using real - time approaches for imaging neuropeptide signaling, in order to understand the dynamics of this process in a living animal.

Imaging has advanced rapidly, he explains, to the point where scientists can watch neural connections change in vivo — that is, in the living animal — rather than having to rely on in vitro tissue samples.

Over the last couple of years our field has made such fundamental progress that we are now able to really look into the brain and see how it works, in the living animal.

All of this can be done in the living animal, and that's a huge step forward compared to what was possible only a couple of years ago.

It enables us, in a living animal, to make all nerve cells, or a subset of them — for example only the inhibitory or only the excitatory cells — visible through fluorescence.

Kissler and his research team are using a mouse model of type 1 diabetes to see what the genes do in a living animal.

«Our earlier work was the first to clearly show in vivo (in a living animal) that mature astrocytes can be reprogrammed to become functional neurons without the need of cell transplantation.

Their recipe: Let the transformation happen in a living animal instead of a petri dish.

To find out whether the virus could help treat cancer in a living animal, the researchers injected either Zika virus or saltwater (a placebo) directly into the brain tumors of 18 and 15 mice, respectively.

Adult stem cells have the ability to transform into many types of cells, but tracing the path individual stem cells follow as they mature and identifying the molecules that trigger these fateful decisions are difficult in a living animal.

«They can see a measurable result in a living animal,» says Claude Meares, a chemist at the University of California, Davis.

The faster speed means it will be possible for the first time to watch disease progression in living animal models at the molecular level.

The piriform cortex, meanwhile, is deep - seated in the brain of rodents, which made it impossible to obtain any functional images in a living animal until now.

As the cells mature, they must also be stimulated to move as they would be by bone growth and body movement in a living animal.

This is the first time that imaging with such a thin endoscope has been demonstrated in a living animal.

For the first time ever, Deisseroth's team had used optogenetics to control behavior in a living animal.

Only then was Deisseroth ready to test optogenetics in a living animal.

But its importance in the more immediate regulation of sleep, like when a bright light wakes someone up, remained debatable because the experiments needed to show its role in a living animal were essentially impossible.

In March chemists created a promising alternative: a synthetic antibody that can disable a pathogen in a living animal.

This makes it possible to examine the processes which take place during the development of epilepsy in a living animal.

Friedrich said the powerful antibiotics in live animals should turn people toward clean meat.

All these different fully functional stages at different levels of complexity are found in living animals today.

It is currently playing out in the live animal export sector, where the demise of local processing opened the door for a live export sector, which in turn through its simple business model has compromised livestock welfare and alienated many consumers, reduced employment in Top End towns which once had abattoirs, and added risk to cattle business profitability by providing only one market outlet.

The only way to test an animal for rabies is on their brain tissue, which can not be done in a live animal.

In that outbreak, masked palm civets sold in live animal markets passed the virus to people.

«These predictive algorithms seem to do a good job when CRISPR is performed in cells or tissues in a dish, but whole genome sequencing has not been employed to look for all off - target effects in living animals,» says co-author Alexander Bassuk, MD, PhD, professor of pediatrics at the University of Iowa.

They can, although Jin cautions that pifithrins» activity against Zika has not been tested in living animals.

It has not yet been tested in living animals or humans.

Using a novel technology, it was possible to observe the processes prior to the occurrence of epileptic seizures in living animals.

But the effects of adenosine had never been demonstrated in live animals, says Robert McCarley, a neurophysiologist at Harvard Medical School.

This past spring, Peersen received a new National Institutes of Health grant to continue testing the genetic modification in live animals, in partnership with researchers at the University of Wisconsin.

Ebola may be scarce in living animals, but carcasses like that one practically explode with virus.

«These results suggest that the SCN is indeed responsible for the temperature resistance of circadian rhythms in live animals, and it shows us how important SCN coupling is,» says Blackshaw.

Other techniques exist for remotely controlling the activity of cells or the expression of genes in living animals.

But it wasn't clear from mouse experiments if the SCN was responsible for this resistance to strong temperature changes in living animals.

A team at Rockefeller University and Rensselaer Polytechnic Institute is developing a system that would make it possible to remotely control biological targets in living animals — rapidly, without wires, implants or drugs.

To better determine the role of specific chemoattractants in type III hypersensitivity, lead author Yoshishige Miyabe, MD, PhD, a research fellow in Luster's lab, used multiphoton intravital microscopy — an imaging technology pioneered for studies of immune cell movements in living animals by CIID investigator and co-author Thorsten Mempel, MD, PhD — to follow in real time the development of IC - induced arthritis in a mouse model of rheumatoid arthritis.

Using a novel approach for imaging the movement of immune cells in living animals, researchers from the Massachusetts General Hospital (MGH) Center for Immunology and Inflammatory Diseases (CIID) have identified what appear to be the initial steps leading to joint inflammation in a model of inflammatory arthritis.

Now scientists are figuring out how to observe astrocytes in living animals and learning even more about the cells» abilities.

«Our study is the first to demonstrates unambiguously the conversion of a specific subtype of glia, the so - called NG2 glia, into induced neurons in living animals,» says senior study author Benedikt Berninger of Johannes Gutenberg University Mainz.

In living animals, a selfish bit of DNA called R2d2 is an outright lawbreaker.

Finally, the researchers tested this circuitry in live animals, artificially turning on the motor neurons in anesthetized mice and then looking to see how the auditory cortex responded.

Vertebrate evolution generally proceeds at far less than a snail's pace, making study of the process in living animals difficult at best.

The ability to automate morphology assays on 3D cell cultures is a powerful tool, but some scientists are now pushing the technology even further, with algorithms that can classify structures in living animals and clinical specimens.