Sentences with phrase «in luminal»

Solar cycles of magnetic variability result in changes in the luminal spectra of the sun, the properties of the solar wind, and the flux of galactic cosmic rays incident on Earth's atmosphere.

Reviewer # 1 also had concerns that the degree of knockdown of MELK by shMELK in the basal cell lines appears stronger than in the luminal cell lines, equivalent knockdown needs to be demonstrated by both quantitative protein and mRNA analysis.

It could be that the degree of knockdown of MELK in the luminal cell lines did not go below a necessary threshold to cause a proliferation effect.

Given MELK is a cell cycle regulated genes, it would be important for the authors to test whether MELK expression levels in luminal and basal cell lines (Figure 4B) is correlated with their doubling time.

We argue instead that the epithelial cells - especially in the luminal compartment - should rather be conceptualised as being part of a continuous spectrum of differentiation.

The observed mutation rate in coding regions seems to reflect the aggressiveness of breast cancer subtypes: lower in luminal A (0.84 mutations / Mbp) than luminal B (1.36 mutations / Mbp), higher in Her2 - enriched (2.05 mutations / Mbp) and Basal - like (1.68).

Figure 5 shows how key pathways are altered in luminal (first % box) and basal (middle box) breast cancer and ovarian cancer (right box).

Those clear patterns were not seen in the luminal cancers.

«It was really surprizing to realize that oncogenic Pik3ca in basal cells induced the formation of luminal tumours, while its expression in luminal cells gave rise to heterogeneous and more aggressive tumors including basal - like tumors,» comments Alexandra Van Keymeulen, the first author of the paper.

Not exact matches

In this study published in Cell Reports, Alexandra Van Keymeulen and colleagues generated a new transgenic line - allowing lineage tracing of ER + luminal cells to investigate luminal cell heterogeneity and identify the origin of ER + luminal cells and the mechanisms regulating their pubertal expansion and adult maintenancIn this study published in Cell Reports, Alexandra Van Keymeulen and colleagues generated a new transgenic line - allowing lineage tracing of ER + luminal cells to investigate luminal cell heterogeneity and identify the origin of ER + luminal cells and the mechanisms regulating their pubertal expansion and adult maintenancin Cell Reports, Alexandra Van Keymeulen and colleagues generated a new transgenic line - allowing lineage tracing of ER + luminal cells to investigate luminal cell heterogeneity and identify the origin of ER + luminal cells and the mechanisms regulating their pubertal expansion and adult maintenance.

The team also looked at the levels of the TAZ gene in tumors from women with either luminal or basal tumors.

The research team found that the experimental group had an imbalance of cell populations in breast tissue: too many luminal and too few basal.

«This opens up the possibility that cancer subtype - specific signaling is driven by STAT3 and that STAT3 inhibitors may be more effective in patients diagnosed with basal - like cancers than in those with luminal cancers,» Horvath said.

Horvath and Tell identified 84 genes that are expressed differently in basal - like cancer tumors as compared to luminal cancer tumors.

In breast tissue, there are two main types of cells: luminal cells and basal cells.

The results suggest a clinical study should be conducted of a STAT3 - inhibiting drug in patients with basal - like and luminal cancers, Horvath said.

Recent studies have implicated luminal progenitor cells in the development of breast cancers with a mutated BRCA1 gene.

Intriguingly, previous research found that RASAL2 was lost in some of the luminal type of breast tumours, where it acts as a tumour suppressor.

Humans have an ortholog of the murine Nrk gene, and considering that the gene expression pattern in breast tumor in Nrk mutant mice was similar to that in human luminal B breast cancer, the findings of this study may lead to further understanding of the mechanisms of human breast cancer suppression and to advances in its diagnosis and therapy.

Luminal A tumors are the most prevalent (44 % in this study), followed by luminal B Luminal A tumors are the most prevalent (44 % in this study), followed by luminal B luminal B (24 %).

LumeNEXT: A Practical Method to Pattern Luminal Structures in ECM Gels.

Additional insight into the biology of ER - positive breast cancers, particularly the higher risk luminal B cancers, could aid in identifying potential targets and new, effective therapies.

Intriguingly, luminal breast cancer cells, which are associated with a much better clinical prognosis, carry this gene in a state in which it seems to be permanently shut down.

Title: Developmental stage - specific contribution of LGR5 + cells to basal and luminal epithelial lineages in the postnatal mammary gland Authors: de Visser KE, Ciampricotti M, Michalak EM, Wei - Min Tan D, Speksnijder EN, Hau C - S, Clevers H, Barker N, Jonkers J Date: 2012 Publication Details: The Journal of Pathology 2011 May; 224 (1): 56 - 66

Cells from basal cancers are able to switch relatively easily into cancer stem cell (CSC) state, unlike luminal breast cancer cells, which tend to remain in the non-CSC state.

, van Boxtel, R., Wongvipat, J., Dowling, C.M., Gao, D., Begthel, H., Sachs, N., Vries, R.G., Cuppen, E., Chen, Y., Sawyers, C.L., Clevers, H.C. Identification of multipotent luminal progenitor cells in human prostate organoid cultures.

This luminal progenitor compartment undergoes transcriptional changes in response to a full pregnancy, lactation and involution.

Both reviewers consider that since the functional studies were only tested in 2 basal and 2 luminal breast cancer cell lines, the sample set was too small, and testing additional cell lines for their dependency on MELK should further strengthen the authors conclusions.

In contrast, in five luminal breast cell lines, MELK knockdown with equivalent efficiency did not result in obvious inhibition on cell growth (Figure 5E, Figure 5 — figure supplement 1A, BIn contrast, in five luminal breast cell lines, MELK knockdown with equivalent efficiency did not result in obvious inhibition on cell growth (Figure 5E, Figure 5 — figure supplement 1A, Bin five luminal breast cell lines, MELK knockdown with equivalent efficiency did not result in obvious inhibition on cell growth (Figure 5E, Figure 5 — figure supplement 1A, Bin obvious inhibition on cell growth (Figure 5E, Figure 5 — figure supplement 1A, B).

Mammary progenitors identified by a new marker, ICAM - 1, undergo epithelial - mesenchymal transition and luminal - to - basal switch in response to paracrine Met activation.

Our bioinformatics analysis, based on multiple independent large - size cohorts shows that MELK is strongly overexpessed in BBC / TNBC, not only compared to normal breast tissues, but also compared to luminal or ER / PR + breast cancer.

Consistent with this observation of MELK overexpression in BBC, we found that MELK expression in breast tumors has a significant inverse correlation with the expression of luminal markers, including estrogen and progesterone receptors (ER, PR)(Figure 2F, Figure 2 — figure supplement 1F).

Research has revealed that omega - 3 fatty acids are more effective in stopping or slowing the growth in the number of triple - negative breast cancer cells in comparison to cells from luminal categories of breast cancer.

Resulting increases in permeability allow for luminal factors (intestinal contents) to access the immune system and to set off autoimmune and inflammatory processes.

Chronic psychological stress in rats induces intestinal sensitization to luminal antigens.

GALT interacts strictly with gastrointestinal functions in a dynamic manner; for instance, by increasing intestinal permeability in replay to particular stimulations, or orientating the immune response towards luminal content, allowing either tolerance or elimination / degradation of luminal antigens, or sometimes provoking damage to the intestinal mucosa, such as in coeliac disease or food allergy.

If this surface breaks down, your immune system will get activated and start reacting to foods, toxins, and bugs in your gut [luminal contents].

According to Rapin and Wiernsperger (2010), «Tight junctions play a major role in regulating the paracellular passage of luminal elements» (p. 635).

Between Celiac Disease and Irritable Bowel Syndrome: The «No Man's Land» of Gluten Sensitivity https://www.nature.com/articles/ajg2009188 «We discuss the hypothesis that GS and post-infectious irritable bowel syndrome (IBS) provide two triggers that can explain at least part of the spectrum that constitutes IBS, further advancing an understanding of the role of mucosal responses to luminal factors in FBDs.»

In addition, curcumin significantly improves barrier function, reducing translocation of lipopolysaccharide (LPS), the outer cell wall of gram - negative bacteria, from the luminal surface of the intestine into circulation (Ghosh et al., 2014).

Blind loops are very uncommon in small animal gastroenterology but overgrowth probably occurs when partial obstructions in dogs and cats cause luminal contents to stagnate.

The use of soluble (fermentable) fiber in preference to insoluble (non-fermentable) fiber is sometimes advocated because most soluble fibers generate butyrate, the principle source of energy for the colonocyte, and other short - chain fatty acids.23 Short - chain fatty acids may lower the colonic luminal pH, impeding the growth of pathogens.23 The use of dietary fiber can have deleterious consequences.

Proposed causes for human IBD include defective immunoregulation of the gut - associated lymphoid tissue that may be precipitated by permeability defects, 14 infectious and parasitic agents, 15,16 and dietary allergies.13, 17 There is provocative evidence from clinical observations and animal models to incriminate normal luminal bacteria or bacterial products in the initiation and perpetuation of canine IBD.18, 19 The clinical response to hypoallergenic or elimination diets suggest that dietary factors may influence the pathogenesis of canine IBD.8 - 11 The term «hypoallergenic» refers to a diet that is generally free of additives and preservatives, and contains a hydrolyzed protein source.

Hyper Luminal Games are also planning to release the game on the Nintendo Switch in Q1 2019.

His site - specific constructed installations investigate non-objective abstraction and perceptual qualities in constructed environments that reconstructs architectural space in a blend of minimalism, process art and kinaesthetic experience that incorporates immersive light, sensory perception and luminal effects of uniform light (Ganzfelds).

Through geographic and chronological investigation of human experiences and material cultures, Tang creates luminal areas to recontextualize and compare systems of cultures in his multi-disciplinary artistic production that include video, sound, and graphic and sculptural installation.

Oscar for Meaning - Making: The Lovely Bones: After a zestful adolescent girl is murdered, she goes to a luminal, in - between place in which she fails to let go and struggles in vain to help her family cope with the loss.