Sentences with phrase «in lung»

A subset of these changes was much more prevalent in lung - cancer patients than cancer - free smokers.

The same benefits of increased activity observed in lung cancer patients, especially improved symptoms and quality of life, appear to apply to lung cancer survivors as well.

They also investigated the clinical features of these subtypes and whether there is any association with changes in genes and decline in lung function.

It is only present at low levels in lung cancer cells which are not metastatic and remain within the lung.

And pinpointing a genetic signature, such as EGFR mutations in lung cancer or HER2 mutations in breast cancer, can guide therapy decisions.

By tracking the mortality rates of people exposed to arsenic - contaminated drinking water in a region in Chile, the researchers provide evidence of increases in lung, bladder, and kidney cancer even 40 years after high arsenic exposures ended.

«Screening with an electronic stethoscope may be able to detect early changes in lung function in individuals without symptoms of lung disease.»

This is the first study looking at breath temperature as a marker in lung cancer.

Patients with this condition often have a history of acute pulmonary embolism, or blood clots in the lung.

«Rare mutation may extend survival in lung cancer patients with brain metastases.»

The researchers also found that AIP - 2 shifted the balance of different immune cells, including T cells and dendritic cells, which seemed to help suppress harmful immune reactions in the lung.

The study, called «Molecular Determinants of Drug - Specific Sensitivity for Epidermal Growth Factor Receptor (EGFR) Exon 19 and 20 Mutants in Non-Small Cell Lung Cancer,» and published online in the journal Oncotarget, demonstrates how computer modeling of EGFR mutations found in lung cancer can elucidate their molecular mechanism of action and consequently optimize the selection of therapeutic agents to treat patients.

Their findings, described in and featured on the cover of the current issue of Genes and Development, reveal that many of these lncRNAs in the lung regulate gene expression by opening and closing the DNA scaffolding on neighboring genes.

This leads to recurrent life - threatening lung infections, which result in lung damage that causes 90 % of deaths in people with cystic fibrosis.

NANCI appears to act upstream of Nkx2.1, but down - stream of Wnt signaling, a critical pathway for specifying cell type later in lung tissue development.

a) The Eye in your Thigh: a patch of skin cells on the leg that can distinguish between bright and dark conditions, perhaps to help regulate the body clock b) The Ear in your Rear: nerves in the buttocks attuned to infrasound vibrations of between 10 and 25 hertz, perhaps to warn of approaching predators or thunderstorms c) The Nose in your Toes: scent - detecting sebaceous glands on the feet whose purpose is unclear d) The Tongue in your Lung: taste - bud - like receptors that detect bitter substances and dilate or restrict the airways accordingly

But in lung samples from asthma patients, this reaction was much weaker.

Two groups decided to explore this idea more thoroughly in lung cells.

«ALK now becomes the second abnormal gene that we are able to successfully target in lung cancer with drugs other than chemotherapy.»

By identifying the cause of this metastasis — which often happens quickly in lung cancer and results in a bleak survival rate — Salk scientists are able to explain why some tumors are more prone to spreading than others.

By blocking these in lung endothelial cells, the researchers were able to slow lung tumor growth in mice and also reduce the spread of metastatic tumors.

The best results were seen in lung endothelial cells, but the particles also successfully delivered RNA to the kidneys and heart, among other organs.

The MRI imaging detected metastatic tumors, including micrometastases, in lung, liver, lymph node, adrenal gland, bone, and brains of the mice.

To demonstrate the potential for treating lung disease, the researchers used the nanoparticles to block two genes that have been implicated in lung cancer — VEGF receptor 1 and Dll4, which promote the growth of blood vessels that feed tumors.

In this lung organoid grown in Hans Clevers's lab, cells colored green are infected with respiratory syncytial virus.

Others note that the ability to re-create conditions closer to the sputum in the lung of a CF patient will lead to better understanding of how different strains of the bacterium behave.

«Cells in the lung can gobble up the silica, but it's so toxic, it kills these cells,» Harkema said.

At Brigham and Women's, she led clinical trials in lung transplants and found herself happily pursuing a career in «translational» research that applied basic science to clinical studies.

Trapnell and Suzuki were prompted to test the novel macrophage transplantation therapy by studies showing that resident macrophage populations (such as those residing in the lung) can self - maintain without the cells having to regenerate directly from the bone marrow.

«I've never seen such a dramatic protective response in the lung before.»

«These findings show that miR - 486 serves a tumor - suppressor function in lung cancer, and that miR - 486 action is partially dependent on p53.»

In lung biopsies and serum, they found that CHI3L1 levels are elevated in both tissue compartments in the outpatients with IPF and that the levels of CHI3L1 correlated with their disease progression.

«Fumes from military small arms lead to decline in lung function.»

New research shows that microRNA - 486 is a potent tumor - suppressor molecule in lung cancer, and that the it helps regulate the proliferation and migration of lung - cancer cells, and the induction of programmed cell death, or apoptosis, in those cells.

In particular, the researchers identified complex indels in the gene EGFR, which is implicated in lung cancer.

«This is critical in removing bacteria from sequestered spaces in the lung,» he says.

The Food and Drug Administration has issued a «Black Box» warning about the use of sirolimus in lung transplant patients, at least when started at the time of transplantation.

«MicroRNA molecule found to be potent tumor - suppressor in lung cancer.»

Exposure to fumes released during the firing of military small arms can lead to a decline in lung function, according to a new study.

«It wasn't known whether miR - 486 functioned as an oncogene or a tumor - suppressor gene in lung cancer,» says co-corresponding author Patrick Nana - Sinkam, MD, associate professor of medicine and a researcher with the OSUCCC — James Molecular Biology and Cancer Genetics Program.

In lung tissue, damage repair means a buildup of scar tissue, which compromises the lung.

Terry Dwyer, director of the centre, says that more research will be needed before the jump in lung cancer in women under 45 can be blamed primarily on smoking.

The study also looked at smokers without airway obstruction to determine whether acute respiratory events were associated with a decline in lung function.

«In this study we found that NF - κB activity is strongly associated with immune system T - cell infiltration in lung cancer,» explained study co-author Dung - Tsa Chen, Ph.D., member of the Biostatistics Department at Moffitt.

Their finding — that the presence of high levels of NF - κB in lung cancer tumors can act as a suppressor — provides new insight into how tumor pathways regulate the anti-tumor response.

However, Esther and the UNC coauthors, who were not involved in the clinical trial, said that a statistically significant increase in lung function is thought to lead to fewer CF - related flare - ups over the course of a year.

The chloride channel TMEM16A can be found in different organs of the body and plays a key role in the secretion of chloride in the lung, the contraction of smooth muscles, and the perception of pain.

While most of the work was done in the lab, Ahuja says her colleagues have already started to put the panel into use in a lung cancer trial.

This leads to dehydration of the mucus layer in the lung.

Inflammatory processes in lung tissue play a crucial role in the development of COPD.