The National Lung Screening Trial (NLST) reported a reduction
in lung cancer mortality in high - risk participants aged 55 to 74 who were randomly assigned to screening with low - dose computed tomography (LDCT) versus chest radiography.
In a study in the current issue of the American Journal of Preventive Medicine, researchers found that women working rotating night shifts for five or more years appeared to have a modest increase in all - cause and CVD mortality and those working 15 or more years of rotating night shift work appeared to have a modest increase
in lung cancer mortality.
On the other hand, the continuing increase
in lung cancer mortality among European women represents a challenge for cancer control, and the steady increase in pancreatic cancer deserves high priority for research.»
Not exact matches
The importance of these neighbour proteins was also seen
in other networks constructed for breast
cancer, hepatocellular carcinoma and non-small cell
lung cancer, other «solid»
cancers where new drugs are needed to tackle high
mortality rates.
By tracking the
mortality rates of people exposed to arsenic - contaminated drinking water
in a region
in Chile, the researchers provide evidence of increases
in lung, bladder, and kidney
cancer even 40 years after high arsenic exposures ended.
There was no association between rotating shift work and any
cancer mortality, except for
lung cancer in those who worked shift work for 15 or more years (25 % higher risk).
One of the fastest expanding types of
cancer in the developed world, malignant melanoma has a high
mortality rate — which is one reason that researchers at Sahlgrenska Academy were so anxious to follow up on the
lung cancer studies.
Lung cancer mortality rates among young women (30 - 49 years) were stable or declining
in 47 of the 52 populations examined.
Lung cancer mortality rates (per 100,000) during 2006 - 2010 ranged from 0.7
in Costa Rica to 14.8
in Hungary among young women and from 8.8
in Georgia to 120.0
in Scotland among older women.
«
Lung Cancer Mortality and Exposure to Radon Progeny
in a Cohort of New Mexico Underground Uranium Miners,» J.M. Samet, D.R. Pathak, M.V. Morgan, C.R. Key, A.A. Valdivia, and J.H. Lubin; Health Physics, Vol.
Fig 3 Effect of continued smoking on all cause
mortality, development of a second primary, or recurrence
in small cell
lung cancer.
No study contained data on the effect of quitting smoking on
cancer specific
mortality or on development of a second primary tumour
in non-small cell
lung cancer.
The biological mechanisms by which toxins
in tobacco smoke cause
lung cancer are complex and still not completely understood, but carcinogens
in tobacco smoke may not only act as genetic inducers but also act to promote progression of the disease.6 7 As well as potentially reducing the risk of
cancer related morbidity and
mortality, quitting smoking at diagnosis could reduce overall
mortality, as smoking cessation reduces
mortality from other diseases such as heart disease, stroke, and chronic obstructive airways disease.8 9
It can pick up early
lung cancers and can reduce
mortality from
lung cancer by about 20 %, but a large number of the early lesions that are seen probably never would go on to being lethal
cancer and being able to discriminate between those that will cause trouble and those that won't make a huge difference
in cancer therapy.
Four studies reported estimates of the association between continued smoking and all cause
mortality, one study reported the association with occurrence of a second primary tumour, and one study with recurrence
in non-small cell
lung cancer (fig 2 ⇓).
Cancer treatment has come on leaps and bounds in recent years, but mortality rates in lung and breast cancer are still
Cancer treatment has come on leaps and bounds
in recent years, but
mortality rates
in lung and breast
cancer are still
cancer are still high.
Researchers were able to confirm a direct association between animal - based low - carb diets
in males and increased
cancer mortality, especially from colorectal and
lung cancer.
High quercetin intake (mainly from apples and onions) was associated with lower asthma incidence and lower
mortality from ischemic heart disease
in general population, and
in lower incidence of
lung cancer in men.
Study after study has shown that increased consumption of cruciferous vegetables — including broccoli, Brussels sprouts, cabbage, mustard greens and kale — is strongly associated with reductions
in mortality — and offers particular protection against
cancers of the breast, prostate, bladder and
lung.
It is very well worth noting that consumption of red meat prepared
in different ways has been associated with a higher risk of colon, liver,
lung, and esophagus
cancer, the possibility of developing type 2 diabetes, and
mortality in the past.
In rural areas, liver,
lung, and stomach
cancers each accounts for close to 20 percent of
cancer mortality.
Evidence also exists of associations with low birth weight, increased infant and perinatal
mortality, pulmonary tuberculosis, nasopharyngeal and laryngeal
cancer, cataract, and, specifically
in respect of the use of coal, with
lung cancer... Exposure to indoor air pollution may be responsible for nearly 2 million excess deaths
in developing countries and for some 4 % of the global burden of disease.
Moreover, the paper gets its history wrong when it notes that «Total
cancer mortality rates did not decline until 1990, 25 years after the identification of the effect of smoking on
lung and other
cancers...» Well, actually, it was more like 50 years, because the earliest studies to connect smoking and
lung cancer were conducted not by NIH - funded scientists but by Nazi scientists
in the run - up to World War II.4 By the logic of the PNAS paper, then, ought we to be crediting the Nazi health science agenda with whatever progress has been made on reducing
lung cancer, rather than the incredibly protracted and difficult public health campaign (that, for the most part, NIH had nothing to do with) aimed at getting people to cut down on smoking?
According to the World Health Organization, they are now recognized as causing «respiratory and cardiovascular morbidity, such as aggravation of asthma, respiratory symptoms and an increase
in hospital admissions;
mortality from cardiovascular and respiratory diseases and from
lung cancer.»
Felitti and colleagues1 first described ACEs and defined it as exposure to psychological, physical or sexual abuse, and household dysfunction including substance abuse (problem drinking / alcoholic and / or street drugs), mental illness, a mother treated violently and criminal behaviour
in the household.1 Along with the initial ACE study, other studies have characterised ACEs as neglect, parental separation, loss of family members or friends, long - term financial adversity and witness to violence.2 3 From the original cohort of 9508 American adults, more than half of respondents (52 %) experienced at least one adverse childhood event.1 Since the original cohort, ACE exposures have been investigated globally revealing comparable prevalence to the original cohort.4 5 More recently
in 2014, a survey of 4000 American children found that 60.8 % of children had at least one form of direct experience of violence, crime or abuse.6 The ACE study precipitated interest
in the health conditions of adults maltreated as children as it revealed links to chronic diseases such as obesity, autoimmune diseases, heart,
lung and liver diseases, and
cancer in adulthood.1 Since then, further evidence has revealed relationships between ACEs and physical and mental health outcomes, such as increased risk of substance abuse, suicide and premature
mortality.4 7