Forkhead Box F1 represses cell growth and inhibits COL1 and ARPC2 expression
in lung fibroblasts in vitro.
Not exact matches
FGFR inhibitors are a new family of targeted agents designed to inhibit the action of the
fibroblast growth factor receptor, which is often overexpressed
in lung, bladder, biliary and breast cancers.
The experiments, including studies conducted
in a bioengineered 3 - D model of
lung tissue seeded with relevant cells, showed that CHI3L1 regulates a pathway that recruits cells such as macrophages and
fibroblasts that produce the scarring, or fibrosis.
This experiment uses quantitative PCR to detect the expression level of POSTN
in CD34 + / CD31 − pulmonary
fibroblasts, CD31 + endothelial cells, and CD45 + immune cells isolated from
lungs of mice with macrometastases, which is a replication of the experiment reported
in Figure 2H.
Function, activity, and membrane targeting of cytosolic phospholipase A2ζ
in mouse
lung fibroblasts.
Lung fibroblasts accelerate wound closure
in human alveolar epithelial cells through hepatocyte growth factor / c - Met signaling.
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Fibroblasts are also abundant and integrally involved
in many other tissues, including skin, breast,
lung and some cancers.
Normal human
lung fibroblasts (NHLF) cells grown
in 384 - well Optilux plates were treated with candidate compounds and incubated for 18 hours prior to fixation and staining with Hoescht dye and anti-HMOX1 antibody as described
in Materials and Methods.
A recent report demonstrated a significant increase
in COX2 expression
in normal
lung fibroblasts when exposed to cigarette smoke extracts [46].