Sentences with phrase «in lymphoid»

After ingestion, the virus replicates in the lymphoid tissues, and causes suppression of the immune system.

Cancer can originate in any lymphoid tissue.

The cells are normally found in lymphoid tissue, and within mucosal surfaces such as the intestine.

The first step in infection of a dog is when the canine parvo virus is ingested and it replicates in the lymphoid tissue located in the dog's throat.

The bacteria then penetrate the intestines where it multiplies in lymphoid tissue.

Highlight potential future therapies or therapeutic targets that are likely to be important in lymphoid malignancies.

Hodgkin lymphoma (HL) is a lymphoproliferative disease arising in the lymphoid tissue, which is characterized by Reed - Sternberg cells.

Amplification of the JAK2 locus has been described in Hodgkin disease and mediastinal B - cell lymphoma, 18,19 and biallelic inactivating mutations in suppressor of cytokine signaling - 1 (SOCS - 1), a negative regulator of JAK2, have been identified in mediastinal B - cell lymphoma.20 Genomic analysis of JAK2 and of other JAK - STAT pathway members may lead to the identification of mutations of the JAK - STAT pathway in lymphoid diseases and other malignancies.

These data indicate that the JAK2V617F allele is present in acute and chronic myeloid malignancies but not in lymphoid malignancies.

Each single multiplex master mix for TRB targets the conserved regions within the Vb and the Jb regions described in lymphoid malignancies.

Leukemia that starts in lymphoid cells — which make different types of white blood cells — is called lymphocytic or lymphoblastic leukemia.

What's more, the discovery of such a fundamental difference in the biology of blood and lymphoid tissue CD4 T cells opens the door to retesting drugs in lymphoid tissue that were deemed ineffective in blood cells.

The reservoir of latent HIV in the gut is poorly understood, especially because resting memory T cells in the gut are different than those in lymphoid tissues and blood.

Decrease in Lymphoid Specific Helicase and 5 - hydroxymethylcytosine Is Associated with Metastasis and Genome Instability Jiantao Jia, Ying Shi, Ling Chen, Weiwei Lai, Bin Yan, Yiqun Jiang, Desheng Xiao, Sichuan Xi, Ya Cao, Shuang Liu, Yan Cheng, Yongguang Tao Theranostics 2017; 7:3920 - 3932

The key observation of this study was that MSCs infused pretransplant localize in the lymphoid organs whereas MSC administered posttransplant are recruited to the graft [syngeneic or allogeneic].

This activation takes place in vivo in lymphoid tissues such as the lymph nodes and tonsils.

The frequency of CD39highCD8 + T cells increased with tumor growth but was absent in lymphoid organs.

Lyt phenotype of T cells in lymphoid tissues and blocking of tumor rejection.

IL - 15 is a pleiotropic cytokine, with proposed roles in both lymphoid and non-lymphoid tissues.

In mice with an artificial fever, more lymphocytes (green) adhered to blood vessels (red) in lymphoid organs and crossed the vessels into lymphoid tissue.

In HIV - infected patients undergoing antiretroviral therapy (ART), ongoing HIV replication in lymphoid tissues such as the lymph nodes helps maintain stores, or reservoirs, of the virus, a new study funded by the National Institutes of Health suggests.

In this study, researchers demonstrated that continued HIV replication in lymphoid tissue sanctuaries refills viral reservoirs in patients on ART who have achieved undetectable blood levels of HIV.

Previous work had suggested that antiretroviral drug concentrations are lower in lymphoid tissue than in blood, and that HIV can hide in sanctuaries that drugs do not penetrate well.

When injected together with factor VIII into mouse models of haemophilia A, the nanoparticles deliver their payload to cells in the lymphoid tissue that are responsible for initiating immune responses.

«Their properties and the ability to induce these cells by vaccination provide a tremendous opportunity to target and reduce the viral reservoir in lymphoid tissues.»

The disease originates in a lymphoid organ (lymph node, spleen, or bone marrow) before spreading through the blood to infiltrate not only other lymphoid organs but also other tissues.

«The fundamental «killing units» of CD4 T cells in lymphoid tissues are other infected cells, not the free virus,» says co-first author Gilad Doitsh, PhD, a staff research investigator at the Gladstone Institute of Virology and Immunology.

Fully implemented targeted sequencing - based assays in routine diagnostic pathology laboratories are currently lacking in lymphoid cancer care,» explained Christian Steidl, MD, Senior Scientist at the BC Cancer and Associate Professor in the Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada.

The research suggests there are more people infected in lymphoid tissues, who may never develop the disease but could still infect others via blood transfusions or organ donations

But the bottom line is that about two thirds of all T cells reside in the lymphoid tissue of the gut, where the virus spreads after exposure, even before it shows up in blood.

Not exact matches

About 80 % of our immune system resides in our gut, specifically in the GALT (gut - associated lymphoid tissue), which protects the body from invasion of pathogenic bacteria, fungi, and viruses.

In contrast, examination of the same section of small intestine after the infant is born and has begun breast - feeding reveals proliferating, mature epithelium with enterocyte differentiation and abundant lymphoid tissue.

Thus, Jak3 plays a critical role in γc signaling and lymphoid development.

A new study published in The Journal of Molecular Diagnostics has established that hybrid - capture sequencing is the method of choice for sequencing «actionable» gene mutations across the most common forms of lymphoid cancer.

«Harnessing the power of genomic sequencing augments diagnosis and treatment of lymphoid cancer: New assay may allow screening for «actionable» gene mutations in routinely acquired archival biopsies, reports The Journal of Molecular Diagnostics.»

Embedded in the bulbar surface is a dense population of lymphoid follicles that are in contact with the surface of the eye and the tear film, a thin layer of liquid.

Antibody formation against sheep erythrocytes by mouse spleen cells in vitro requires interactions among antigen - treated macrophages and lymphoid cells in cell culsters for only a finite time.

Thus, natural antibodies play a crucial role by preventing pathogen dissemination to vital organs and by improving immunogenicity through enhanced antigen - trapping in secondary lymphoid organs.

«Although it's still early days for this line of research, these findings provoke the hypothesis that MHCII + innate lymphoid cells may be an important pathway to therapeutically target in the treatment of some chronic inflammatory diseases,» suggests Sonnenberg.

Further investigation revealed that the increased susceptibility was due to a reduction in production by the innate lymphoid cells of IL - 22, a protein that plays a key role in the intestinal immune response.

New research shows that all - trans - retinoic acid (atRA), the active form of vitamin A, regulates immune system responses in the mouse intestine by controlling expression of the protein HIC1 in cells known as innate lymphoid cells.

The researchers deleted the HIC1 gene in certain innate lymphoid cells in the mouse intestine and found that this increased the susceptibility of the mice to infection with the bacterium Citrobacter rodentium.

Gregory F. Sonnenberg, PhD, research associate in the Department of Medicine, Gastroenterology Division, and the Institute for Immunology at the Perelman School of Medicine, University of Pennsylvania, with postdoctoral researcher Matthew Hepworth, PhD, report in Nature that innate lymphoid cells (ILCs) directly limit the response by inflammatory T cells to commensal bacteria in the gut of mice.

Even at this stage, measuring the number of innate lymphoid cells in the blood makes it possible to provide a prognosis of the effects of treatment.

Type 3 ILCs (ILC3s) are in addition essential for the development of lymphoid organs such as lymph nodes and for tissue repair.

Innate lymphoid cells in the intestine of healthy mice.

«These findings will make it possible to significantly improve the quality of treatment of rheumatoid arthritis in future with the help of innate lymphoid cells,» says Dr Ramming.

Previous research has shown that atRA, produced from dietary vitamin A by some intestinal cells, helps maintain this balance in mice by regulating the activity of innate lymphoid cells.

According to Simon Rauber, an immunologist in Erlangen and primary author of the study, a previously inadequately studied cell population of the immune system called innate lymphoid cells plays a major role in the resolution of inflammations.

This temporary colonization of E.coli in the mother affected the immune system of her offspring; after birth, the offspring harbored more innate lymphoid and mononuclear cells in their intestines compared to mice born to microbe - free pregnant mothers.