Sentences with phrase «in lymphoid tissues»

After ingestion, the virus replicates in the lymphoid tissues, and causes suppression of the immune system.

The reservoir of latent HIV in the gut is poorly understood, especially because resting memory T cells in the gut are different than those in lymphoid tissues and blood.

This activation takes place in vivo in lymphoid tissues such as the lymph nodes and tonsils.

Lyt phenotype of T cells in lymphoid tissues and blocking of tumor rejection.

In HIV - infected patients undergoing antiretroviral therapy (ART), ongoing HIV replication in lymphoid tissues such as the lymph nodes helps maintain stores, or reservoirs, of the virus, a new study funded by the National Institutes of Health suggests.

«Their properties and the ability to induce these cells by vaccination provide a tremendous opportunity to target and reduce the viral reservoir in lymphoid tissues.»

«The fundamental «killing units» of CD4 T cells in lymphoid tissues are other infected cells, not the free virus,» says co-first author Gilad Doitsh, PhD, a staff research investigator at the Gladstone Institute of Virology and Immunology.

The research suggests there are more people infected in lymphoid tissues, who may never develop the disease but could still infect others via blood transfusions or organ donations

But the bottom line is that about two thirds of all T cells reside in the lymphoid tissue of the gut, where the virus spreads after exposure, even before it shows up in blood.

When injected together with factor VIII into mouse models of haemophilia A, the nanoparticles deliver their payload to cells in the lymphoid tissue that are responsible for initiating immune responses.

Previous work had suggested that antiretroviral drug concentrations are lower in lymphoid tissue than in blood, and that HIV can hide in sanctuaries that drugs do not penetrate well.

In this study, researchers demonstrated that continued HIV replication in lymphoid tissue sanctuaries refills viral reservoirs in patients on ART who have achieved undetectable blood levels of HIV.

What's more, the discovery of such a fundamental difference in the biology of blood and lymphoid tissue CD4 T cells opens the door to retesting drugs in lymphoid tissue that were deemed ineffective in blood cells.

Hodgkin lymphoma (HL) is a lymphoproliferative disease arising in the lymphoid tissue, which is characterized by Reed - Sternberg cells.

The bacteria then penetrate the intestines where it multiplies in lymphoid tissue.

The first step in infection of a dog is when the canine parvo virus is ingested and it replicates in the lymphoid tissue located in the dog's throat.

The cells are normally found in lymphoid tissue, and within mucosal surfaces such as the intestine.

Cancer can originate in any lymphoid tissue.

Not exact matches

About 80 % of our immune system resides in our gut, specifically in the GALT (gut - associated lymphoid tissue), which protects the body from invasion of pathogenic bacteria, fungi, and viruses.

In contrast, examination of the same section of small intestine after the infant is born and has begun breast - feeding reveals proliferating, mature epithelium with enterocyte differentiation and abundant lymphoid tissue.

The disease originates in a lymphoid organ (lymph node, spleen, or bone marrow) before spreading through the blood to infiltrate not only other lymphoid organs but also other tissues.

Type 3 ILCs (ILC3s) are in addition essential for the development of lymphoid organs such as lymph nodes and for tissue repair.

Immunologist Sharon Evans of Roswell Park Cancer Institute in Buffalo, New York, and coworkers are studying how fever affects the movement of white blood cells, or lymphocytes, from the blood into lymphoid tissue, where they learn to recognize and fight pathogens.

In mice with an artificial fever, more lymphocytes (green) adhered to blood vessels (red) in lymphoid organs and crossed the vessels into lymphoid tissuIn mice with an artificial fever, more lymphocytes (green) adhered to blood vessels (red) in lymphoid organs and crossed the vessels into lymphoid tissuin lymphoid organs and crossed the vessels into lymphoid tissue.

IL - 15 is a pleiotropic cytokine, with proposed roles in both lymphoid and non-lymphoid tissues.

Oral inoculation of mice with low doses of microencapsulated, noninfectious rotavirus induces virus - specific antibodies in gut - associated lymphoid tissue.

Induction of rotavirus - specific memory B cells in gut - associated lymphoid tissue after intramuscular immunization.

Rotavirus - specific proteins are detected in murine macrophages in both intestinal and extraintestinal lymphoid tissue.

Distribution of rotavirus - specific memory B cells in gut - associated lymphoid tissue after primary immunization.

Tissue - cultured corneal cells were used for in vitro studies rather than the usual lymphoid cells since corneal cells are the relevant target cells in vivo during corneal allograft rejection.

Finally, the HZI will help develop in vivo imaging technologies to characterize (i) vaccine biodistribution and persistence, and (ii) cellular and molecular changes at the injection site and in draining lymphoid tissues, helping to refine the use of animal models.

lymphocyte - a white blood cell present in the blood, lymph and lymphoid tissue that is essential in immune defense.

In pathological conditions, MSCs migrate preferentially into lymphoid organs, allografts, injured and / or inflammatory tissue sites after systemic transfusion, where they interact with the activated immune cells and modulate their function 51, 52.

[31] Recent studies show that the vaginal mucosa can support T - cell induction in the absence of MALT or secondary lymphoid tissues, suggesting that the type II vaginal mucosa can itself act as an inductive site for the generation of primary CD8 + T - cell immune responses.

To the identify the tissue - wide expression pattern of this receptor, they screen the full human tissue atlas and find expression in a limited number of normal tissues and cancers, including some reproductive and lymphoid organs and cancers.

In a curious twist resembling cellular alchemy, when blood T cells are cultured with lymphoid tissue from the tonsils or spleen, the blood T cells begin acting like lymphoid tissue T cells, becoming more activated and more susceptible to abortive infection and death by pyroptosis.

The scientists say the latest findings, published in the journal Cell Host & Microbe, should spark greater use of lymphoid tissue T cells to study the pathogenic effects of HIV.

Susan Amara, USA - «Regulation of transporter function and trafficking by amphetamines, Structure - function relationships in excitatory amino acid transporters (EAATs), Modulation of dopamine transporters (DAT) by GPCRs, Genetics and functional analyses of human trace amine receptors» Tom I. Bonner, USA (Past Core Member)- Genomics, G protein coupled receptors Michel Bouvier, Canada - Molecular Pharmacology of G protein - Coupled Receptors; Molecular mechanisms controlling the selectivity and efficacy of GPCR signalling Thomas Burris, USA - Nuclear Receptor Pharmacology and Drug Discovery William A. Catterall, USA (Past Core Member)- The Molecular Basis of Electrical Excitability Steven Charlton, UK - Molecular Pharmacology and Drug Discovery Moses Chao, USA - Mechanisms of Neurotophin Receptor Signaling Mark Coles, UK - Cellular differentiation, human embryonic stem cells, stromal cells, haematopoietic stem cells, organogenesis, lymphoid microenvironments, develomental immunology Steven L. Colletti, USA Graham L Collingridge, UK Philippe Delerive, France - Metabolic Research (diabetes, obesity, non-alcoholic fatty liver, cardio - vascular diseases, nuclear hormone receptor, GPCRs, kinases) Sir Colin T. Dollery, UK (Founder and Past Core Member) Richard M. Eglen, UK Stephen M. Foord, UK David Gloriam, Denmark - GPCRs, databases, computational drug design, orphan recetpors Gillian Gray, UK Debbie Hay, New Zealand - G protein - coupled receptors, peptide receptors, CGRP, Amylin, Adrenomedullin, Migraine, Diabetes / obesity Allyn C. Howlett, USA Franz Hofmann, Germany - Voltage dependent calcium channels and the positive inotropic effect of beta adrenergic stimulation; cardiovascular function of cGMP protein kinase Yu Huang, Hong Kong - Endothelial and Metabolic Dysfunction, and Novel Biomarkers in Diabetes, Hypertension, Dyslipidemia and Estrogen Deficiency, Endothelium - derived Contracting Factors in the Regulation of Vascular Tone, Adipose Tissue Regulation of Vascular Function in Obesity, Diabetes and Hypertension, Pharmacological Characterization of New Anti-diabetic and Anti-hypertensive Drugs, Hypotensive and antioxidant Actions of Biologically Active Components of Traditional Chinese Herbs and Natural Plants including Polypehnols and Ginsenosides Adriaan P. IJzerman, The Netherlands - G protein - coupled receptors; allosteric modulation; binding kinetics Michael F Jarvis, USA - Purines and Purinergic Receptors and Voltage-gated ion channel (sodium and calcium) pharmacology Pain mechanisms Research Reproducibility Bong - Kiun Kaang, Korea - G protein - coupled receptors; Glutamate receptors; Neuropsychiatric disorders Eamonn Kelly, Prof, UK - Molecular Pharmacology of G protein - coupled receptors, in particular opioid receptors, regulation of GPCRs by kinasis and arrestins Terry Kenakin, USA - Drug receptor pharmacodynamics, receptor theory Janos Kiss, Hungary - Neurodegenerative disorders, Alzheimer's disease Stefan Knapp, Germany - Rational design of highly selective inhibitors (so call chemical probes) targeting protein kinases as well as protein interaction inhibitors of the bromodomain family Andrew Knight, UK Chris Langmead, Australia - Drug discovery, GPCRs, neuroscience and analytical pharmacology Vincent Laudet, France (Past Core Member)- Evolution of the Nuclear Receptor / Ligand couple Margaret R. MacLean, UK - Serotonin, endothelin, estrogen, microRNAs and pulmonary hyperten Neil Marrion, UK - Calcium - activated potassium channels, neuronal excitability Fiona Marshall, UK - GPCR molecular pharmacology, structure and drug discovery Alistair Mathie, UK - Ion channel structure, function and regulation, pain and the nervous system Ian McGrath, UK - Adrenoceptors; autonomic transmission; vascular pharmacology Graeme Milligan, UK - Structure, function and regulation of G protein - coupled receptors Richard Neubig, USA (Past Core Member)- G protein signaling; academic drug discovery Stefan Offermanns, Germany - G protein - coupled receptors, vascular / metabolic signaling Richard Olsen, USA - Structure and function of GABA - A receptors; mode of action of GABAergic drugs including general anesthetics and ethanol Jean - Philippe Pin, France (Past Core Member)- GPCR - mGLuR - GABAB - structure function relationship - pharmacology - biophysics Helgi Schiöth, Sweden David Searls, USA - Bioinformatics Graeme Semple, USA - GPCR Medicinal Chemistry Patrick M. Sexton, Australia - G protein - coupled receptors Roland Staal, USA - Microglia and neuroinflammation in neuropathic pain and neurological disorders Bart Staels, France - Nuclear receptor signaling in metabolic and cardiovascular diseases Katerina Tiligada, Greece - Immunopharmacology, histamine, histamine receptors, hypersensitivity, drug allergy, inflammation Georg Terstappen, Germany - Drug discovery for neurodegenerative diseases with a focus on AD Mary Vore, USA - Activity and regulation of expression and function of the ATP - binding cassette (ABC) transporters

The aim of this study is to determine whether a 20 - week treatment course with 1 μg / kg / week of pegylated interferon alpha 2 b (peg - IFN - α2b) will reduce the levels of HIV - 1 proviral DNA levels in circulating PBMC and mucosa - associated lymphoid tissue (MALT) in HIV - infected individuals receiving long - term anti-retroviral therapy (ART).

We speculated that this could be due to the poor development of the lymphoid tissues in these mice rather than the inherent inability of the HPCs to develop into lymphoid cells.

As things make their way through your digestive system, your gut - associated lymphoid tissue, or GALT, which is the term for the immune system in your gut, reviews everything to check for potentially harmful substances.

Also called the lymphatic system, it is comprised of lymphatic vessels that run throughout the body (with the largest vessel being the thoracic duct, which collects a large portion of the body's lymph); lymph nodes, located in the neck, armpit, groin, and inside the center of the chest and abdomen; the tonsils and adenoids, which are collections of lymphoid tissue similar to lymph nodes; and the spleen and thymus, which are lymphoid organs.

The secondary lymphoid organs include lymph nodes, spleen, appendix, tonsils, adenoids and Peyer's patches (lymphoid tissue present in the small and large intestines).

With 70 % of it housed in the Gut Associated Lymphoid Tissue (GALT) in the intestinal wall, the ecosystem of microbial residents are responsible for influencing the immune gatekeepers such as dendritic cells.

These foreign particles really piss off your immune system, who's standing guard to protect you with 80 % of its soldiers right inside the gut wall in what's called the Gut Associated Lymphoid Tissue (GALT).

In all forms, the tumors consist of abnormal proliferation of lymphoid tissue.

The canine tonsils are lymphoid tissue and therefore, are important in fighting diseases.

Canine Lymphoma Lymphoma (lymphosarcoma) is a relatively common type of cancer found in dogs and cats which arises from lymphoid tissue.

Proposed causes for human IBD include defective immunoregulation of the gut - associated lymphoid tissue that may be precipitated by permeability defects, 14 infectious and parasitic agents, 15,16 and dietary allergies.13, 17 There is provocative evidence from clinical observations and animal models to incriminate normal luminal bacteria or bacterial products in the initiation and perpetuation of canine IBD.18, 19 The clinical response to hypoallergenic or elimination diets suggest that dietary factors may influence the pathogenesis of canine IBD.8 - 11 The term «hypoallergenic» refers to a diet that is generally free of additives and preservatives, and contains a hydrolyzed protein source.

The lymphoma can vary in aggression, although often will quickly go on to affect the primary and secondary lymphoid tissues.