Sentences with phrase «in lysosomal enzyme»

It's a metabolic storage disorder resulting in lysosomal enzyme deficiency, which affects nearly every system in the dog's body.

Not exact matches

Specifically, the current study demonstrated that an accumulation of oxidized dopamine depressed the activity of lysosomal glucocerebrosidase (GCase), an enzyme implicated in PD.

So the idea would be to identify the enzymes these organisms use to digest lysosomal wastes, modify them a bit to help them work in the slightly different environment of the human lysosome, and then deliver them to where they need to go in our cells.

If such enzymes didn't exist, then the planet would be ankle - deep in the undegraded lysosomal wastes left over from the cells of 600 million years of animal life on this planet.

Our lead candidate, LYS - GM101, has been designed to replace this defective gene in the cells of GM1 patients, in order to allow for production of the functional lysosomal acid beta - galactosidase (bgal) enzyme.

Furthermore, ApoE4 caused a disruption of lysosomal integrity and a shift in the localization of Cathepsin D, an enzyme known to degrade Trx1.

Lysis of these A beta 42 - burdened neurones apparently resulted in a local, radial dispersion of their cytoplasmic contents, including A beta 42 and lysosomal enzymes, into the surrounding extracellular space.

Quantitative Differences in the Urinary Proteome of Siblings Discordant for Type 1 Diabetes Include Lysosomal Enzymes.

Cutting Edge: Induction of the Antigen - Processing Enzyme IFN --LCB- gamma -RCB-- Inducible Lysosomal Thiol Reductase in Melanoma Cells Is STAT1 - Dependent but CIITA - Independent

The ensuing decrease in pH and / or the presence of the lysosomal enzymes such as cathepsin B lead to premature activation of trypsinogen.

The mucopolysaccharides, which aid in bone formation, as well as that of the skin, cornea and cartilage, don't perform their function properly because of a lack of lysosomal enzymes.

In the lipid storage form of lysosomal storage disease I mentioned that dogs and cats can be born with decreased or missing lysosome enzymes that allows them to process fatty substances (lipids).

It is difficult to treat abscesses in guinea pigs, because like rabbits, they lack a lysosomal enzyme that helps to break down pus.