Sentences with phrase «in lysosomes»

Not only did APP accumulate in lysosomes of mice lacking NEU1 but researchers found evidence that the build - up promoted the production of Aβ - 42 and other toxic peptides tied to Alzheimer's disease.

In ISSD and Salla disease, other sialic acid - related conditions, a transport malfunction causes sialic acid to accumulate in lysosomes.

We describe here that in cells derived from human monocytes, i.e., macrophages and dendritic cells, the B - subunit was internalized in a receptor - dependent manner, but retrograde transport to the biosynthetic / secretory pathway did not occur and part of the internalized protein was degraded in lysosomes.

The enzymes in the lysosome break down large biological molecules like proteins, carbohydrates, fats, nucleic acids, and membranes into their component parts.

Immature dendritic cells (DCs) sequester intact antigens in lysosomes, processing and converting antigens into peptide — MHC II complexes upon induction of DC maturation.

This accumulation takes place in the lysosomes, the «recycling plants» of the cells.

Cells use this process to repair the outer membrane of cells and to selectively expel material in lysosomes.

These studies revealed that loss of NEU1 activity was associated with a build - up in lysosomes of the amyloid precursor protein (APP), which they identified as a natural target of the enzyme.

Protein degradation was thought to occur in the lysosome, a pouch inside the cell that contains a multitude of protein - destroying enzymes.

The longer one fasts, the more parasitic bacteria are destroyed in lysosomes.

The Neuronal Ceroid Lipofuscinosis is characterized by accumulation of phospholipids in lysosomes of brain, retina and other tissues.

The team started searching for a drug that could prevent the accumulation of chemotherapy in the lysosomes, and found that the common beta blocker propranolol was effective in competing with the doxorubicin for lysosomal space.

The sequestered contents are degraded in the lysosome, allowing cells to eliminate damaged or harmful components through catabolism and recycling, to maintain nutrient and energy homeostasis [124].

Every enzyme in the lysosome is produced under the direction of a pair of genes.

PV - 10 (rose bengal disodium 10 %), a small - molecule fluorescein derivative, while excluded from normal cells, transits the plasmalemma of cancer cells and accumulates in lysosomes, triggering lysosomal release and complete autolysis within 30 to 60 minutes.

In the lysosome, bacteria are broken into their individual constituents, which can be reused by the body.

Mitochondria express eGFP and mCherry but in lysosomes the eGFP, green fluorescence is quenched.

Autophagy is a catabolic degradation process in which cellular proteins and organelles are engulfed by double - membrane autophagosomes and degraded in lysosomes.