Wagenseil's novel approach, recently published in Heart and Circulatory Physiology, focused on the genetic signaling and mechanical effects of mutations
in lysyl oxidase, or LOX.
Not exact matches
Copper is also necessary for the activity of
lysyl oxidase, an enzyme involved
in cross-linking collagen and elastin, both of which provide the ground substance and flexibility
in blood vessels, bones and joints.
The study,
Lysyl oxidase and adipose tissue dysfunction, found that this molecule is more prevalent
in fat tissue of obese people and that it was increased by inflammation and oxygen deprivation.
The research published
in the journal Metabolism, examined a molecule called
Lysyl oxidase (LOX) which regulates scarring by making tissue stiffer.
To help prevent such conditions, Iyer and colleagues at The University of Western Australia, Fiona Wood Foundation and Royal Perth Hospital Burns Unit, together with Pharmaxis Ltd., (all
in Australia) are studying compounds that inhibit an enzyme called
lysyl oxidase, or LOX.
«The preliminary data strongly suggest that
lysyl oxidase inhibition alters the collagen architecture and restores it to the normal architecture found
in the skin,» Iyer says.
MCF - 7 Cells Expressing Nuclear - associated
Lysyl Oxidase - like 2 (LOXL2) Exhibit an Epithelial - to - Mesenchymal Transition (EMT) Phenotype and are Highly Invasive
In Vitro.
• Copper — This mineral acts as a co-factor
in the enzyme
lysyl oxidase.
It is a cofactor
in several oxidative enzymes vital to the function of hematopoietic, vascular and skeletal tissues, as well as the structure and function of the nervous system, including superoxide dismutase (oxygen radical scavenger), cytochrome - c
oxidase (mitochondrial respiration),
lysyl oxidase (collagen and elastin synthesis) and ceruloplasmin ferroxidase / haephestin (iron metabolism).
In addition, copper is a cofactor for the activity of a vital enzyme called
lysyl oxidase.
Avocado oil was found
in the study above to decrease
lysyl oxidase activity.
The effects inside the body could be drastically different, but
in this instance, it's likely that applying avocado oil topically will inhibit
lysyl oxidase as well.
Copper is also necessary for the activity of
lysyl oxidase, an enzyme involved
in cross-linking collagen and elastin, both of which provide the ground substance and flexibility
in blood vessels, bones and joints.