A genomic revolution
in malaria research by Olivio Miotto Why would you focus malaria research on regions where there are very few cases of malaria?
«Dr. Cassera has taken a leap forward
in malaria research by identifying a unique pathway at an essential step in parasite development and transmission to mosquitoes,» said Vern Schramm, the Ruth Merns Chair and Professor of Biochemistry at the Albert Einstein College of Medicine, and former postdoctoral mentor to Cassera.
Not exact matches
The findings, described
in two related papers published online April 5
in Science and The Lancet, were called «a tour de force»
by David Sullivan, an associate professor at Johns Hopkins
Malaria Research Institute, who was not involved in the new r
Research Institute, who was not involved
in the new
researchresearch.
The
research was conducted
by the University of Cape Town (UCT)'s Drug Discovery and Development Centre, H3D, and Medicines for
Malaria Venture (MMV),
in collaboration with a team of international researchers.
For the
research, conducted in the insectary at the Johns Hopkins Malaria Research Institute in Baltimore, Dimopoulos and colleagues modified Anopheles gambiae mosquitoes by deleting the gene FREP1, which encodes an immune protein, fibrinogen - related pr
research, conducted
in the insectary at the Johns Hopkins
Malaria Research Institute in Baltimore, Dimopoulos and colleagues modified Anopheles gambiae mosquitoes by deleting the gene FREP1, which encodes an immune protein, fibrinogen - related pr
Research Institute
in Baltimore, Dimopoulos and colleagues modified Anopheles gambiae mosquitoes
by deleting the gene FREP1, which encodes an immune protein, fibrinogen - related protein 1.
Conducted
by Prof Rose McGready and Assoc. Prof Daniel Henry Paris from the Shoklo
Malaria Research Unit (SMRU)
in Mae Sot, Thailand, and the Mahidol Oxford
Research Unit (MORU)
in Bangkok, affiliated to Oxford University, UK,
in collaboration with Prof John Antony Jude Prakash of the Dept. of Clinical Microbiology, Christian Medical College, Vellore, India, the study, «Pregnancy outcome
in relation to treatment of Murine typhus and Scrub typhus infection: a fever cohort and a case series analysis,» will be published
in the November 20th, 2014 issue of PLOS Neglected Tropical Diseases.
The plan, to be carried out
by national
malaria - control agencies
in Cambodia and Thailand with support from various
research institutes, includes rapid and widespread treatment with ACTs, improved mosquito control, the distribution of long - lasting insecticide - impregnated bed nets, a ban on monotherapies
in Cambodia (they are already rare
in Thailand), and an information campaign.
Then
in 1985, a team led
by Ripley Ballou began human challenges with
malaria at the Walter Reed Army Institute of
Research (WRAIR)
in Silver Spring, Maryland.
Nonetheless, pointing to related studies under way and arguing that attention on how to protect pregnant women and their fetuses from
malaria must continue, Steketee concludes that «
by likely closing a door on IPTp with mefloquine, [the
research presented
in the two papers] opens other doors for further important work
in the coming years.»
For their studies on a species of human
malaria that is also carried
by monkeys, as part of a larger project funded
by the UK
Research Council Living with Environmental Change initiative, Fornace and her colleagues are using a drone to map changes
in mosquito and monkey habitats and correlate how those changes affect human infection.
Now, the Laboratory of
Malaria Immunology Team at the Immunology Frontier Research Center (IFReC), Osaka University, headed by Professor Cevayir COBAN, have used mouse malaria models to show that robust immune activation and invasion of parasite by - products into the bone marrow during and after malaria infection leads to an adverse balance in bone homeostasis - a process usually tightly controlled - by bone forming osteoblasts and bone resorbing osteo
Malaria Immunology Team at the Immunology Frontier
Research Center (IFReC), Osaka University, headed
by Professor Cevayir COBAN, have used mouse
malaria models to show that robust immune activation and invasion of parasite by - products into the bone marrow during and after malaria infection leads to an adverse balance in bone homeostasis - a process usually tightly controlled - by bone forming osteoblasts and bone resorbing osteo
malaria models to show that robust immune activation and invasion of parasite
by - products into the bone marrow during and after
malaria infection leads to an adverse balance in bone homeostasis - a process usually tightly controlled - by bone forming osteoblasts and bone resorbing osteo
malaria infection leads to an adverse balance
in bone homeostasis - a process usually tightly controlled -
by bone forming osteoblasts and bone resorbing osteoclasts.
Research led
by WorldPop, based at the University, examined and mapped the movement of the disease from endemic countries (those where
malaria is regularly found
in the population) to around 40 countries defined as being
malaria - free or non-endemic (such as the UK).
According to Neena Valecha of the National Institute of
Malaria Research in Delhi, India, who led the trial, arterolane may be available
by next year.
The MRC Centre for Genomics and Global Health (CGGH) is supporting MalariaGEN
by developing web - based applications for sharing and analysing large genomic datasets, and
by helping to build
research capacity for genetic epidemiology
research in malaria - endemic regions.
The members of the genus Aotus constitute one of the few species that are affected
by Plasmodium falciparum, making them suitable for non-human primate experimental models
in malaria research.
Genetic variability revealed
in malaria genomes newly sequenced
by two multi-national
research teams points to new challenges
in efforts to...
In his office at Mahidol University, Nick White is surrounded
by yellowing monographs of old
malaria research and overlooked
by a wall - mounted mosaic of drug packets made
by his daughter.
A key moment
in her
research occurred when she discovered that she could induce an immune response
in mice
by injecting them with an irradiated
malaria parasite.
TRAC is a large multi-centre collaboration coordinated
by Mahidol Oxford Tropical Medicine
Research Unit (MORU) in Bangkok, and comprises a range of research institutions as well as National Malaria Control Programmes and the World Health Organizatio
Research Unit (MORU)
in Bangkok, and comprises a range of
research institutions as well as National Malaria Control Programmes and the World Health Organizatio
research institutions as well as National
Malaria Control Programmes and the World Health Organization (WHO).
His current
research on Plasmodium genetics provides a strong link between the CGGH and the
malaria research programme
in The Gambia led
by Umberto d'Alessandro.
TRAC is a large - scale collaboration coordinated
by the Mahidol Oxford Tropical Medicine
Research Unit (MORU) in Bangkok, and comprises research groups and National Malaria Control Programmes in each of the study - site countries, along with the London School of Hygiene and Tropical Medicine (LSHTM), the Liverpool School of Tropical Medicine (LSTM), the WorldWide Antimalarial Resistance Network (WWARN) and the Global Malaria Programme of the World Health Organization (W
Research Unit (MORU)
in Bangkok, and comprises
research groups and National Malaria Control Programmes in each of the study - site countries, along with the London School of Hygiene and Tropical Medicine (LSHTM), the Liverpool School of Tropical Medicine (LSTM), the WorldWide Antimalarial Resistance Network (WWARN) and the Global Malaria Programme of the World Health Organization (W
research groups and National
Malaria Control Programmes
in each of the study - site countries, along with the London School of Hygiene and Tropical Medicine (LSHTM), the Liverpool School of Tropical Medicine (LSTM), the WorldWide Antimalarial Resistance Network (WWARN) and the Global
Malaria Programme of the World Health Organization (WHO GMP).
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Research Comments Off on
Malaria May Head For the Hills
by 2080
Just last month,
research by the Kenya National Bureau of Statistics showed that pneumonia has killed more Kenyans that
malaria in the past year, and that people who use kerosene, animal waste, charcoal and wood fuel for lighting and cooking — especially
in rural Kenya — are more likely to die from pneumonia [1].