«We've rationally designed something to target multiple pathways, which is contrary to the traditional
thinking in medicinal chemistry, where you have one target, one drug,» said University of Illinois chemistry professor Steven Zimmerman, who led the research with graduate students Lien Nguyen and Long Luu.
«All these are commonly
used in medicinal chemistry either as final drug compounds or intermediate compounds from which the final compounds are made,» Yu said.
Taken together, these data suggest that indole derivatives, although their IC50 values are in the micromolar range, represent functional leads for further development of novel CXCR4 antagonists
useful in medicinal chemistry programs.
Michel Detheux, iTeos» Chief Executive Officer added, «The progress of our adenosine A2A antagonist program demonstrates how we can rapidly apply our
expertise in medicinal chemistry, tumor immunology and translational medicine to advance candidates toward clinical development.»
SASTA board member Dr. Magid Abu Gharbia was honored with the Grand Hamdan International Award in Drug Discovery in recognition of Abou - Gharbia's outstanding contributions and pioneering
work in medicinal chemistry and drug discovery.
John L. Neumeyer, PhD, received his BS from Columbia University, and
PhD in medicinal chemistry from the University of Wisconsin, Madison.