Sentences with phrase «in mice lungs»

While the UC Riverside did not look at the toxicity of GO in their study, researchers at the Hersam group from Northwestern University did report in a paper published in the journal Nano Letters («Minimizing Oxidation and Stable Nanoscale Dispersion Improves the Biocompatibility of Graphene in the Lung») that GO was the most toxic form of graphene - based materials that were tested in mice lungs.

Through many painstaking experiments, she zeroed in on a signaling pathway called Wnt, known to be important in mouse lung development.

After LPS was added, the neutrophils in a mouse lung deficient in CD11b crawled about a third of the distance as the neutrophils in a normal mouse lung.

ON TRACK Neutrophils (red) crawl along the walls of capillaries in a mouse lung (tracks shown in blue).

The inhibition of Rac1 also led to cell death in mouse lungs cultured in the lab.

They make up only about 10,000 of the 10 million cells in a mouse lung.

E-cigarette smoke damages DNA and reduces repair activity in mouse lung, heart, and bladder as well as in human lung and bladder cells, reports a new study, published in PNAS.

Function, activity, and membrane targeting of cytosolic phospholipase A2ζ in mouse lung fibroblasts.

These images show the development of cancer (dark purple) in the mouse lung, initiated by lentiviral vector.

Not exact matches

«Indeed, in a second tumor model of metastatic breast cancer, we demonstrated that mice treated with the EphA2 - targeting paclitaxel conjugate presented nearly no lung metastases, while a large numbers of lesions were observed in both untreated mice and in mice treated with just paclitaxel.»

«We found that in young healthy mice the immune system overreacted to the influenza virus, which led to more inflammation, greater lung damage and increased mortality compared to healthy adults exposed to the virus,» says lead author Bria Coates, MD, Critical Care physician at Ann & Robert H. Lurie Children's Hospital of Chicago and Assistant Professor of Pediatrics at Northwestern University Feinberg School of Medicine.

Specifically, the researchers found that a peptide, called STAT6 - IP, when delivered to the lungs of neonatal mice at the time of first RSV exposure reduces the development of allergic - type lung inflammation and airway hyperresponsiveness («twitchy» airways) in mice when they are «re-challenged» with RSV as young adults.

The researchers confirmed this hypothesis by showing that if they blocked YAP1 they could inhibit stem cells from undergoing self - renewal, forming blood vessel - like structures, and reduce lung cancer cell growth in mice.

Despite the presumed virulence of the strain — experiments with mouse lungs showed it produces 1000 times more bacteria in infected cells than do standard varieties — Valway says the number of TB cases that developed were kept in line with other typical outbreaks, which «shows that doing good contact investigations is important and preventative therapy works.»

A team led by Antonia Sassmann - Schweda of the Max - Planck - Institute for Heart and Lung Research and colleagues generated mice lacking TAK1 specifically in adipocytes.

In the Cell study, Dr. Massagué, with Fellow Manuel Valiente, PhD, and other team members, found that in mouse models of breast and lung cancer — two tumor types that often spread to the brain — many cancer cells that enter the brain are killed by astrocyteIn the Cell study, Dr. Massagué, with Fellow Manuel Valiente, PhD, and other team members, found that in mouse models of breast and lung cancer — two tumor types that often spread to the brain — many cancer cells that enter the brain are killed by astrocytein mouse models of breast and lung cancer — two tumor types that often spread to the brain — many cancer cells that enter the brain are killed by astrocytes.

The new research investigated the effectiveness of MSC therapy in a mouse model of chronic inflammatory lung disease, which reflects some of the essential features of diseases such as COPD and cystic fibrosis.

The scientists tested the new compound using a mouse model of TB and found that substituting R207910 for one of three antibiotics in a treatment cocktail significantly reduced the time required to clear the animals» lungs of bacteria.

The scientists conclude that in mice «well - timed treatment with rIL - 27 improved lung injury and accelerated recovery without affecting viral clearance» and continue «these data demonstrate that IL - 27 has a unique role in controlling immunopathology without impacting on host defense, and might therefore represent a promising candidate for immunomodulatory therapy of viral pneumonia.»

In experiments conducted on human lung endothelial cells and in mice, the researchers showed that NS1 caused permeability of the endothelium, which lines the walls of blood and lymph vesselIn experiments conducted on human lung endothelial cells and in mice, the researchers showed that NS1 caused permeability of the endothelium, which lines the walls of blood and lymph vesselin mice, the researchers showed that NS1 caused permeability of the endothelium, which lines the walls of blood and lymph vessels.

Brueckner's group looked for gene defects in two strains of mice with situs inversus, a mutation in which the heart, lungs, and other organs are inverted, like a mirror image.

In this study, the researchers first exposed mice to house dust mites and found that production of pro-inflammatory IL - 17A and IL - 17F was triggered in the lungs of the animalIn this study, the researchers first exposed mice to house dust mites and found that production of pro-inflammatory IL - 17A and IL - 17F was triggered in the lungs of the animalin the lungs of the animals.

NIOSH immunotoxicologist Stacey Anderson has begun testing dicarbonyls, 4 - OPA in particular, to see if they provoke an immune reaction in mice or human lung cells.

Intrigued, Elias's group induced asthma attacks in their mice and then examined their lung tissue.

The findings, which are published in the journal Clinical Science, show that severe allergic lung inflammation was significantly reduced in the mice when the activity of the pro-inflammatory molecules interleukin (IL)-17 A and IL - 17F was prevented using specific antibodies.

Over this time, 30 per cent of the mice developed tumours around their body, including in their liver, colon, lungs and spleen.

The research team, Heller says, has already begun experiments to further explore the implications of these results, which include looking at differences in this pathway between cells taken from allergic and healthy individuals, and testing the efficacy of an inhalable drug that mimics the function of GRB1 and p70S6K to shut off the development of M2 macrophages in the lungs of mice.

Expression of CXCL16 was higher in the colon and lung tissue of GF mice than in normal mice, and blocking that expression reduced the numbers of iNKT cells and the amount of inflammation in those tissues.

The current study showed that a deficiency of both SRC - 1 and SRC - 2 inside the fetus» lungs drastically decreased the production of SP - A and PAF, causing a one - to two - day labor delay in mouse models, comparable to a three - to four - week labor delay in women.

Now, in a provocative study that raises unsettling questions about the widespread use of vitamin supplements, Swedish researchers have showed that relatively low doses of antioxidants spur the growth of early lung tumors in cancer - prone mice, perhaps by hindering a well - known tumor suppressor gene.

Compared to a control (left), epalrestat treatment (right) reduces the number of metastatic tumors (arrowheads) in the lungs of mice injected with human basal - like breast cancer cells.

Preliminary results from his latest mouse studies show that an herb used in traditional Chinese medicine supplies a microRNA that combats the flu virus in the lungs.

Their embryos had more profound defects than were seen in the Esrp1 - null mice, including craniofacial and forelimb defects, and the complete absence of lungs and salivary glands — two organs made up largely of epithelial cells.

Loss of either GSTO1 or RYR1, the researchers report, decreased the number of cancer stem cells in the primary tumor, blocked metastasis of cancer cells from the primary tumor to the lungs, decreased the duration of chemotherapy required to induce remission and increased the duration of time after chemotherapy was stopped that the mice remained tumor - free.

Dr. Shay's study closely monitored lung cancer development in mice after irradiation.

When given to infected mice, LCA60 dramatically reduced the amount of the MERS virus in the lungs within days.

However, Feske and his colleagues found that calcium signals also are required for the development of iTreg cells and that their numbers are strongly reduced in the lungs of the infected STIM1 - deficient mice.

«Physical forces are certainly a factor in getting the lung lining to be fully functional,» says Anne Bishop at Imperial College London, who has made alveolar cells from mouse stem cells using growth factors alone.

«This was associated with an unexpected accumulation of T - cells in the lungs of infected mice that lack STIM1.»

Specifically, they determined that the immune systems in genetically altered mice lacking the critically important calcium channel component STIM1 failed to control TB, leading to severe lung inflammation and premature death.

In the first series of tests, researchers found that luteolin inhibited the metastasis of triple - negative cancer in the lungs of affected micIn the first series of tests, researchers found that luteolin inhibited the metastasis of triple - negative cancer in the lungs of affected micin the lungs of affected mice.

«What we saw in mice lacking STIM1 — whose T - cells can not generate calcium signals — is that the number of mycobacteria in their lungs was dramatically increased, resulting in excessive inflammation,» says Stefan Feske, MD, an associate professor of pathology at NYU Langone and the study's senior author.

All of these findings were supplemented with several other experiments that were designed to learn how CHI3L1 interacts with other cells involved in the tissue repair response in both human and mouse lungs.

The preclinical study looked at the effect of DHA on lupus lesions in the lungs and kidneys of female mice that were already genetically predisposed to the disease.

A team from Cold Spring Harbor Laboratory in Long Island, N.Y., reports that it staved off full - blown metastasis in mice by preventing mini-tumors in the lungs from recruiting stem cells called endothelial progenitors, which assemble into blood vessels to nourish the malignancy.

Three days later, the scientists discovered that although the mice had cleared the bacteria from their livers, lungs, and spleens, the tumorous tissue in their colons was crawling with Salmonella.

The MRI imaging detected metastatic tumors, including micrometastases, in lung, liver, lymph node, adrenal gland, bone, and brains of the mice.

Next, the team used other mouse models in which part of the lung was removed and single cell culture to study the plasticity of cell types during lung regrowth.

By blocking these in lung endothelial cells, the researchers were able to slow lung tumor growth in mice and also reduce the spread of metastatic tumors.

Mice treated with the combination had almost 40,000 times fewer bacteria in their lungs.