Sentences with phrase «in mice models of diabetes»

The Joslin researchers then transplanted these modified human diabetic cells into wounds in mice models of diabetes that also had suppressed immune systems so that they didn't reject human cells.

«Natural killer cells help to drive inflammation, insulin resistance: Study in mouse models of diabetes identifies key immune mechanisms in abdominal fat.»

The two labs are now collaborating on further studies of the new enzymes — and the potential benefits of inhibiting them — in mouse models of diabetes, inflammation and autoimmune disease.

Not exact matches

In the new work, published June 10 in the journal Scientific Reports, Zhao, Reid and colleagues used a highly sensitive probe to measure electrical fields in the corneas of isolated eyes from three different lab mouse models with different types of diabetes: genetic, drug - induced and in mice fed a high - fat dieIn the new work, published June 10 in the journal Scientific Reports, Zhao, Reid and colleagues used a highly sensitive probe to measure electrical fields in the corneas of isolated eyes from three different lab mouse models with different types of diabetes: genetic, drug - induced and in mice fed a high - fat diein the journal Scientific Reports, Zhao, Reid and colleagues used a highly sensitive probe to measure electrical fields in the corneas of isolated eyes from three different lab mouse models with different types of diabetes: genetic, drug - induced and in mice fed a high - fat diein the corneas of isolated eyes from three different lab mouse models with different types of diabetes: genetic, drug - induced and in mice fed a high - fat diein mice fed a high - fat diet.

Scientists of the German Center for Diabetes Research (DZD) led by the German Institute of Human Nutrition (DIfE) have shown in a mouse model that the epigenetic * modification of the Igfbp2 ** gene observed in the young animal precedes a fatty liver in the adult animal later in life.

In addition to looking at mouse models of diabetes, the researchers also showed that exposure of human pancreatic islet cells — both from healthy donors and from patients with Type 1 diabetes — to fasting - mimicking diet in a dish stimulated insulin productioIn addition to looking at mouse models of diabetes, the researchers also showed that exposure of human pancreatic islet cells — both from healthy donors and from patients with Type 1 diabetes — to fasting - mimicking diet in a dish stimulated insulin productioin a dish stimulated insulin production.

The new study, using an experimental mouse model of diabetes, is published online in the journal PLOS One.

Most importantly, these cells protected mice from developing diabetes in a model of disease, having the critical ability to produce insulin in response to changes in glucose levels.

The patch, which feels like a mosquito bite when applied, has already proved effective in mouse models with type 1 diabetes for up to 9 hours, scientists report online before print in the Proceedings of the National Academy of Sciences.

Studies in mouse models suggest that BL - 9020 can inhibit beta cell death in the pancreas, thus preventing full maturation of Type 1 diabetes.

From the first day of transplantation, the cells produced insulin in response to glucose spikes in the mice's blood, alleviating the modeled diabetes.

Morgan Fullerton, lead author of the study, added: «Unlike the majority of studies using genetic mouse models, we haven't deleted an entire protein; we have only made a very minor genetic mutation, equivalent to what might be seen in humans, thus highlighting the very precise way metformin lowers blood sugar in Type 2 Diabetes»

«We think that for the first time, we have a mouse model of anorexia that closely resembles the conditions leading up to the disease in humans,» said study leader Lori Zeltser, PhD, associate professor of pathology & cell biology and a researcher in the Naomi Berrie Diabetes Center.

In a mouse model of type 1 diabetes, RGS1 affects the population of one type of T cell called a «T follicular helper cell» that is critical for B cells and antibody production, Dr. Kissler and his colleagues reported recently in Genes and ImmunitIn a mouse model of type 1 diabetes, RGS1 affects the population of one type of T cell called a «T follicular helper cell» that is critical for B cells and antibody production, Dr. Kissler and his colleagues reported recently in Genes and Immunitin Genes and Immunity.

Working in mice that were put on high - fat diets to model diabetes, «we demonstrated that obesity increases the expression of pro-inflammatory genes in abdominal fat, but not in other organs such as the liver or muscle, nor in subcutaneous fat,» says Jongsoon Lee, PhD, Assistant Investigator in Joslin's Section on Pathophysiology and Molecular Pharmacology and Assistant Professor of Medicine at Harvard Medical School.

Because PD - L1 / programmed cell death (PD - 1) deficiency accelerates development of diabetes in mouse models, Nasr et al. hypothesized that a defect in the PD - L1 / PD - 1 pathway may underpin the hyperglycemia observed in the nonobese diabetic (NOD) mouse model.

In the laboratory arm of the Joslin study, researchers studied a mouse model of human type 1 diabetes.

Similar findings were present in the cerebral cortex and other regions of the brain in these animals and also found in several other mouse models of diabetes.

Harmonising ontological descriptions of phenotype in mouse and human and improving links between mouse model data and human data, using diabetes and obesity as examples, will increase the relevance of data that is generated in mouse studies for clinical studies.

Scientists in the laboratory of C. Ronald Kahn, M.D., head of Joslin's Integrative Physiology and Metabolism research section, found that brain cholesterol synthesis, the only source of cholesterol for the brain, drops in several mouse models of diabetes.

Kissler and his research team are using a mouse model of type 1 diabetes to see what the genes do in a living animal.

The experimenters successfully tested the compound in the two mouse models «either treating right at the beginning of diabetes, or for reversal of toxic effects after three or four months of diabetes, which is even more difficult,» King says.

After colleagues at Sanofi provided an investigational compound that activates PKM2, the team showed that this compound could stop abnormalities in mouse podocytes both in cell culture and in two mouse models of diabetes.

In the Joslin study, scientists first examined gene expression in the hypothalamus of a mouse model of insulin - deficient (type 1) diabeteIn the Joslin study, scientists first examined gene expression in the hypothalamus of a mouse model of insulin - deficient (type 1) diabetein the hypothalamus of a mouse model of insulin - deficient (type 1) diabetes.

The metabolic exploration platform of ICS has a large expertise in phenotyping mouse model for diabetes, obesity and atherosclerosis.

The research team had already shown that the technique worked in mice but needed a more accurate model of human diabetes and so used dogs.

Studies using a mouse model of type 1 diabetes highlight a potential role for human adipose stem cells in treatment regimens and, further, they reveal a secreted factor which has important therapeutic relevance

As Kissler's lab began to examine whether pTregs play a role in diabetes, the scientists first looked for these cells in the non-obese diabetes (NOD) mouse model of type 1 diabetes.

The researchers followed up to identify markers of aging in these cells, using several mouse models — one with impaired glucose tolerance (a contributor to type 2 diabetes progression) and another that shows markers of rapid aging.

For example, in a mouse model of type 1 diabetes (T1D), it has been shown that microbiomes from males protect female mice from T1D development (Markle et al. 2013).

Using red blood cells modified to carry disease - specific antigens, a team of scientists from Whitehead Institute and Boston Children's Hospital have prevented and alleviated two autoimmune diseases — multiple sclerosis (MS) and type 1 diabetes — in early stage mouse models.

The center, founded in 2001, provides novel techniques for studying mouse models of diabetes and other metabolic disorders.

Marc Claret, head of the Neuronal Metabolism Control Group at IDIBAPS, adds that «our results also suggest pathological implications of this animal model, since a diet rich in fats makes these mice more susceptible to developing diabetes.»

In the mouse model of type 1 diabetes, susceptibility was also associated with variation in CTLA - 4 gene splicing with reduced production of a splice form encoding a molecule lacking the CD80 / CD86 ligand - binding domaiIn the mouse model of type 1 diabetes, susceptibility was also associated with variation in CTLA - 4 gene splicing with reduced production of a splice form encoding a molecule lacking the CD80 / CD86 ligand - binding domaiin CTLA - 4 gene splicing with reduced production of a splice form encoding a molecule lacking the CD80 / CD86 ligand - binding domain.

This proposed role for GM1 (and indirectly GD1a) provides a rationale for its potency in suppressing diabetes in NOD mice (10) and disease onset in other animal models of autoimmunity.

Autoimmune destruction of insulin - producing pancreatic β - cells is recognized as the key pathogenic feature of type 1 diabetes in patients and in the NOD mouse model (18).