Sentences with phrase «in migrating cells»

Protein Tyrosine Phosphatase - PEST and β8 Integrin Regulate Spatiotemporal Patterns of RhoGDI1 Activation in Migrating Cells.

Not exact matches

Based on animal models, including a primate model, it is hypothesized that the cells remain unharmed in the digestive tract of the infant then enter the bloodstream, migrate to different organs, and there provide active immunity.54

A few years ago, Cornelia Halin, professor at the Institute of Pharmaceutical Sciences, and her team observed that dendritic cells migrate in a zigzag pattern within lymphatic capillaries (see ETH Life article from 09.08.2012).

Cells migrate along the electric currents, closing the scratch wound in about 48 hours.

«Because this binding causes EphA2 internalization, we also sought to conjugate 123B9 with paclitaxel and thus direct the drug to migrating cancer cells,» said Pellecchia, who holds the Daniel Hays Chair in Cancer Research at UCR.

One research group investigating this possibility followed the activity of fetal microchimeric cells in a mother rat after the maternal heart was injured: they discovered that the fetal cells migrated to the maternal heart and differentiated into heart cells helping to repair the damage.

One of the key questions in biology is to identify how tissues are repaired after trauma and understand how stem cells migrate, proliferate, and differentiate to repair tissue damage.

Cells may migrate through the placenta between the mother and the fetus, taking up residence in many organs of the body including the lung, thyroid, muscle, liver, heart, kidney and skin.

And in a new study, Cornell University researchers report that tumor cells take advantage of already - cleared paths to migrate unimpeded.

In experiments on zebrafish, Freiburg researchers have demonstrated that the same proteins that lead to the formation of metastases in humans also cause the cells to migrate during embryonic developmenIn experiments on zebrafish, Freiburg researchers have demonstrated that the same proteins that lead to the formation of metastases in humans also cause the cells to migrate during embryonic developmenin humans also cause the cells to migrate during embryonic development.

In cancer cells, the protein networks that control the behavior are changed in such a way as to cause the cells to lose control and break away — a mutated skin cell, for instance, might then migrate into the bloodstreaIn cancer cells, the protein networks that control the behavior are changed in such a way as to cause the cells to lose control and break away — a mutated skin cell, for instance, might then migrate into the bloodstreain such a way as to cause the cells to lose control and break away — a mutated skin cell, for instance, might then migrate into the bloodstream.

The complexes then accumulate in distinctive, nonlysosomal MHC II + vesicles that appear to migrate to the cell surface.

«The potential advantage of stem cells,» says Eugene Redmond, a professor of neurosurgery at the Yale University School of Medicine and the lead author of that study, «is that they still have the potential to migrate and position themselves in appropriate places depending on what signals are there [in the brain].»

The data that the breast cancer cells spread more successfully in clumps are compelling, D'Souza - Schorey said, but no one yet knows whether cells from other types of cancer also need help to migrate.

During normal brain development in the first weeks of life, precursor cells in the SVZ in the piglets give birth to neurons that migrate primarily to the prefrontal cortex, the team reports today in Science Translational Medicine.

In newborn mammals, the SVZ is the biggest depot for the precursor cells that migrate to populate various brain regions, and differentiate into multiple cell types.

«Disturbances to these processes may cause neuronal stem cells to develop into different types of cells or may cause neurons to migrate to different locations in the brain, changing neuronal circuitry and potentially leading to behavioral disorders like schizophrenia.»

During the active disease stage of JIA, these cells expand, grow in number, re-circulate through inflamed areas of patients» body, and migrate to the connective tissue of patients» joints.

Those embryonic cells migrate in the embryo and contribute to tissues involved in the fight - or - flight response, facial development and coloring.

The brain harbors about 86 billion neurons, or nerve cells, that have to be born at the right time, migrate to the right place, and wire up in the right way if we are to survive and thrive.

In unpublished research, Cagan (now at the Wellcome Trust Sanger Institute in Hinxton, England) found that genes involved in helping neural crest cells migrate differed between the tame and wild animals (SN: 6/13/15, p. 11In unpublished research, Cagan (now at the Wellcome Trust Sanger Institute in Hinxton, England) found that genes involved in helping neural crest cells migrate differed between the tame and wild animals (SN: 6/13/15, p. 11in Hinxton, England) found that genes involved in helping neural crest cells migrate differed between the tame and wild animals (SN: 6/13/15, p. 11in helping neural crest cells migrate differed between the tame and wild animals (SN: 6/13/15, p. 11).

In mice with pancreatic tumors, Kalbasi and other members of the team found relatively high levels of inflammatory compounds including CCL2, the signaling molecule that activates CCR2 on monocytes and macrophages to make these cells migrate to tumors.

Although NRF2 has many benefits, loss of NRF2 regulation leads to high levels in certain cancer cells, such as some lung cancers, and it may help them migrate, Zhang says.

But recent research in mice suggested cancer cells migrate in groups (SN: 1/10/15, p. 9).

In their report published in Science Immunology they describe how expression of a specific molecule — complement C5a — is required to cause the immune cells called neutrophils to adhere to joint surfaces and migrate into the joint, a process known to set off the inflammatory cascadIn their report published in Science Immunology they describe how expression of a specific molecule — complement C5a — is required to cause the immune cells called neutrophils to adhere to joint surfaces and migrate into the joint, a process known to set off the inflammatory cascadin Science Immunology they describe how expression of a specific molecule — complement C5a — is required to cause the immune cells called neutrophils to adhere to joint surfaces and migrate into the joint, a process known to set off the inflammatory cascade.

Intriguingly, all seven play a role in cell division, the process by which immature neurons multiply in the fetal brain, before migrating to their final location.

Adding a drug that blocked the calcium wave prevented microglia from migrating to the injury site, the team reports today in Developmental Cell.

«We watch the bromine ions migrate within minutes and see that the resulting bromine - rich areas have the potential to become better solar cells while the performance is degraded in bromine - poor areas,» Fenning said.

«In order to simulate the oil recovery process we divide the reservoir up into small segments or cells and describe how the oil migrates from cell to cell.

The research team found that a key downstream effect of depleting the protein was that particular cells failed to migrate to the heart, where they would usually have played key roles in developing heart structures.

They might be put to use right away to track cultures of immune cells as they migrate in response to chemical stimuli.

Last year, the same researchers showed that the trigger came from cells in a structure in the embryonic brain called the floor plate, which dopamine cells brush past while migrating to their eventual home in a part of the brain called the substantia nigra.

Working with human breast cancer cells and mouse models of breast cancer, scientists identified a new protein that plays a key role in reprogramming cancer cells to migrate and invade other organs.

T lymphocytes, immune cells which circulate in the blood, must migrate across the walls of blood vessels in order to reach inflamed tissue.

A 2010 study in Stem Cells and Development showed that fetal cells can migrate to the brain of a mother mouse and mature into neurons, Nelson Cells and Development showed that fetal cells can migrate to the brain of a mother mouse and mature into neurons, Nelson cells can migrate to the brain of a mother mouse and mature into neurons, Nelson says.

The team of medical and engineering researchers at The Ohio State University previously determined that modifying a single gene to reduce this protein's level in breast cancer cells lowered the cells» ability to migrate away from the tumor site.

In a study published online in Circulation Research late last year, Chaudhry and colleagues found that fetal cells in mice migrated to the mother's heart, differentiated into functioning cardiac cells, and accelerated repair to damaged heart tissuIn a study published online in Circulation Research late last year, Chaudhry and colleagues found that fetal cells in mice migrated to the mother's heart, differentiated into functioning cardiac cells, and accelerated repair to damaged heart tissuin Circulation Research late last year, Chaudhry and colleagues found that fetal cells in mice migrated to the mother's heart, differentiated into functioning cardiac cells, and accelerated repair to damaged heart tissuin mice migrated to the mother's heart, differentiated into functioning cardiac cells, and accelerated repair to damaged heart tissue.

Finally, says Evrony, the findings provide a proof - of - principle for a systematic way of studying how brain cells disperse and migrate during development, «something that has not been possible to do before in humans,» he says.

Understanding how cancer cells are able to metastasize — migrate from the primary tumor to distant sites in the body — and developing therapies to inhibit this process are the focus of many laboratories around the country.

Many tumors spread: Single cancer cells migrate with blood flow through the body before they settle in new tissue.

It tended to be sequestered in the nucleus but migrated out into the cell's gelatinous exurbs, or cytoplasm, when the cell was about to divide.

In contrast to other cell - movement systems in which cells migrate along fibers or reorganize the extracellular matrix, the «hand - over-hand» pulling causes the shortening and bending of platelet - attached fiberIn contrast to other cell - movement systems in which cells migrate along fibers or reorganize the extracellular matrix, the «hand - over-hand» pulling causes the shortening and bending of platelet - attached fiberin which cells migrate along fibers or reorganize the extracellular matrix, the «hand - over-hand» pulling causes the shortening and bending of platelet - attached fibers.

The cells originate outside the central nervous system in the ectoderm of the body wall and appear to migrate to their final locations within the central nervous system by crawling along strands of connective tissue.

When Gillian Bates at Guy's Hospital, London and Stephen Davies at University College in London and their colleagues examined the brains of transgenic mice endowed with a DNA encoding 150 of these glutamine repeats, they found that the protein started out, at birth, in the cytoplasm of the animals» brain cells and then gradually migrated to cell nuclei and clumped there.

TB is known for trying to block activation of T cells by infected dendritic cells, two kinds of which are primarily involved in fighting infection: dendritic cells that migrate from the lungs to the lymph nodes, and those that already reside in the lymph nodes.

Previous research has demonstrated that Akt1 is at least partly responsible for the development of myofibroblasts, cells that migrate to the sites of injury to aid in wound healing.

Research suggests that very scarce chemical cues can trigger physical changes in the cell, including remodeling the plasma membrane and recruiting cytoskeletal machinery, to transform the dichty from a fat, happy cell to an elongated cell with a distinct front and rear end, ready to migrate.

It is still not entirely clear whether the cancer cells migrate directly through the resulting gap in the vascular wall or whether there is an indirect effect: «We have evidence that many more molecules are released when the vascular wall cell dies and that they render the surrounding area more permeable to cancer cells,» says Offermanns.

Lee, Daugharthy and their colleagues then tested the method to detect the genes skin cells turn on as they multiply and migrate to heal a simulated wound in a petri dish.

Genetically modified «hunter» T cells successfully migrated to and penetrated a deadly type of brain tumor known as glioblastoma (GBM) in a clinical trial of the new therapy, but the cells triggered an immunosuppressive tumor microenvironment and faced a complex mutational landscape that will need to be overcome to better treat this aggressive cancer, Penn Medicine researchers report in a new study this week in Science Translational Medicine.