Sentences with phrase «in model membranes»

Alf Honigmann, Sina Sadeghi, Jan Keller, Stefan W. Hell, Christian Eggeling, Richard Vink A lipid bound actin meshwork organizes liquid phase separation in model membranes.

Lateral sorting in model membranes by cholesterol - mediated hydrophobic matching.

Sorting in model membranes by cholesterol - mediated hydrophobic matching.

Selective inhibition of the Nav1.7 pain channel; Crystal structure of a Nav1.7 - antagonist complex viewed in a model membrane.

Not exact matches

In the model, two «sensor» neurons from different points on the basilar membrane and representing different frequencies send signals to a third «interneuron» that combines the two signals into one.

Here, we present experiments using a reconstituted fusion system that suggest a simple model in which the complexin accessory helix forms an alternative four - helix bundle with the target - SNARE near the membrane, preventing the vesicle - SNARE from completing its zippering.

The unusual dimer of the ZIKV protease: inhibitor complex seen in the crystal may provide a model for assemblies formed at high local concentrations of protease at the endoplasmatic reticulum membrane, the site of polyprotein processing.

Interactions of these proteins with the outer membrane in vivo and in vitro are well known, allowing for direct comparisons with the synthetic model.

In the final step in bacterial cell division, constriction of the so - called Z - ring, an annular structure that forms on the plasma membrane near the midpoint of the cell, gives rise to the two daughter cells: A research team led by Erwin Frey, who holds the Chair of Statistical and Biological Physics at LMU, has now used mathematical modelling to understand the mechanism that drives formation of the Z - ring, and in so doing have uncovered a novel class of pattern - forming mechanism in biological systemIn the final step in bacterial cell division, constriction of the so - called Z - ring, an annular structure that forms on the plasma membrane near the midpoint of the cell, gives rise to the two daughter cells: A research team led by Erwin Frey, who holds the Chair of Statistical and Biological Physics at LMU, has now used mathematical modelling to understand the mechanism that drives formation of the Z - ring, and in so doing have uncovered a novel class of pattern - forming mechanism in biological systemin bacterial cell division, constriction of the so - called Z - ring, an annular structure that forms on the plasma membrane near the midpoint of the cell, gives rise to the two daughter cells: A research team led by Erwin Frey, who holds the Chair of Statistical and Biological Physics at LMU, has now used mathematical modelling to understand the mechanism that drives formation of the Z - ring, and in so doing have uncovered a novel class of pattern - forming mechanism in biological systemin so doing have uncovered a novel class of pattern - forming mechanism in biological systemin biological systems.

«For conventional mathematical models of this process pattern formation of MinE and MinD on the membrane can only work if the concentration of MinE is less than that of MinD,» says Jonas Denk, a PhD student in Frey's team and joint first author of the new paper.

Prof. De Meyts assures that «Prof. Maruyama makes a convincing case that this [dimerization] model is incorrect, and that in fact, numerous cell membrane receptors are pre-dimerized in the membrane and are activated allosterically by ligand binding.»

The «rotation model» Ligand binding to the extracellular part of the receptor induces rotation of the receptor's transmembrane region inside the cell membrane, and in doing so, regulates its activity inside the cell.

«Guided by observations that show that the membrane thickness varies from pole to pole, we constructed a mathematical model that considers the egg to be a pressurized elastic shell that grows and showed that we can capture the entire range of egg shapes observed in nature,» said Mahadevan.

To examine the role of soluble antibodies in the accumulation of MDSCs, they included an additional model of CLL in which B cells can only produce membrane - bound antigen receptors but not soluble antibodies.

Concomitantly, the NpSRII / NpHtrII complex will serve as model system for development of new site - directed spin labeling EPR methods to elucidate the structure and conformational dynamics of membrane proteins and protein clusters in vitro and in vivo.

Discovery of novel disease - specific and membrane - associated candidate markers in a mouse model of multiple sclerosis.

Our technological expertise ranges from the most fundamental approaches to study membrane transport in lymphocytes and dendritic cells (subcellular compartmentalization, intravital microscopy, phagosomal functions), the systematic analysis of gene expression and it regulation (RNAseq, Chip Seq, proteomics) and physiological and pathological immune responses (mouse models for cancer immunity, immunomodulation / vaccination, human clinical studies in cancer).

(Invited) Multiscale Modeling of Transport Phenomena in Ion - Conducting Membranes and Aqueous CO2 Reduction Cells A. Z. Weber, A. R. Crothers, M. Singh, C. J. Radke, and A. T. Bell

The computer models that the winners have developed are of great importance for research in membrane proteins at Stockholm University and SciLifeLab.

Using whole - cell path clamp, both dSPNs and iSPNs from Q175 6 - month old mice showed elevated membrane resistance and reduced rheobase current, consistent with previous reports of SPN hyperexcitability in mouse models of HD.

Exploring the effects of sterols in model lipid membranes using single - molecule orientations.

The Evaluation of a Biphasic Osteochondral Implant Coupled with an Electrospun Membrane in a Large Animal Model.

In particular we are interested to unravel the mechanisms that ensure the maintenance of the apical membrane when exposed to physical stress, e. g. during morphogenesis of epithelial tissues, or when exposed to light stress in photoreceptor cells, using Drosophila and zebrafish as model organismIn particular we are interested to unravel the mechanisms that ensure the maintenance of the apical membrane when exposed to physical stress, e. g. during morphogenesis of epithelial tissues, or when exposed to light stress in photoreceptor cells, using Drosophila and zebrafish as model organismin photoreceptor cells, using Drosophila and zebrafish as model organisms.

This gives a high level of flexibility for the search algorithm as well, because both general (i.e. free rotation and translation) and more specific moves (i.e. adding a new structure element to an existing model in the membrane plane) are allowed and biased by probability.

Previous work has given insights into the mechanistic pathways leading to small molecule sequestration in membrane - free coacervate protocells; successfully demonstrated the use of liquid - liquid phase separated micro compartments for protein expression using cell free expression systems; exploited microfluidics for the high throughput formation of stable, monodisperse microdroplets; and integrated two contrasting modes of protocell construction to produce a novel hybrid model based on fatty acid membrane - bound coacervate micro-droplets.

Spectroscopy & Application of Lasers, Zare / Moerner / +, 6 - 1 Nuclear Hormone Signaling, Chambon / Evans / Jensen, 6 - 1 Bioinorganic Chemistry, Gray / Lippard / Holm / — , 8 - 1 The Field (everything not listed), 10 - 1 Techniques in DNA Synthesis, Caruthers / Hood / +, 10 - 1 Electrochemistry / Electron Transfer, Bard / Hush / Gray / — , 19 - 1 Instrumentation / Techniques in Genomics, Venter / +, 19 - 1 Biological Membrane Vesicles, Rothman / Schekman / +, 19 - 1 Molecular Studies of Gene Recognition, Ptashne, 19 - 1 Organic Electronics, Tang / +, 39 - 1 Polymer Science, Matyjaszewski / Langer / + / — 69 - 1 Solar Cells, Grätzel / +, 74 - 1 Mechanistic Enzymology, Walsh / Stubbe / Koshland / + / — , 74 - 1 Combinatorial Chemistry / DOS, Schreiber / +, 99 - 1 Pigments of Life, Battersby / +, 99 - 1 Development of the Birth Control Pill, Djerassi, 99 - 1 Molecular Modeling and Assorted Applications, Karplus / Houk / Schleyer / Miller / + / — , 99 - 1 Applications of NMR Spectroscopy, Pines / Roberts / McConnell / + / — , 99 - 1 Development of Chemical Biology, Schultz / Schreiber / +, 99 - 1 Self - Assembly, Whitesides / Nuzzo / Stang / — , 149 - 1 Small Regulatory RNA, Ambros / Baulcombe / Ruvkun, 149 - 1 Nanotechnology, Lieber / Whitesides / Alivisatos / Mirkin / Seeman / + / — , 149 - 1 Eukaryotic RNA Polymerases, Roeder, 149 - 1 Contributions to Theoretical Physical Chemistry, Rice / +, 149 - 1 Mechanical Bonds and Applications, Sauvage / Stoddart / +, 149 - 1 Bio - & Organo - catalysis, List / Lerner / Barbas / + / — , 149 - 1 Organic Synthesis, Evans / Danishefsky / Nicolaou / Ley / Trost / Stork / Wender / Kishi / + / — , 199 - 1 Leptin, Coleman / Friedman / Leong, 199 - 1 Fluorocarbons, DuPont / Curran / — , 199 - 1 Understanding of Organic Stereochemistry, Mislow, 199 - 1 Tissue Engineering, Langer / +, 199 - 1 Contributions to Bioorganic Chemistry, Breslow / Eschenmoser / +, 199 - 1 Dendrimers, Frechet / Tomalia / +, 399 - 1 Zeolites, Flanigan, 399 - 1 Molecular Recognition, Dervan / +, 399 - 1 Molecular Machines, Stoddart / Tour / + / — , 399 - 1 Astrochemistry, Oka, 999 - 1

Here the authors, using an ex-vivo model, show that cancer - associated fibroblasts facilitate colon cancer cells invasion in a matrix metalloproteinase - independent manner, likely by pulling and stretching the basement membrane to form gaps.

Dmitry: as the paper itself notes, the most likely mechanism for the ability of hydroxypropyl - β - cyclodextrin to lower Aβ burden in the mouse model is AD finding is by normalizing membrane cholesterol content and reducing the appearance of abnormal cathepsin D - positive lysosomes, leading to reduced beta - secretase cleavage of APP and an upregulation of genes involved in cholesterol trafficking and Aβ clearance.

Kaphzan, H., Buffington, S.A., Jung, J.I., Rasband, M.N., and Klann, E. (2011) Alterations in intrinsic membrane properties and the axon initial segment in a mouse model of Angelman syndrome.

In particular, an experimental study on the permeability of prebiotic vesicle membranes composed of binary lipid mixtures allows us to construct a semi-empirical model where protocells are able to reproduce and undergo an evolutionary process based on their coupling with an internal chemistry that supports lipid synthesis.

Scientists have developed a model of the outer membrane of the bacteria E.coli providing a brand new tool for developing new antibiotics and other drugs in the fight against infections.

Aside from antioxidant mechanisms (stabilizing free radicals that would normally damage lipid membranes and microcirculation), vitamin C can help normalize pain - inhibiting pathways involving dopamine, NMDA, and other neurotransmitters, and has shown promise for a variety of pain conditions in animal models.

For example, KBs were recently reported to act as neuroprotective agents by raising ATP levels and reducing the production of reactive oxygen species in neurological tissues, 80 together with increased mitochondrial biogenesis, which may help to enhance the regulation of synaptic function.80 Moreover, the increased synthesis of polyunsaturated fatty acids stimulated by a KD may have a role in the regulation of neuronal membrane excitability: it has been demonstrated, for example, that polyunsaturated fatty acids modulate the excitability of neurons by blocking voltage-gated sodium channels.81 Another possibility is that by reducing glucose metabolism, ketogenic diets may activate anticonvulsant mechanisms, as has been reported in a rat model.82 In addition, caloric restriction per se has been suggested to exert neuroprotective effects, including improved mitochondrial function, decreased oxidative stress and apoptosis, and inhibition of proinflammatory mediators, such as the cytokines tumour necrosis factor - α and interleukins.83 Although promising data have been collected (see below), at the present time the real clinical benefits of ketogenic diets in most neurological diseases remain largely speculative and uncertain, with the significant exception of its use in the treatment of convulsion diseasein neurological tissues, 80 together with increased mitochondrial biogenesis, which may help to enhance the regulation of synaptic function.80 Moreover, the increased synthesis of polyunsaturated fatty acids stimulated by a KD may have a role in the regulation of neuronal membrane excitability: it has been demonstrated, for example, that polyunsaturated fatty acids modulate the excitability of neurons by blocking voltage-gated sodium channels.81 Another possibility is that by reducing glucose metabolism, ketogenic diets may activate anticonvulsant mechanisms, as has been reported in a rat model.82 In addition, caloric restriction per se has been suggested to exert neuroprotective effects, including improved mitochondrial function, decreased oxidative stress and apoptosis, and inhibition of proinflammatory mediators, such as the cytokines tumour necrosis factor - α and interleukins.83 Although promising data have been collected (see below), at the present time the real clinical benefits of ketogenic diets in most neurological diseases remain largely speculative and uncertain, with the significant exception of its use in the treatment of convulsion diseasein the regulation of neuronal membrane excitability: it has been demonstrated, for example, that polyunsaturated fatty acids modulate the excitability of neurons by blocking voltage-gated sodium channels.81 Another possibility is that by reducing glucose metabolism, ketogenic diets may activate anticonvulsant mechanisms, as has been reported in a rat model.82 In addition, caloric restriction per se has been suggested to exert neuroprotective effects, including improved mitochondrial function, decreased oxidative stress and apoptosis, and inhibition of proinflammatory mediators, such as the cytokines tumour necrosis factor - α and interleukins.83 Although promising data have been collected (see below), at the present time the real clinical benefits of ketogenic diets in most neurological diseases remain largely speculative and uncertain, with the significant exception of its use in the treatment of convulsion diseasein a rat model.82 In addition, caloric restriction per se has been suggested to exert neuroprotective effects, including improved mitochondrial function, decreased oxidative stress and apoptosis, and inhibition of proinflammatory mediators, such as the cytokines tumour necrosis factor - α and interleukins.83 Although promising data have been collected (see below), at the present time the real clinical benefits of ketogenic diets in most neurological diseases remain largely speculative and uncertain, with the significant exception of its use in the treatment of convulsion diseaseIn addition, caloric restriction per se has been suggested to exert neuroprotective effects, including improved mitochondrial function, decreased oxidative stress and apoptosis, and inhibition of proinflammatory mediators, such as the cytokines tumour necrosis factor - α and interleukins.83 Although promising data have been collected (see below), at the present time the real clinical benefits of ketogenic diets in most neurological diseases remain largely speculative and uncertain, with the significant exception of its use in the treatment of convulsion diseasein most neurological diseases remain largely speculative and uncertain, with the significant exception of its use in the treatment of convulsion diseasein the treatment of convulsion diseases.

A rotary switch in the rear console of the Maybach 62 models gives the rear passengers complete control over the illumination of the membrane and strength of the ambient lighting.

When an alternating current is applied to it, the crystals in the plastic membrane are arranged in such a way that the glass becomes transparent and allows daylight into the rear of the Maybach 62 models over its entire area.

Even if a working model is on the market in 6 months then think of all the oil that will be needed to make the polymer membranes.

About Blog Oxford Protein Informatics Group is a research group in the Department of Statistics at the University of Oxford focusing on aspects of protein modelling, homology modelling, membrane proteins, sequence alignment, antibodies, and drug discovery.