Sentences with phrase «in model organisms»

This finding represents one of the first examples of a genome - wide significant genetic factor to be identified for binge eating in model organisms or humans.

In the last few years, several studies have shown that gene therapy, especially if applied early, can stop or reverse some forms of congenital blindness in model organisms.

Until now, scientists wishing to delete a gene in a model organism like a mouse did it by clipping out stretches of DNA encoding entire genes or very big chunks of them from the animal's genome.

Finally, the authors addressed two major challenges for any study that generates large data - sets of individual genes and proteins in model organisms like yeast: How to assemble the data into coherent maps?

Our lab investigates the mechanisms by which this complex and similar groups of proteins organize DNA and regulate transcription in human cells and tissues, as well as in the model organism of Drosophila melanogaster.

In 1997, when few genome sequences were available, Hieter helped create XREFdb, a public database that linked the functional annotations of genes studied in model organisms with the phenotypic annotations on the human and mouse genetic maps.

We aim to address this question using molecular biology tools, microscopy and genetics in the model organism C. elegansand hope to extend our knowledge by studying other nematodes, namely Caenorhabditis briggsae and Pristionchus pacific us.

The obvious key to living longer is to eat less, and significantly cutting calories has been shown to lengthen life span substantially in model organisms such as worms and mice.

Now we are embarked on experiments that will show improvements in both healthspan and lifespan in model organisms from mice to primates.

Laux's team studied the stem cells in the model organism of the Arabidopsis plant, or rock cress, which is part of the Brassicaceae family of plants, including mustard and cabbage.

An underappreciated implication of these results is that classical genetic methods we use to study biological traits in model organisms are insufficient to understand the molecular mechanisms controlling biological traits.

Her interest was piqued: Upon graduating in 1999 she joined the lab of Ding Xue at the University of Colorado, Boulder, to study how cell death is regulated in the model organism Caenorhabditis elegans.

In the next phase of the study, we will examine and categorize the functions of the genes that we identified — not only in model organisms, but also in agriculturally and economically important crops such as corn.»

Schizophrenia researcher Daniel Weinberger of the National Institute of Mental Health in Bethesda agrees that the paper adds to evidence that epistasis — which has been shown in model organisms such as yeast but difficult to prove in humans — is «robust and ubiquitous.»

Changes to a single gene in a model organism in plant biology, Arabidopsis thaliana, have been found to promote faster - growing and larger root systems — an application that could help researchers engineer bigger, better crops capable of sequestering more atmospheric carbon.

Follow - up studies have revealed hundreds of modified proteins in the model organism Bacillus subtilis.

The team also uncovered a unique class of gustatory receptor neurons (GRNs) necessary for calcium taste in these model organisms.

«Let's say we want to find a new antidiabetic compound,» explains Geoffrey Duyk, CEO of Exelixis, a California - based company that specializes in model organisms.

Although protein is highly conserved in evolution, previous mtEF4 gene knockouts in some model organisms did not show significant phenotypic change.

«Using the anti-cancer drug and a replication inhibitor, hydroxyurea, in the model organism Saccharomyces cerevisiae, we observed that double strand breaks preferentially occurred at hydroxyurea - induced genes,» said Feng.

Using a novel method they developed to map chromosome breaks in a model organism, the budding yeast, Wenyi Feng, Ph.D., of Upstate Medical University and her colleagues have discovered new information as to how and where chromosome fragile sites can occur in human DNA.

The researchers analysed neurogenesis at the molecular level in the model organism Nematostella vectensis.

Vijg argues that findings in model organisms aren't necessarily applicable to humans because these animals are bred to have certain traits.

The zebrafish is a good choice because of its similarity to humans as a vertebrate, its transparency as an embryo, and the powerful genetic tools available in this model organism.

Her doctoral thesis involved studying the role of GABAB - like GPCRs in model organism, Dictyostelium discoideum.

Research at EMBL is focussing on a central strategic goal: the fundamental understanding of basic biological processes in model organisms.

Subsequent validation experiments in model organisms will test if and how the elements pinpointed by the computational approaches are involved in changing molecular and morphological phenotypes.

We will mine and exploit information from studies and screens in model organisms, but our primary focus is on the paradigmatic mammalian stem cell systems - haematopoiesis and epithelia in vivo, and embryonic and neural stem cells in vitro.

Molecular genetics and bioinformatics.Analysis of inositol metabolism in the model organism Drosophila melanogaster.

Dietary restriction and the modulation of nutrient - sensing pathways are robust and reproducible interventions that extend life / healthspan in model organisms.

One award funds genetics research in human and non-human mammals, and another award funds genetics research in model organisms.

Lisa Krug defended her Ph.D. thesis, in which she studied the molecular basis of ALS in a model organism: the fruit fly Drosophila melanogaster...

Now in her final year at Oxford, Mehera spends most of her time in the lab studying DNA repair in the model organism Dictyostelium, a slime mold with proteins that may inform human cancer research.

The goal of the research in the McGrath laboratory is to develop new approaches to generate and study multigenic trait changes in model organisms.

This makes them ideal to predict gene function, by transferring known functional annotations from orthologs in model organisms.

We have taken a large - scale, multi-organism approach to address the question of which genes and pathways identified in model organisms are most likely to be relevant for human aging.

Moreover, the replication of these alleles in model organisms allows the experimental study of their activity in vivo, and testing of therapeutic strategies to mitigate their pathophysiological effects.

The organizers of the project, called GP - write (for work in model organisms and plants) or sometimes HGP - write (for work in human cell lines), envision it as a successor to the Human Genome Project (retroactively termed HGP - read), which 25 years ago promoted rapid advances in DNA sequencing technology.

Dr. Andrew Hill: They do extend lifespan in model organisms but they do it at the cost of either mobility or reproduction, right?

Alyssa's previous scientific endeavors focused on embryonic cell biology in model organisms and development of novel image analysis techniques.

They use a wide range of tools and systems, including genetics in model organisms, cell culture, biochemistry, proteomics, and genomics.