Sentences with phrase «in model validation»

One of the central tests in model validation is that the climatology produced by the models does match observations — for example, in the linked information, they talked about realistic El Nino cycles, monsoons and so forth.

Experts in model validation say that the climate models frequently cited in the IPCC report are little if any validated.

The ice core data are used in model validation.

Not exact matches

But it's also interesting as validation of a model that's becoming increasingly popular: Companies that are private only in name.

Last week, Musk said cars currently in production — which include the Model S, Model X, and future Model 3 — will be built with new hardware to allow them to be fully driverless, pending further software validation and regulatory approval.

The results were a validation of Jeff Bezos's customer - centric philosophy and the Amazon Prime membership model, sending the shares up the most in almost a year Friday morning.

A range of factors have driven this shift, including a sharp reduction in the cost to advance technology companies to proof of concept and business model validation — aided by declining infrastructure expenses, the rise of cloud - based software and service providers, and «pay as you grow» cost structures.

When medical modeling and simulation was a new field, it required clinical validations and evaluation to determine its effectiveness in a training environment.

In the customer development process at the end of customer validation the business model is verified.

Essentially startups need to «instrument» all parts of their business model to measure how well their hypotheses in Customer Discovery and Validation are faring in the real world.

Highland Capital's commitment to acquire the Series A preferred stock, combined with a sizeable position they have acquired in the common stock, has provided further institutional validation of JCAP's business model.

The «customer validation» process described by Steven Blank in his book, The Four Steps to the Epiphany, offers startups a way of developing the insights required to design your business model using Osterwalder's Business Model Camodel using Osterwalder's Business Model CaModel Canvas.

Several lenders and service providers in connection with the design and validation of lending and consumer scoring models.

See Ricoeur's discussion of the problem of validation vis a vis Hirsch in «The Model of the Text», op.cit.,158 - 162.

Based on their findings, they urge that «mosquito saliva and enhancing antibodies thus need to be considered when developing vaccines and drugs against dengue,» and specifically suggest that «animal models of dengue and pre-clinical validation of dengue vaccine candidates should be evaluated in the combined presence of mosquito saliva and enhancing antibodies.»

«These data I think [are] the validation, at least in animal models, that this messenger RNA therapy could work.»

From accelerating the identification and validation of novel therapeutic targets, to creating better animal models of human diseases in a shorter time frame, to reducing the number of failed products, Crispr looks set to shave millions off R&D costs and boost drug discovery, she says.

Historian of science Naomi Oreskes, now at Harvard, first came to my attention 20 years ago, when she and two co-authors argued in Science that «verification and validation of numerical models of natural systems is impossible.»

Any results that are reported to constitute a blinded, independent validation of a statistical model (or mathematical classifier or predictor) must be accompanied by a detailed explanation that includes: 1) specification of the exact «locked down» form of the model, including all data processing steps, algorithm for calculating the model output, and any cutpoints that might be applied to the model output for final classification, 2) date on which the model or predictor was fully locked down in exactly the form described, 3) name of the individual (s) who maintained the blinded data and oversaw the evaluation (e.g., honest broker), 4) statement of assurance that no modifications, additions, or exclusion were made to the validation data set from the point at which the model was locked down and that neither the validation data nor any subset of it had ever been used to assess or refine the model being tested

Diamond is also quick to point out that while the current study shows that COXEN could have been used to predict the most useful drug in many of these cases of advanced ovarian cancer, the actual use of the model will be possible only after validation with a prospective clinical trial.

They found that genes activated in the mouse model closely mirrored genes known to be activated in infected humans, providing a level of validation of the model.

The researchers also tested their prediction models on the validation set, and this resulted in ROC (receiver operating characteristic) plot points with an AUC (area under the curve) of 91.6 percent for general responsiveness, 89.7 percent for TNFi response and 85.7 percent for rituximab response.

The specific goal of releasing space - weather data from national - security assets such as GPS satellites is to enable broad scientific community engagement in enhancing space - weather model validation and improvements in space - weather forecasting and situational awareness.

«Once the in - vitro validation has been done, the efficacy of these compounds will be tested in pig and mouse models.

«In this manner, we'll help propel the community to develop microstructure - sensitive materials models and provide the validation needed to push materials to the next level of performance.»

IDMIT will contribute 1) To the development and validation of assays based on flow cytometry and mass cytometry for the evaluation of immune responses in humans and animal models; these tools will be particularly relevant for the identification of signatures of vaccine efficacy; 2) To the animal model platform, in particularly by providing access to NHP models and to new technologies for in vivo imaging infections and host responses; 3) To networking activities, in particular by organising a workshop on in vivo imaging.

The Genetic Engineering and Model Validation department is in charge of the generation of customized and ready - to - use genetically modified mouse.

In addition, the E3SM project benefits from - DOE programmatic collaborations including the Exascale Computing Project (ECP) and programs in Scientific Discovery Through Advanced Computing (SciDAC), Climate Model Development and Validation (CMDV), Atmospheric Radiation Measurement (ARM), Program for Climate Model Diagnosis and Intercomparison (PCMDI), International Land Model Benchmarking Project (iLAMB), Community Earth System Model Community Earth System Model (CESM) and Next Generation Ecosystem Experiments (NGEE) for the Arctic and the TropicIn addition, the E3SM project benefits from - DOE programmatic collaborations including the Exascale Computing Project (ECP) and programs in Scientific Discovery Through Advanced Computing (SciDAC), Climate Model Development and Validation (CMDV), Atmospheric Radiation Measurement (ARM), Program for Climate Model Diagnosis and Intercomparison (PCMDI), International Land Model Benchmarking Project (iLAMB), Community Earth System Model Community Earth System Model (CESM) and Next Generation Ecosystem Experiments (NGEE) for the Arctic and the Tropicin Scientific Discovery Through Advanced Computing (SciDAC), Climate Model Development and Validation (CMDV), Atmospheric Radiation Measurement (ARM), Program for Climate Model Diagnosis and Intercomparison (PCMDI), International Land Model Benchmarking Project (iLAMB), Community Earth System Model Community Earth System Model (CESM) and Next Generation Ecosystem Experiments (NGEE) for the Arctic and the Tropics.

Our goal in using this multifaceted model was two-fold 1) to confirm and further characterize the distinct behavioral traits in animals most susceptible to social stress after going through the 10 - day social defeat paradigm compared to undefeated control animals; 2) to provide pharmacological validation for this model using standard antidepressant medications such as fluoxetine and imipramine.

Position Description: The University of Vigo offers a Research Position in Vigo (Spain) to work with the Laboratory of Remote Sensing and GIS on the H2020 research project CoastObs in validation of Sentinel 3 data in order to provide information about the relationship between environmental conditions in HABs blooms and develop of local CASE 2 chl - a models.

«This is the first biological validation of a computational model developed in the early 1980s that suggested that two such forces would be necessary to guide axons as they establish the connections that relay spatial information from one part of the nervous system to another,» said study author Yimin Zou, PhD, assistant professor of neurobiology at the University of Chicago.

For a given tissue, we perform 3 - repeat -5-fold cross validation with the samples corresponding to the individuals of the training block in order to select the best model, and we generate the predictions over the unseen test set using this model.

The ICS is a large - scale facility open to the community that ensures the generation of mouse models à la carte, the validation of genetic models, the expansion and preservation and distribution of models with the housing department, and offers in its phenotyping department a series of standardized functional analysis of mouse models that can be performed in a comprehensive pipeline or on demand, as well as for more specialized studies, that cover the major functions and key physiological systems.

Once each tissue model is fitted on the training set with 3 - repeat -5-fold cross validation, we calculate the p - value of the F - test (Supplementary Fig. 28), R2 and slope (not shown) for the regression of the predicted tissue PMI in the test set versus the real tissue PMI.

Subsequent validation experiments in model organisms will test if and how the elements pinpointed by the computational approaches are involved in changing molecular and morphological phenotypes.

The phenotyping platforms of PHENOMIN - ICS area, adapted to study genetically modified mouse models, can also be used for preclinical studies, including the validation of therapeutic targets, as well as pharmaceutical and toxicological studies in mice.

The role of new genetic pathways in cancer biochemistry (the genome mutation profiles), the identification of the key targets and their validation, as well as utilization of new knock - out or knock - in animal models for such studies are among topics that will be discussed.

The results suggest that drugs that alter sarcosine metabolism might be useful in treating prostate cancer, but Chinnaiyan cautions that these Petri - dish findings still need further validation in animal models.

The Genetic engineering department in charge of the generation of customized and ready - to - use genetically modified mouse provides services and develops new tools in generation and validation of mouse model.

The main goal of these technologies is to accelerate the comprehension of our genome and of human diseases, and to promote therapeutic innovation through the validation of molecular targets and their effects in reference model organisms.

Based on their success to date in models of glaucoma, the researchers are making significant steps toward moving into human testing and validation of a biomarker for clinical use.

Modeling Kepler transit light curves as false positives: Rejection of blend scenarios for Kepler - 9, and validation of Kepler - 9d, a super-Earth-size planet in a multiple system

The validation of the procedure was done on the data extracted from simulated roots (see Appendix Text: Section S1.D) and is shown in Appendix Figs S5 — S7 for each model.

This section invites manuscripts describing (a) Linkage, association, substitution or positional mapping and epigenetic studies in any species; (b) Validation studies of candidate genes using genetically - engineered mutant model organisms; (c) Studies focused on epistatis and gene - environment interactions; (d) Analysis of the functional implications of genomic sequence variation and aim to attach physiological or pharmacogenomic relevance to alterations in genes or proteins; (e) Studies of DNA copy number variants, non-coding RNA, genome deletions, insertions, duplications and other single nucleotide polymorphisms and their relevance to physiology or pharmacology in humans or model organisms, in vitro or in vivo; and (f) Theoretical approaches to analysis of sequence variation.

Additional known locales where this species has been collected in New York City and its northern and eastern suburbs, southern Connecticut, and isolated southern New England areas were not included in model development, but were useful for model validation.

This step in and of itself biases the model to work successfully in cross validation although an argument could be made that this is acceptable because the gene list is already known to be relevant.

The need for a systematic approach to tractography validation and for a framework to perform statistical model testing in individual brains has been claimed (Pestilli Nature: Scientific Data 2015).

Godwin's findings are a validation of the MDI Biological Laboratory's unique research approach, which is focused on studying regeneration in a diverse range of animal models with the goal of gaining insight into how to trigger dormant genetic pathways for regeneration in humans.

He has developed laboratory and animal models of the tumor in its microenvironment, which have allowed for both identification of novel targets and validation of novel targeted therapies.

Researchers studying Mendelian and other genetic disorders in mice have new techniques and technologies to create new mouse models; paired with whole - exome sequencing, they have increased the rate of mutation discovery and validation tenfold.