Sentences with phrase «in molecular understanding»

Jeffrey Goldberg, MD, PhD, Bascom Palmer Eye Institute, University of Miami, observed that new opportunities for identifying glaucoma biomarkers have emerged thanks to advances in molecular understanding of the disease and in the fields of optics and physics.

Not exact matches

Still, researchers now have a far better understanding of the molecular pathways in the ear and how to regenerate hair cells and repair synaptic connections.

Experience in orphan disease drug development and an understanding of genetic concepts and molecular biology laboratory techniques is beneficial.

Richard Dawkins, in his celebrated book, The Selfish Gene, exemplifies the same position.3 And a similar reduction of biology to a molecular science may be found in the writings of E.O. Wilson, Ernst Mayr, Jacques Monod and numerous other highly respected scientific writers.4 In Chance and Necessity, for example, Monod gives one of the most forceful renditions of the view that biochemical analysis is «obviously» the sole avenue to understanding the secret of life.5 Decades ago Jacques Loeb had already set forth the program of inquiry still emulated today by many biologistin his celebrated book, The Selfish Gene, exemplifies the same position.3 And a similar reduction of biology to a molecular science may be found in the writings of E.O. Wilson, Ernst Mayr, Jacques Monod and numerous other highly respected scientific writers.4 In Chance and Necessity, for example, Monod gives one of the most forceful renditions of the view that biochemical analysis is «obviously» the sole avenue to understanding the secret of life.5 Decades ago Jacques Loeb had already set forth the program of inquiry still emulated today by many biologistin the writings of E.O. Wilson, Ernst Mayr, Jacques Monod and numerous other highly respected scientific writers.4 In Chance and Necessity, for example, Monod gives one of the most forceful renditions of the view that biochemical analysis is «obviously» the sole avenue to understanding the secret of life.5 Decades ago Jacques Loeb had already set forth the program of inquiry still emulated today by many biologistIn Chance and Necessity, for example, Monod gives one of the most forceful renditions of the view that biochemical analysis is «obviously» the sole avenue to understanding the secret of life.5 Decades ago Jacques Loeb had already set forth the program of inquiry still emulated today by many biologists:

You can be a creationist and a scientist, as long as your field has absolutely nothing to do with DNA research, such as cancer / molecular biology, genetics and microbio, because in those fields understanding how DNA changes and is likely to change is fundamental.

It is possible to understand a great deal about mind by analyzing it in terms of its molecular basis.

Rapid breakthroughs in genetic research, advances in molecular biology, and new reproductive technologies are enhancing our understanding of and responses to genetically inherited diseases.

«We need to have people who really understand the general technology,» says Melissa Kotterman, director and head of adeno - associated virus research at 4D Molecular Therapeutics (4DMT) in San Francisco, California, a company cofounded in 2012 by UC Berkeley bioengineer David Schaffer.

Scientists have gained a better molecular understanding of the region of the brain in individuals with epilepsy which — due to a developmental abnormality, trauma, stroke, or a growing tumor — has stopped responding to control signals, and this results in recurrent seizures.

The researchers hope these study findings will aid in understanding the complex human reproductive cycle and the occasional problems that originate on a molecular level.

Consequently, an in - depth understanding of the molecular workings holds hope for designing agents with just the desired properties that would act more precisely.

His research interests include the roles of zinc in proteins including zinc finger proteins, the mechanisms and systems biology of protein targeting to peroxisomes, and the development of detailed thermodynamic understanding of molecular recognition processes.

«We are in a scenario where we can collect massive amounts of genetic data using GWAS, but are realizing that does not provide the biological context we need in order to understand the results,» says Andy McCallion, Ph.D., assistant director of the human genetics graduate program and associate professor of molecular and comparative pathobiology at the Johns Hopkins University School of Medicine.

«If we can understand the chemical complexity of these ices in the molecular cloud, and how they evolve during the formation of a star and its planets, then we can assess whether the building blocks of life should exist in every star system,» said Melissa McClure of the Universiteit van Amsterdam, the principal investigator on a research project to investigate cosmic ices.

In doing so, the team has provided a molecular dynamics tool that allows for the study of various heat transfer problems at the nanoscale, including understanding and utilizing passive liquid flows.

By exploiting new molecular and genetic insights, the research, done in collaboration with Pierre de Wit from Wageningen Agricultural University in the Netherlands, provides a better understanding of the defense system of crop plants against the damaging pathogens that grow in the spaces between plant cells.

Muotri's work is a nice demonstration of the power of mini-brains to help understand the early, cellular features of neurological disorders, says Madeline Lancaster at the MRC Laboratory of Molecular Biology in Cambridge, UK, who developed the organoid - growing method Muotri used.

He claimed, «It challenged me to present a molecular biology concept that even a general audience can understand and in a format that is educationally applicable.»

Migraine is a debilitating disorder affecting around 1 in 7 people worldwide, but its molecular mechanisms remain poorly understood which makes developing new treatments challenging.

In recent years, epigenetics researchers have made great strides in understanding the many molecular sequences and patterns that determine which genes can be turned on and ofIn recent years, epigenetics researchers have made great strides in understanding the many molecular sequences and patterns that determine which genes can be turned on and ofin understanding the many molecular sequences and patterns that determine which genes can be turned on and off.

A research team from Wayne State University recently published a paper in the Journal of Clinical Investigation that provides a paradigm shift in the understanding of cellular and molecular mechanisms underlying diabetic peripheral neuropathy (DPN) and wound healing in the treatment of corneal and skin diabetic ulcers.

By understanding the molecular logic of how those modules can be combined in different ways, we can begin to reconstruct how this diversity evolved.»

«Our goal here was to understand the molecular underpinnings of an important evolutionary transition, not to create a «dino - chicken» simply for the sake of it,» said Bhullar, lead author of the study, published online May 12 in the journal Evolution.

Her research is part of growing evidence that has yielded an entirely new understanding of molecular differences reflected in the brain between men and women, and how outside forces can permanently imprint neurological circuitry in sex - based ways.

«I can learn from the molecular biologist in our group how phylogenic data shed new light on our understanding of the evolution of cyanobacteria in Earth history.

«I can remember in my second year thinking [that] in the... 50 years since Watson and Crick elucidated the structure of DNA, molecular biologists had been taking living systems apart and understanding the various pieces.

In the future, studies are aimed at using novel molecular approaches to selectively delete AMPK in specific brain regions associated with nicotine dependence to better understand the functional role of this protein in addictioIn the future, studies are aimed at using novel molecular approaches to selectively delete AMPK in specific brain regions associated with nicotine dependence to better understand the functional role of this protein in addictioin specific brain regions associated with nicotine dependence to better understand the functional role of this protein in addictioin addiction.

«In addition, there are plans for further molecular biological studies with the objective of understanding exactly how the 5 - LO inhibitors act on the leukaemic cells.»

«Understanding the fundamental properties of this class of proteins is very relevant,» said Elizabeth Gavis, the Damon B. Pfeiffer Professor in the Life Sciences and a professor of molecular biology.

Although the whole drive to understand the molecular basis of beer production involves modern tools that are used in biotechnology, such as real - time polymerase chain reaction (PCR), gene chips, proteomics, mass spectrometers, and so forth, genetic manipulation is not acceptable in any form — not in any of the raw materials or the yeast.

We hope that these new insights will allow us to increase our understanding of the molecular mechanisms that result in cancer and to more effectively treat this aggressive type of leukemia.»

The current Ebola virus outbreak in West Africa, which has claimed more than 2000 lives, has highlighted the need for a deeper understanding of the molecular biology of the virus that could be critical in the development of vaccines or antiviral drugs to treat or prevent Ebola hemorrhagic fever.

Using the latest molecular biology techniques, Myrick hopes to understand drug resistance in the parasite that causes the disease.

And once I got into brain biology, it became clear you needed to study the brain on the cellular level, and once you began to understand aspects of behavior in the cellular level, you wanted to understand the molecular level.

Rather than contributing to our understanding of life, Wolfram says Wade's discovery could help devise ways to build a molecular - scale computer, starting from tiny components like the cells in Life.

However, the molecular mechanism by which JUNO specifically recognizes IZUMO and participates in the sperm - egg adhesion step remains to be fully understood.

In addition to running his own lab, he directs the Applied Neurotherapeutic Research Group, a collaborative research initiative funded jointly by SFI and Wyeth, to understand the molecular underpinnings of changes in behavior and to identify new drug targets for diseases such as schizophreniIn addition to running his own lab, he directs the Applied Neurotherapeutic Research Group, a collaborative research initiative funded jointly by SFI and Wyeth, to understand the molecular underpinnings of changes in behavior and to identify new drug targets for diseases such as schizophreniin behavior and to identify new drug targets for diseases such as schizophrenia.

«This not only advances our understanding of how the body responds to cold, but could lead to new ways to control the amount of brown fat in the body, which has links to obesity, diabetes and fatty liver disease,» says senior author Ronald Evans, Howard Hughes Medical Institute investigator and holder of Salk's March of Dimes Chair in Molecular and Developmental Biology.

«Our study is a nice example of how the understanding of a disease on the molecular and cellular level results in new therapeutic options.

Next, the researchers hope to identify and understand those molecular mechanisms, which could provide new targets for antibiotics in the future.

Understanding the function of this gene — described this month in journal Molecular Psychiatry — could lead to more effective treatments for schizophrenia.

«Increasingly in the life sciences, developments are based on an understanding of processes at the molecular level, even where the molecules are large and in complex systems,» says Ashmore, «so an increased hiring of folk with a thorough understanding of the fundamentals is taking place.»

Intrigued by the molecular details of how enzymes worked, he next joined the lab of Michael Toney, where he set out to understand how electrons and protons move during catalysis by analyzing how mutations in the enzyme's functional site affected the reaction mechanism.

We don't yet fully understand what the potential of molecular machinery is, but there are many applications that can be developed once we develop a deep understanding of how motion takes place in solids.»

The problem is that scientists have long seen molecular diodes behaving in either of the two Marcus regimes in ways they did not understand.

«Understanding charge transfers in molecular electronics.»

«This research demonstrates our grasp of tunneling on a molecular system that is of vital importance to the understanding of atmospheric chemistry,» said Klippenstein, a distinguished fellow in Argonne's Chemical Sciences and Engineering Division who performed the theoretical calculations.

The science behind molecular charge transfer is well understood in the field of chemistry, and explained by the so - called Marcus Theory.

As a result, the emphasis in early development is on understanding the molecular underpinnings of disease and developing markers for therapeutic effects.

Jeremy Henley, Professor of Molecular Neuroscience in the University's School of Biochemistry in the Faculty of Medical and Veterinary Sciences, said: «These discoveries represent a significant advance and will have far - reaching implications for the understanding of memory, cognition, developmental plasticity and neuronal network formation and stabilisation.