«New MRI approach detects early liver tumors
in mouse model of human disease.»
The new Mount Sinai study reveals how loss of a protein called Sirtuin1 (SIRT1) affects the ability of blood stem cells to regenerate normally, at least
in mouse models of human disease.
Not exact matches
Gene therapy delivered to a specific part
of the brain reverses symptoms
of depression
in a
mouse model of the
disease — potentially laying the groundwork for a new approach to treating severe cases
of human depression
in which drugs are ineffective.
These findings allowed researchers to create a chimera virus: a
mouse virus with a
human viral gene that can be used to test molecules that inhibit
human LANA protein
in an animal
model of disease, treating not only
human herpes virus infection but also its associated cancers.
Researchers from Instituto de Medicina Molecular (iMM) Lisboa have created a chimera virus that allows the study
of molecules to treat cancers caused by
human herpes virus infection
in mice models of disease.
The behavioral tests used here
modeled one dimension
of the
disease — an inability to experience pleasure from normal activities — but not others, such as stress and anxiety, and probably tap into different brain mechanisms
in mice than
in humans, he says.
By directly manipulating a portion
of the prion protein - coding gene, Whitehead Institute researchers have created
mouse models of two neurodegenerative
diseases that are fatal
in humans.
We demonstrated that DENV serotype 2 (DENV2)-- specific
human monoclonal antibody (HMAb) 2D22 is therapeutic
in a
mouse model of antibody - enhanced severe dengue
disease.
The UT Southwestern group had previously used CRISPR - Cas9, the original gene - editing system, to correct the Duchenne defect
in a
mouse model of the
disease and
in human cells.
This was observed
in human ovarian cancer cells grown
in culture, and then
in mouse models of the
disease.
Desgrosellier said the team will follow up with
mouse models containing tumor fragments from patients to better reflect the diversity
of cell types present
in human disease.
Most animal studies
of the
disease are conducted with laboratory
mice that have been genetically engineered and bred to
model ALS, but for this research, investigators used rats with ALS because they more accurately portray the
disease's variable course
in humans.
«This research project is a prime example
of how
mouse models can help us to better understand cancer
diseases in human beings,» says Sabine Harlander.
By studying how these genes cause defects
in fly and
mouse models, we can improve our insights into the mechanisms related to
human disease,» said corresponding author and Dr. Hugo J. Bellen, professor
of neuroscience and molecular and
human genetics at Baylor College
of Medicine and an investigator at the Howard Hughes Medical Institute.
Mouse embryonic stem cells, reported
in 1981 by Martin Evans, Matthew Kaufman, and Gail Martin, have allowed scientists to generate genetically customized strains
of mice that have revolutionized studies
of organismic development and immunity and have provided countless
models of human disease.
In a novel animal study design that mimicked human clinical trials, researchers at University of California, San Diego School of Medicine report that long - term treatment using a small molecule drug that reduces activity of the brain's stress circuitry significantly reduces Alzheimer's disease (AD) neuropathology and prevents onset of cognitive impairment in a mouse model of the neurodegenerative conditio
In a novel animal study design that mimicked
human clinical trials, researchers at University
of California, San Diego School
of Medicine report that long - term treatment using a small molecule drug that reduces activity
of the brain's stress circuitry significantly reduces Alzheimer's
disease (AD) neuropathology and prevents onset
of cognitive impairment
in a mouse model of the neurodegenerative conditio
in a
mouse model of the neurodegenerative condition.
First author Antonio Di Meco and colleagues used a triple transgenic (3xTg)
mouse model that displays an AD - like phenotype, including cognitive decline, and Aβ and tau neuropathology characteristic
of the
disease in humans.
The researchers used
mouse models that mimic the
disease characteristics
of pulmonary hypertension and pulmonary fibrosis
in humans to study the effect
of triciribine, which inhibits production
of a protein called Akt1.
«We think that for the first time, we have a
mouse model of anorexia that closely resembles the conditions leading up to the
disease in humans,» said study leader Lori Zeltser, PhD, associate professor
of pathology & cell biology and a researcher
in the Naomi Berrie Diabetes Center.
Although genetically modified
mice have been used widely to
model neurodegenerative
diseases, they lack the typical neurodegeneration or overt neuronal loss seen
in human brains, says corresponding author Xiao - Jiang Li, MD, PhD, distinguished professor
of human genetics at Emory University School
of Medicine.
Using a
model of Parkinson's
disease in which the toxin MPTP, made famous
in book «The Case
of the Frozen Addicts,» induces Parkinson's - like symptoms
in humans and
mice, Dr. Smeyne showed that
mice infected with H1N1, even long after the initial infection, had more severe Parkinson's symptoms than those who had not been infected with the flu.
The new study is based on the development
of mouse models manifesting the
disease that causes megalencephaly, spasticity and ataxia
in humans.
In his Ph.D. project, Dr. Henri Leinonen investigated functional abnormalities
of the retina using
mouse models of human central nervous system
diseases.
In humans, α - synuclein would not necessarily turn out to be equally aggressive —
mouse models of neurodegenerative
diseases do not mimic
human disease very closely — but scientists are taking the possibility seriously.
These methods were used to test different attributes
of vision
in three distinct genetically engineered
mouse models of human CNS
diseases.
The finding, by researchers at the University
of Illinois at Chicago College
of Medicine, was reported July 16 at the Alzheimer's Association International Conference
in Copenhagen by Mary Jo LaDu, who
in 2012 developed a transgenic
mouse that is now regarded as the best animal
model of the
human disease.
But Franklin and others suspect that
in their zeal to clean up, facilities may have wiped out some
of the microbial complexity that makes
mice useful
models for
human disease.
Functional changes
of the retina were found
in three
mouse models of human CNS
diseases whose phenotype, age
of onset and pathological mechanism clearly differ from each other.
The phosphorylation
of eIF2alpha, which decreases protein synthesis, was previously found at elevated levels
in both
humans diagnosed with Alzheimer's and
in Alzheimer's
Disease (AD)
model mice.
To determine the effect
of gastric acid suppression on the progression
of chronic liver
disease, Schnabl's team looked at
mouse models that mimic alcoholic liver
disease, NAFLD and NASH
in humans.
However, Dr. Kissler's group discovered that reducing levels
of the RGS1 protein did not slow the progression
of the
disease in mouse models, suggesting that it may not offer much potential for
human treatment.
In recent years, researchers have found that both
humans with Alzheimer's
Disease and AD
model mice have relatively high levels
of eIF2alpha phosphorylation.
-- 90 percent
of genes associated with
disease are identical
in the
human and the
mouse, supporting the use
of mice as
model organisms.
«We hypothesized that this might explain why laboratory
mice, while paramount for understanding basic biological phenomena, are limited
in their predictive utility for
modeling complex
diseases of humans and other free - living mammals,» said Rosshart.
The similarity
of the
mouse and
human genetic make - up means that genes associated with
disease in humans can be studied and further investigated
in mouse models.
Investigating
mouse models for biological for research The congress aims to promote the International Mouse Phenotyping Consortium (IMPC) mouse lines, importance of mouse phenotyping & clinical and drug discovery collaboration, to present progresses performed by IMPC with regards CRISPR editing genome, rare diseases, microbiota and ageing pipeline, as well as illustration of examples of scientific projects about «Animal models for human diseases» and recent developments in mouse models phenotyping ima
mouse models for biological for research The congress aims to promote the International
Mouse Phenotyping Consortium (IMPC) mouse lines, importance of mouse phenotyping & clinical and drug discovery collaboration, to present progresses performed by IMPC with regards CRISPR editing genome, rare diseases, microbiota and ageing pipeline, as well as illustration of examples of scientific projects about «Animal models for human diseases» and recent developments in mouse models phenotyping ima
Mouse Phenotyping Consortium (IMPC)
mouse lines, importance of mouse phenotyping & clinical and drug discovery collaboration, to present progresses performed by IMPC with regards CRISPR editing genome, rare diseases, microbiota and ageing pipeline, as well as illustration of examples of scientific projects about «Animal models for human diseases» and recent developments in mouse models phenotyping ima
mouse lines, importance
of mouse phenotyping & clinical and drug discovery collaboration, to present progresses performed by IMPC with regards CRISPR editing genome, rare diseases, microbiota and ageing pipeline, as well as illustration of examples of scientific projects about «Animal models for human diseases» and recent developments in mouse models phenotyping ima
mouse phenotyping & clinical and drug discovery collaboration, to present progresses performed by IMPC with regards CRISPR editing genome, rare
diseases, microbiota and ageing pipeline, as well as illustration
of examples
of scientific projects about «Animal
models for
human diseases» and recent developments
in mouse models phenotyping ima
mouse models phenotyping imaging.
Since genetic loss
of aP2
in mouse models and
in humans results
in lowered risk
of cardiometabolic
disease, the molecule offers an exciting opportunity for new intervention strategies.
This
mouse model for AIDS dementia mimics several features
of the
disease process found
in humans.
She works under the direct supervision
of Dr. Lamba to conduct research to develop strategies to restore vision
in mouse models generated to mimic
human retinal degeneration
diseases.
A very large number
of changes have been discovered
in HD
model mice and then subsequently observed
in human HD patients, suggesting the
mice are useful research tools, even if they don't really have Huntington's
disease.
«Our decision to procure these knockout
mouse lines and data and make them available to the research community will yield tremendous benefits, both
in the short and long terms,» said NIH Director Elias A. Zerhouni, M.D. «This trans - NIH initiative will place important
mouse models into the hands
of researchers, speeding advances
in the understanding
of human disease and the development
of new therapies.
«This is an interesting paper presenting a potentially useful preventative therapy for Alzheimer's
disease but, while
mouse models are very useful, we have to be very careful about the interpretation
of the data
in relation to the
human condition.
The massive number
of cells within the OSVZ
of humans «tells us we have to be careful when
modeling human brain
diseases in mice,» says Kriegstein.
Furthermore, new genome - editing technologies such as CRISPR / Cas9 now enable the efficient derivation
of precision
disease models incorporating patient - specific genetic variants as a means
of recapitulating essential aspects
of human disease in mouse and other
model organisms.
PHENOMIN's involvement
in the IMPC will fulfill a key item
of the the National Alliance for life sciences and health (AVIESAN) strategic plan that consists
in applying
mouse genetics to analyze the mechanisms
of disease and to use this knowledge for advancing fundamental research and
human health (AVIESAN report on the use and needs
of mouse models in the French scientific community, 2010).
In recent years, researchers have developed so - called «senolytic» drugs that wipe out senescent cells in aging mice and mouse models of age - related disease, exploiting the high dependence of these cells on specific biochemical survival pathways.9, 10 In these studies, senolytic drugs have restored exercise capacity9 and formation of new blood and immune precursor cells11 in aging mice to near youthful norms, and prevented or treated mouse models of diseases of aging like osteoarthritis, 12 fibrotic lung disease, 13 hair loss, 14 atherosclerosis, 15,16 and age - related diseases of the heart itself.9 UNITY Biotechnology is leading a growing charge toward the clinic, with human clinical trials expected to begin in 201
In recent years, researchers have developed so - called «senolytic» drugs that wipe out senescent cells
in aging mice and mouse models of age - related disease, exploiting the high dependence of these cells on specific biochemical survival pathways.9, 10 In these studies, senolytic drugs have restored exercise capacity9 and formation of new blood and immune precursor cells11 in aging mice to near youthful norms, and prevented or treated mouse models of diseases of aging like osteoarthritis, 12 fibrotic lung disease, 13 hair loss, 14 atherosclerosis, 15,16 and age - related diseases of the heart itself.9 UNITY Biotechnology is leading a growing charge toward the clinic, with human clinical trials expected to begin in 201
in aging
mice and
mouse models of age - related
disease, exploiting the high dependence
of these cells on specific biochemical survival pathways.9, 10
In these studies, senolytic drugs have restored exercise capacity9 and formation of new blood and immune precursor cells11 in aging mice to near youthful norms, and prevented or treated mouse models of diseases of aging like osteoarthritis, 12 fibrotic lung disease, 13 hair loss, 14 atherosclerosis, 15,16 and age - related diseases of the heart itself.9 UNITY Biotechnology is leading a growing charge toward the clinic, with human clinical trials expected to begin in 201
In these studies, senolytic drugs have restored exercise capacity9 and formation
of new blood and immune precursor cells11
in aging mice to near youthful norms, and prevented or treated mouse models of diseases of aging like osteoarthritis, 12 fibrotic lung disease, 13 hair loss, 14 atherosclerosis, 15,16 and age - related diseases of the heart itself.9 UNITY Biotechnology is leading a growing charge toward the clinic, with human clinical trials expected to begin in 201
in aging
mice to near youthful norms, and prevented or treated
mouse models of diseases of aging like osteoarthritis, 12 fibrotic lung
disease, 13 hair loss, 14 atherosclerosis, 15,16 and age - related
diseases of the heart itself.9 UNITY Biotechnology is leading a growing charge toward the clinic, with
human clinical trials expected to begin
in 201
in 2019.
PHENOMIN - ICS services will ultimately help the scientific community
in the use the
mouse model, first to develop a complete functional annotation
of the
human genome and second to better understand
human diseases and their underlying physiological and pathological basis.
Following a Forward Genetics approach, Fleming researchers identified a novel neurological
mouse model caused by a functional mutation
in the Slc25a46 gene, a new pathogenic target
in a wide spectrum
of human neurological
diseases, including optic atrophy, Charcot - Marie - Tooth type 2, Leigh syndrome, progressive myoclonic ataxia and lethal congenital pontocerebellar hypoplasia.
It should be noted, however, that while a study on senescent cell ablation
in genetically normal
mice would provide at least some evidence on the effect
of senescent cells (and their ablation) on promoting cancer, even such a study would likely show less effect than could be anticipated
in a large mammal
model, since even normally - aging
mice rarely suffer metastatic
disease to the extent
of aging
humans, as sheer primary tumor volume is generally sufficient to be fatal to
mice.
Using genetic and epigenetic analyses coupled with powerful perturbation technologies to test gene functions
in human cells and
mouse models, we hope to identify the critical drivers
of this
disease and the basis for therapeutic responses.