Sentences with phrase «in multiple cell types»

PDGFRα is a cell surface tyrosine kinase receptor involved in organ development and tumor progression, it is present in multiple cell types such as mesenchymal cells, neurons, astrocytes, megakaryocytes and oligodendrocyte progenitor.

Not exact matches

In the clearest possible case, the ANT - OAR cell would differ from a zygote on all of the parameters noted above: The ANT - OAR cell would have a pattern of gene expression that is clearly distinct from a zygote; it would generate a homogeneous population of cells rather than multiple cell types; it would undergo simple cleavage divisions and not produce any multicellular structures.

Breech Twins and higher order multiples Previous CS Pre-Eclampsia Placenta praevia Cervical incompetence Previous late stillbirth Previous premature birth Grand multiparty Age under 18 Age over 35 Smoking Drug use Severe mental health issue Epilepsy Type 1 diabetes Type 2 diabetes Gestational diabetes Asthma GBS positive Abnormal antibodies Transplant recipient Congenital heart disease Known foetal abnormality Immunosuppressive medication MS Physical disability Intellectual disability Hypothyroidism Hyperthyroidism Previous shoulder dystocia Previous 3rd or 4th degree tear Sickle Cell anaemia BMI under 18 or over 35 at conception Previous massive PPH APH in current pregnancy HIV / AIDS Hepatitis B or C Active TB IUGR Oligohydramnios Polyhydramnios Child previously removed from custody because of abuse Uterine abnormalities such as uterine septum or double uterus Previous uterine surgery for fibroids Chronic renal problems Hypertension Auto immune condition Previous stroke or blod clot Cancer Domestic violence or abusive home Prisoners Homeless women

(borrowed from Dr Kitty) Breech Twins and higher order multiples Previous CS Pre-Eclampsia Placenta praevia Cervical incompetence Previous late stillbirth Previous premature birth Grand multiparty Age under 18 Age over 35 Smoking Drug use Severe mental health issue Epilepsy Type 1 diabetes Type 2 diabetes Gestational diabetes Asthma GBS positive Abnormal antibodies Transplant recipient Congenital heart disease Known foetal abnormality Immunosuppressive medication MS Physical disability Intellectual disability Hypothyroidism Hyperthyroidism Previous shoulder dystocia Previous 3rd or 4th degree tear Sickle Cell anaemia BMI under 18 or over 35 at conception Previous massive PPH APH in current pregnancy HIV / AIDS Hepatitis B or C Active TB IUGR Oligohydramnios Polyhydramnios Child previously removed from custody because of abuse Uterine abnormalities such as uterine septum or double uterus Previous uterine surgery for fibroids Chronic renal problems Hypertension Auto immune condition Previous stroke or blod clot Cancer Domestic violence or abusive home Prisoners Homeless women

For unknown reasons our immune system attacks healthy cells, tissues and organs in a process called autoimmunity, which can result in diseases such as multiple sclerosis, type 1 diabetes, lupus or rheumatoid arthritis.

In newborn mammals, the SVZ is the biggest depot for the precursor cells that migrate to populate various brain regions, and differentiate into multiple cell types.

The olfactory system comprises six million to 10 million receptor cells (of which there are nearly 400 different types) and links to multiple brain structures and neural pathways, including those involved in memory, emotion and movement.

Whether investigating fat cells, immunotherapy or use of the CRISPR - Cas 9 gene - editing tool, which a federal panel recently approved for a select number of patients suffering from three types of cancers, including multiple myeloma, approaches beyond attacking cancer cells are needed in the fight against many cancers.

Rewinding skin cells back to their origins in the womb could provide a powerful new vaccine against multiple types of cancer.

They discovered that genetic variation influencing a person's risk for multiple sclerosis, rheumatoid arthritis, and type 1diabetes is more likely to control gene activity in T cells than in monocytes.

To extend their initial findings, the researchers seek to understand the signals that coax these cells to develop, and whether they play roles in other autoimmune diseases, such as lupus, multiple sclerosis, and type 1 diabetes.

In the case of type 1 diabetes, it destroys the insulin - producing cells in the pancreas, and in multiple sclerosis it strikes the central nervous systeIn the case of type 1 diabetes, it destroys the insulin - producing cells in the pancreas, and in multiple sclerosis it strikes the central nervous systein the pancreas, and in multiple sclerosis it strikes the central nervous systein multiple sclerosis it strikes the central nervous system.

Though a range of developmental scenarios in multiple brain regions is surely at work in ASDs, the researchers said the ability to place these specific genetic mutations in one specific set of cells — among hundreds of cell types in the brain, and at a specific point in human development — is a critical step in beginning to understand how autism comes about.

Though most of these proteins are present in multiple root cell types, the researchers found, their statistical models and experiments in living plants suggest the combined effect is to activate the Short - root master switch in some cells but not others.

The device, part of the Lab's iCHIP (in - vitro Chip - Based Human Investigational Platform) project, simulates the central nervous system by recording neural activity from multiple brain cell types deposited and grown onto microelectrode arrays.

Dor's own group reports this week that its technique for tracing the origin of circulating DNA detected the expected type of cell death in people with pancreatic cancer, type 1 diabetes, multiple sclerosis, and brain injuries.

«This study focused on the development of the neocortex, but we aim to analyze multiple brain regions and developmental stages to achieve a more comprehensive atlas of cell types in the developing human brain,» Kriegstein said.

Multiple myeloma is a blood cancer that forms in a type of white blood cell called a plasma cell.

Theoretically, such stem cells can form any of the body's cell types and could be used in new treatments for Parkinson's disease, diabetes, multiple sclerosis, cardiac disease, and spinal cord injuries.

Cancer cells resemble stem cells not because they can turn into other cell types, but because in developmental terms, they seem to go in the opposite direction: they begin to run through multiple layers of stop signs and barricades and just keep on multiplying.

«Because Th17 cells have been linked to a number of autoimmune diseases, including multiple sclerosis, we thought our compound might inhibit Th17 cells in type 1 diabetes and possibly interfere with disease progression,» said Solt.

In lingual slices, type III cells show intracellular calcium responses to multiple stimuli, including sweeteners (Tomchik et al., 2007), likely due to secondary activation via sweet - responsive type II cells.

In fact, while Islet cell autoantibodies, or IA, are considered a red flag for type 1 diabetes, not every child with IA will progress to full - blown disease, She says, although multiple autoantibodies definitely increase that risk.

Oligodendrocytes, a type of brain cell that plays a crucial role in diseases such as multiple sclerosis, are more diverse than have previously been thought, according to a new study led by Sten Linnarsson, Karolinska Institutet / SciLifeLab and Gonçalo Castelo - Branco, Karolinska Institutet.

These cells are cancerous yet have properties of stem cells: self - renewal and the ability to differentiate into multiple cell types that occurs in tumors.

New studies in mice have shown that immature stem cells that proliferate to form brain tissues can function for at least a year — most of the life span of a mouse — and give rise to multiple types of...

Myeloma — also referred to as multiple myeloma or plasma cell myeloma — is a cancer that originates in plasma cells, a type of white blood cell that makes antibodies.

Multiple Ca2 + - Dependent Mechanisms Regulate L - Type Ca2 + Current in Retinal Amacrine Cells.

«The best case scenario is that from this one very accessible and highly proliferative source of stem cells, we will be able to obtain multiple different cell types that can be used for a broad range of applications in regenerative medicine,» he said.

Multiple myeloma cells are abnormal plasma cells (a type of white blood cell) that build up in the bone marrow and form tumors in many bones of the body.

Myeloma — also referred to as multiple myeloma or plasma cell myeloma — is a cancer that originates in plasma cells, a type of white blood cell that make antibodies.

In the study, the researchers compared how well CRISPRi and CRISPR - Cas9 silenced a particular gene that controls iPSC pluripotency — the capability of iPSCs to turn into multiple cell types.

Therefore, it is necessary to establish multiple independent iPS cell lines from individual donors to ensure efficient generation of various types of functional cells for future application in the treatment of diseases.

The first cohort of type 1 diabetes patients is receiving multiple small - format cell - filled devices called sentinels in order to evaluate safety and implant viability.

Characterization of a variant of human adenovirus type 2 which multiples efficiently in simian cells

Using red blood cells modified to carry disease - specific antigens, a team of scientists from Whitehead Institute and Boston Children's Hospital have prevented and alleviated two autoimmune diseases — multiple sclerosis (MS) and type 1 diabetes — in early stage mouse models.

February 10, 2015 New screening tool could speed development of ovarian cancer drugs University of Chicago Medicine researchers have built a model system that uses multiple cell types from patients to rapidly test compounds that could block the early steps in ovarian cancer metastasis.

The complex networks, interactions, and responses of immune cells produce diverse cellular ecosystems composed of multiple cell types, accompanied by genetic diversity in antigen receptors.

University of Chicago Medicine researchers have built a model system that uses multiple cell types from patients to rapidly test compounds that could block the early steps in ovarian cancer metastasis.

Hereditary cancer syndromes are caused by variants in genes that control cell growth in multiple tissue types.

Other types of stem cells are capable of creating multiple different cell types, but not all the cell types in the body.

Now it exists in multiple forms in most of the prepared food available to us (even the sugar - free options) and it perpetuates overall inflammation, dumps fat on our liver (non-alcoholic fatty liver disease); makes our cells resistant to the effects of insulin (insulin resistant); and then gives us metabolic syndrome, abdominal obesity, cardiovascular disease and type II diabetes.

It looks like nature has provided us with multiple types of antioxidants in plant foods for a reason — so they can work together to offset the type of cell damage that can lead to health problems and aging.

Melatonin is important for the proper functioning of your immune system, scavenging free radicals, reducing inflammation, and helping your body to rid itself of cancer cells; multiple studies point to the role of melatonin in protecting you from multiple types of cancer, including breast cancer

Honda's next - generation fuel cell - electric vehicle will feature a fuel cell powertrain packaged completely in the engine room of the vehicle, allowing for efficiencies in cabin space as well as flexibility in the potential application of FC technology to multiple vehicle types in the future.

Also: — Docs to go with track changes and «tabs» (like on the browser so I can have multiple documents open)-- Sheet to go that will let me re-size and format cells; can support split cell view; and will let me tap cells instead of typing in cell numbers when building formulas.

Although genetic susceptibility appears to be a prerequisite in type 1 diabetics, multiple environmental factors likely initiate β - cell autoimmunity, which, once begun, proceeds by common pathogenic pathways (74).