A better understanding of gut bacteria's
role in multiple sclerosis may identify novel drug targets and pathways to improved health.
The government created a bit of a problem for itself when it allowed GW Pharmaceuticals to grow cannabis under license in order to produce Sativex - a cannabis tincture used to treat spasticity
in multiple sclerosis patients.
Members of the media are invited to the panel discussion, A Brighter Future: Frontiers
in Multiple Sclerosis Research and Treatment and to the afternoon sessions which will include an update on MS research in London, Ontario, and the keynote lecture from V. Wee Yong, PhD, the 2017 J. Allyn Taylor International Prize in Medicine recipient.
Genova H et al: Examination of cognitive
fatigue in multiple sclerosis using functional magnetic resonance imaging and diffusion tensor imaging» was published on Nov. 1 in PLoS One.
SAN FRANCISCO, CA — Scientists at the Gladstone Institutes have defined for the first time a key underlying process
implicated in multiple sclerosis (MS)-- a disease that causes progressive and irreversible damage to nerve cells in the brain and spinal cord.
Kessler Foundation investigators have previously supported the cognitive reserve hypothesis in persons with multiple sclerosis, demonstrating that lifetime intellectual enrichment protects patients from cognitive impairment, as published
in Multiple Sclerosis Journal.
Impact of depression, fatigue, and global measure of cortical volume on cognitive impairment in multiple sclerosis
Combined structural and functional patterns discriminating upper limb motor disability
in multiple sclerosis using multivariate approaches
Now a research team at Nottingham has found a way to use clinical MRI to distinguish between MS lesions and other brain white spots which are found in MS.. The study is
published in the Multiple Sclerosis Journal.
«Working memory mediates the relationship between intellectual enrichment and long - term
memory in multiple sclerosis: An exploratory analysis of cognitive reserve» was published online ahead of print by the Journal of the International Neuropsychological Society on July 14.
«The study results elucidate the molecular mechanisms underlying disease
progression in multiple sclerosis models, providing a basis for future clinical trials to determine safety and efficacy of these chemical agents in humans with demyelinating disorders,» says Patrizia Casaccia, MD, PhD, Professor of Neuroscience, Genetics and Genomic Sciences at Mount Sinai and senior author of the study.
Kessler Foundation scientists correlated functional magnetic resonance imaging (fMRI) findings with the negative impact of outdoor temperature on cognitive
functioning in multiple sclerosis (MS).
«Cerebral microbleeds in MS are associated with increased risk for disability: An important predictor of dementia may also point to significant
disability in multiple sclerosis, a new study finds.»
Due to the fact that no human studies could be researched on this promising therapeutic approach, the «IGEL» study (A randomized controlled pilot study comparing the effects of intermittent fasting and the ketogenic low - glycemic diet on the quality of
life in multiple sclerosis) was brought to life.
Beyond Alzheimer's, Genentech is working on other neuroscience
programs in multiple sclerosis and rare neurologic conditions like Huntington's and spinal muscular atrophy, at a time when other pharmaceutical companies have largely left the space.
The value of
stock in a multiple sclerosis drug company - which includes large holdings by members of Congress - collapsed Tuesday when company officials announced the drug failed during recent clinical trials.
(Leavitt VM, Sumowski JF, Chiaravalloti N, DeLuca J. Warmer outdoor temperature is associated with worse cognitive
status in multiple sclerosis.
There was some evidence that it had reversed damage to nerves, but the result was not statistically significant, says Alasdair Coles, a neuroscientist at the University of Cambridge, UK, and the UK chief investigator of the Comparison of Alemtuzumab and Rebif
Efficacy in Multiple Sclerosis (CARE - MS) I trial.
The investigators pointed out its possible relevance in treating diseases associated with a lack of myelin, with particular
interest in multiple sclerosis.
Montani is now studying if the enzyme is also crucial for the cells which myelinate the brain during postnatal development and if it plays a role in repairing myelin after a lesion, as the ones
present in multiple sclerosis patients.
In a new study published in the journal Frontiers in Neurology, a team of researchers led by the University of Surrey, have identified a rogue
protein in multiple sclerosis, which attacks the body's central nervous system.
Inhibiting RGMa with its
antibody in multiple sclerosis (MS) in rats promotes motor recovery after spinal cord injury and improve disease scores,» explains Kana Harada, lead author of the team's study recently published in Scientific Reports.
This work, which has been done in collaboration with the group of Dr Carmen Guaza of the Instituto Cajal in Madrid, and Dr X. Montalban and Dr M. Comabella of the Val d'Hebron Institut de Recerca in Barcelona, constitutes a significant advance in the understanding of the biology of the ANKRD55 gene and of the proteins it expresses, given that a new player has been discovered in the neuro - inflammation process that takes
place in Multiple Sclerosis.
«This concept has significant therapeutic implications and will drive the development of new therapies because it implies that MS will produce significant disability if suffered for enough time in all patients,» says co-author Dr. Pablo Villoslada, Head of the IDIBAPS research group in Pathogenesis and new
treatments in multiple sclerosis and coordinator of the study.
This week we hear stories on the gut microbiome's
involvement in multiple sclerosis, how wildfires start — hint: It's almost always people — and a new record in quantum computing with Online News Editor David Grimm.
Antibodies to the RNA Binding Protein Heterogeneous Nuclear Ribonucleoprotein A1 Colocalize to Stress Granules Resulting in Altered RNA and Protein Levels in a Model of
Neurodegeneration in Multiple Sclerosis.
The article, «Neuro - ophthalmic syndromes and processing
speed in multiple sclerosis,» (doi: 10.1097 / WNO.0000000000000272) was published in the Journal of Neuro - Ophthalmology.