Sentences with phrase «in nematodes»

NRF2 / SKN - 1: Increased levels of NRF2 in mice or its homolog SKN - 1 in nematodes results in slower aging and modestly extended life spans - normally NRF2 levels decline with age.

ACE inhibitors are used in medicine to treat hypertension, but the mechanism by which they extend life in nematodes - not a species that has to worry about high blood pressure - remains to be explored.

Our results demonstrate the existence of a perilipin - related regulation of fat metabolism in nematodes and provide new possibilities for functional studies of lipid metabolism.

Our results demonstrate that perilipin - related regulation of fat metabolism is conserved in nematodes and provide new possibilities for functional studies of lipid metabolism.

This strategy has been used in yeast by Lee et al (2013) and in nematodes by El Mouridi et al (2017) and Heppert et al (2016).

Perilipins have been identified in organisms as diverse as metazoa, fungi, and amoebas but strikingly not in nematodes.

In the other study, Anne Brunet, a geneticist at Stanford University in Palo Alto, California, and colleagues found that in nematodes, the mere trace of one sex also seems to reduce the survival of the other.

Now researchers have found that at least one of these genes also functions in nematodes.

Researchers use heated magnetic nanoparticles to manipulate nerve cells and control simple behavior in nematodes

With few exceptions, these cells still die, suggesting that, in nematodes, engulfment is not necessary for most programmed deaths.

Researchers discovered RNA interference, or RNAi for short, in nematodes in 1995.

In 2016, for example, scientists at Florida Atlantic University and the Scripps Research Institute for the first time induced seizures in nematodes, microscopic worms with just 302 brain cells.

One of his colleagues studies aging in nematodes (Caenorhabditis elegans), and he's considering changing his model organism.

The key proteins at work in the nematodes have highly similar counterparts in humans, suggesting that similar regulatory pathways may operate in people.

In one of her experiments she studied gene expression in nematodes subjected to 15 - G pressures, using Ames's human centrifuge.

Did you know that we have only a third the number of genes present in a nematode?

Finding a second selfish element in the nematode, he says, suggests that these may not be as rare in animals as people have thought.

«But the nervous system in both nematode worms and humans is organized into small functional units called neural circuits, where neurons communicate with each other to control a simple outcome, such as behavior.»

The two postembryonic touch receptor neurons in the nematode Caenorhabditis elegans arise from essentially identical cell lineages and have the same ultrastructural features.

In their study, which has just been published in the journal PNAS, the researchers demonstrate that the defence protein docks on to a specific target in the nematode: a modified sugar found on the surfaces of the worm's intestinal cells but also on those of molluscs like snails.

Her research is in nematode chemical ecology and plant - nematode interaction.

Previously, it has been used in nematode worms to trigger egg - laying, and in mice to relieve depression and paralysis.

Esvelt plans to develop CRISPR gene drives in nematode worms — a fast - reproducing model organism — that are designed to spread a genetic modification in a local setting and then fizzle out, a concept that other scientists are pursuing.

Additionally, Rajewsky and his collaborators mined databases and discovered thousands of different circRNAs in nematode worms, mice and humans.

An intriguing finding in nematode worms suggests that having a little bit of extra fat may help reduce the risk of developing some neurodegenerative diseases, such as Huntington's, Parkinson's and Alzheimer's diseases.

Scientists at the Buck Institute combined mutations in two pathways well - known for lifespan extension and report a synergistic five-fold extension of longevity in the nematode C. elegans.

About 70 per cent of the genes identifed so far in the nematode sequencing project bear little or no resemblance to any genes identified previously.

The biogenic amines serotonin and octopamine are present in the nematode Caenorhabditis elegans.

The finding hinted that genes affecting longevity in the nematode might hold relevance for humans, too.

This in turn should help geneticists work out the functions of human genes, many of which are likely to have sequences similar to those found in the nematode.

In 1985, as a new assistant professor at Harvard, he started his own lab at Massachusetts General Hospital in Boston, focusing on developmental genetics in the nematode.

They follow individual proteins in clusters of stem cells, trace cellular migration in a developing fruit fly larva, and observe muscle contractions in a nematode embryo (see video, above), among other tasks.

Previously, it has been used in nematode worms to trigger them to lay eggs, and mice to relieve depression and paralysis.

Later, when Hart embarked on an ambitious project to study human neurological disease in the nematode C. elegans, she encountered some resistance to her ideas.

In the nematode Caenorhabditis elegans, insulin / IGF signaling regulates adult longevity.

All That Jazz After playing saxophone in Tel Aviv, Amsterdam, and Boston, Adam Antebi has stepped up to his most challenging gig yet: deciphering the links between endocrinology and longevity in the nematode.

Meanwhile, Esvelt and his colleagues are studying the CRISPR gene - drive system in the nematode Caenorhabditis elegans to learn more about what happens to a population as engineered DNA is passed down through generations, accumulating mutations as it goes.

Allyson Whittaker and Paul Sternberg of the California Institute of Technology, Pasadena, study the nervous control of mating behaviour in the nematode Caenorhabditis elegans.

A team of biophysicists from the State University of New York (S.U.N.Y.) at Buffalo used magnetic nanoparticles to control heat - activated protein gates called ion channels embedded in the membranes of nerve cells, allowing the researchers to stimulate a simple reflex in nematode worms at will.

Whereas in the nematode experiment the researchers targeted nanoparticles to temperature - sensitive ion channels that naturally exist in the membranes of the worms» nerve cells, the scientists inserted the gene for a heat - activated ion channel called TRPV1 into the human and rat cells.

In the nematode Caenorhabditis elegans, the presence of males accelerated aging and shortened the life span of individuals of the opposite sex (hermaphrodites), including long - lived or sterile hermaphrodites.

With an eye toward shifting that balance, the scientists inserted into mice a gene called fat - 1, which in nematode worms produces an enzyme that converts omega - 6 fats into omega - 3 fats.

This discovery offers promising possibilities for functional studies of lipid metabolism in a nematode model system.

The glaring difference in fat storage and metabolism seemed to be the absence of perilipin in nematode genomes.

CRTC1: A reduced amount of CRTC1 can extend life in nematode worms, and is probably involved in the calorie restriction response.

Full Toxicity Assessment of Genkwa Flos and the Underlying Mechanism in Nematode Caenorhabditis elegans.

Our strategy is based on the combination of genetics, imaging, electrophysiology and biochemistry in the nematode Caenorhabditis elegans (for more information on C. elegans see «an overview of the model organism C. elegans»).

BCAT - 1: Inhibition of bcat - 1 is shown to extend life in nematode worms, possibly via a form of hormesis or calorie restriction effect by blocking the processing of some dietary molecules.

Translocation and neurotoxicity of CdTe quantum dots in RMEs motor neurons in nematode Caenorhabditis elegans.

Daniel will be looking at the relationship between metal toxicity and aging in the nematode worm C. elegans — a new area of inquiry in the Lithgow lab.