Sentences with phrase «in new cell line»

Not exact matches

In all likelihood, soon after he is sworn in, federal dollars will start flowing toward research on new embryonic stem - cell lines, bringing with it new battles to fighIn all likelihood, soon after he is sworn in, federal dollars will start flowing toward research on new embryonic stem - cell lines, bringing with it new battles to fighin, federal dollars will start flowing toward research on new embryonic stem - cell lines, bringing with it new battles to fight.

Not surprisingly, President Obama received high marks from the journal, largely because his response to the question of whether he would lift Bush's ban on the federal funding of new embryonic stem - cell lines is in line with the view of most in the scientific community.

In fact, the latest research in epigenetics, stem cells, and the developmental origins of health and disease is unlocking a whole new line of understanding of what breastmilk contains and its role in developmenIn fact, the latest research in epigenetics, stem cells, and the developmental origins of health and disease is unlocking a whole new line of understanding of what breastmilk contains and its role in developmenin epigenetics, stem cells, and the developmental origins of health and disease is unlocking a whole new line of understanding of what breastmilk contains and its role in developmenin development.

In addition to opening the door to new studies in the «economics» of cells, the findings may have medical implications, as intestinal lining plays an important role in the both absorption of nutrients and protecting the bodIn addition to opening the door to new studies in the «economics» of cells, the findings may have medical implications, as intestinal lining plays an important role in the both absorption of nutrients and protecting the bodin the «economics» of cells, the findings may have medical implications, as intestinal lining plays an important role in the both absorption of nutrients and protecting the bodin the both absorption of nutrients and protecting the body.

In this study published in Cell Reports, Alexandra Van Keymeulen and colleagues generated a new transgenic line - allowing lineage tracing of ER + luminal cells to investigate luminal cell heterogeneity and identify the origin of ER + luminal cells and the mechanisms regulating their pubertal expansion and adult maintenancIn this study published in Cell Reports, Alexandra Van Keymeulen and colleagues generated a new transgenic line - allowing lineage tracing of ER + luminal cells to investigate luminal cell heterogeneity and identify the origin of ER + luminal cells and the mechanisms regulating their pubertal expansion and adult maintenancin Cell Reports, Alexandra Van Keymeulen and colleagues generated a new transgenic line - allowing lineage tracing of ER + luminal cells to investigate luminal cell heterogeneity and identify the origin of ER + luminal cells and the mechanisms regulating their pubertal expansion and adult maintenaCell Reports, Alexandra Van Keymeulen and colleagues generated a new transgenic line - allowing lineage tracing of ER + luminal cells to investigate luminal cell heterogeneity and identify the origin of ER + luminal cells and the mechanisms regulating their pubertal expansion and adult maintenacell heterogeneity and identify the origin of ER + luminal cells and the mechanisms regulating their pubertal expansion and adult maintenance.

The scientists then tested three new mTOR inhibitors currently under development (pp242, AZD8055 and INK128) in combination with the chemotherapies AraC, Etoposide and Cisplatin to see how they affected laboratory lines of leukemia cells and mouse models of the disease.

In a new study published in the journal Development, the KU Leuven researchers show that individual or small groups of cells from uterus biopsies can be made to grow into three - dimensional structures that show many of the features of the womb lining, including the ability to produce mucuIn a new study published in the journal Development, the KU Leuven researchers show that individual or small groups of cells from uterus biopsies can be made to grow into three - dimensional structures that show many of the features of the womb lining, including the ability to produce mucuin the journal Development, the KU Leuven researchers show that individual or small groups of cells from uterus biopsies can be made to grow into three - dimensional structures that show many of the features of the womb lining, including the ability to produce mucus.

Wayne Hellstrom of Tulane University in New Orleans, Louisiana, and colleagues, extracted stem cells from fat and placed them onto layers of tissue taken from the lining of pig intestine.

Today, MD Anderson urges all its scientists to fingerprint new cell lines as soon as they arrive in the lab and before publishing any data, and to complete an annual revalidation of all lines in their laboratories.

New findings published in the Proceedings of the National Academy of Sciences showed in lab studies that supplementing an epigenetic cancer drug called decitabine with vitamin C enhanced the drug's ability to impede cancer cell growth and trigger cellular self - destruction in cancer cell lines.

Even then, with a completely clean lab highly focused on meticulous technique, a new contamination struck in 2013 — something Myers identified when several different cell lines showed up with exactly the same mutation.

«Our study results suggest a new drug cocktail that is effective in both human lung cancer cell lines and fly models,» says Cagan.

In May 2005, Hwang and his colleagues reported that it had produced 11 new human embryonic stem (ES) cell lines that carried the genetic signature of patients with diabetes, spinal cord injury, or a genetic blood disorder (Science, 20 May, p. 1096).

The laboratory process, described in the journal Scientific Reports, entails genetically modifying a line of human embryonic stem cells to become fluorescent upon their differentiation to retinal ganglion cells, and then using that cell line for development of new differentiation methods and characterization of the resulting cells.

In 2001, after President Bush limited federally funded research to 69 existing embryonic stem cell lines, Melton launched a private fund - raising crusade and developed 17 new lines that are now available to any reputable stem cell researcher.

The new research shows that when the atheronals interact with various blood cells, they produce some of the effects known to lead to heart disease, such as causing a malfunction in the cells that line arterial walls.

In general, lithium alters the way calcium signals are sent and received — and the new cell lines will make it possible to study this effect specifically in bipolar disorder - specific cellIn general, lithium alters the way calcium signals are sent and received — and the new cell lines will make it possible to study this effect specifically in bipolar disorder - specific cellin bipolar disorder - specific cells.

Now, researchers in Europe report they can get new lines from «arrested» embryos — early embryos that have ceased to develop but that contain individual cells that can be induced to grow separately.

Last January, the House of Representatives voted, 253 to 174, to pass a bill, H.R. 3, that would allow researchers to use leftover embryos from in vitro fertilization (IVF) clinics to create new lines of embryonic stem cells, and in April, the Senate passed its version of the bill.

British newspapers reported this weekend that Ian Wilmut, the University of Edinburgh biologist who led the team that in 1997 cloned Dolly the sheep, is getting out of the cloning business in light of the new findings, which seem to offer researchers a likely new source of stem cell lines for basic research that could one day lead to new treatments and perhaps cures for spinal injuries, diabetes and debilitating disorders such as multiple sclerosis and Parkinson's disease.

In a new study published in Scientific Reports, Tokyo Medical and Dental University (TMDU)- led researchers investigated photodynamic detection of cancer stem cells in a glioma cell line, a model of a highly aggressive type of brain canceIn a new study published in Scientific Reports, Tokyo Medical and Dental University (TMDU)- led researchers investigated photodynamic detection of cancer stem cells in a glioma cell line, a model of a highly aggressive type of brain cancein Scientific Reports, Tokyo Medical and Dental University (TMDU)- led researchers investigated photodynamic detection of cancer stem cells in a glioma cell line, a model of a highly aggressive type of brain cancein a glioma cell line, a model of a highly aggressive type of brain cancer.

In the face of these setbacks, many scientists have focused on new methods of creating stem cell lines without destroying embryos.

Mindful of public sensitivities, Daley opted to pursue experiments using what he considers the least controversial human materials to create new nonpresidential stem cell lines — poor quality embryos and oocytes that, in his words, «otherwise would have been disposed of as medical waste.»

In May 2006, Eggan's lab received approval from Harvard to seek healthy human eggs from female donors, a first step toward using research cloning to create new stem cell lines.

The finding potentially paves the way for scores of labs to generate new stem cell lines without cloned embryos, which had long been considered the only realistic way of making human stem cells in the short run.

In a four - year study conducted on the mouse model in advanced breast cancer metastasis in the eye's anterior chamber, Petty and colleagues found that the new nanoparticle not only killed tumor cells in the eye, but also extended the survival of experimental mice bearing 4T1 tumors, a cell line that is extremely difficult to kilIn a four - year study conducted on the mouse model in advanced breast cancer metastasis in the eye's anterior chamber, Petty and colleagues found that the new nanoparticle not only killed tumor cells in the eye, but also extended the survival of experimental mice bearing 4T1 tumors, a cell line that is extremely difficult to kilin advanced breast cancer metastasis in the eye's anterior chamber, Petty and colleagues found that the new nanoparticle not only killed tumor cells in the eye, but also extended the survival of experimental mice bearing 4T1 tumors, a cell line that is extremely difficult to kilin the eye's anterior chamber, Petty and colleagues found that the new nanoparticle not only killed tumor cells in the eye, but also extended the survival of experimental mice bearing 4T1 tumors, a cell line that is extremely difficult to kilin the eye, but also extended the survival of experimental mice bearing 4T1 tumors, a cell line that is extremely difficult to kill.

They show that this new formulation reduces the minimal curative dose in a disease model, based on infections in mice, by 100-fold and, most importantly, circumvents drug resistance in a cell line that is resistant as a result of mutations in the transporter that mediates drug uptake.

A new technique of direct binding of radioactive DNA was used to screen a complementary DNA expression library from the BJAB cell line in lambda gt11 phage to derive molecular cDNA clones representing a putative B lymphocyte - specific octamer binding protein.

The toxicity of chokeberry extract on normal blood vessel lining cells was tested and found to have no effects up to the highest levels used (50 ug / ml), suggesting that the cell death effect is happening in a way other than through preventing new blood vessel formation (anti-angiogenesis), a process that is important in cancer cell growth.

In other words, APOBEC3A preempts a potential mutation by LINE - 1 jumping, by itself causing a mutation in the new LINE - 1 copy that the cell then destroyIn other words, APOBEC3A preempts a potential mutation by LINE - 1 jumping, by itself causing a mutation in the new LINE - 1 copy that the cell then destroyin the new LINE - 1 copy that the cell then destroys.

The arrangement establishes a precedent in cell line research ethics, granting Lacks a new legacy — itself a kind of immortality.

Salk scientists and colleagues have proposed new molecular criteria for judging just how close any line of laboratory - generated stem cells comes to mimicking embryonic cells seen in the very earliest stages of human development, known as naïve stem cells.

Three weeks after the scientific world marked the 20th anniversary of the birth of Dolly the sheep new research, published by The University of Nottingham, in the academic journal Nature Communications has shown that four clones derived from the same cell line — genomic copies of Dolly — reached their 8th birthdays in good health.

Cancer Research UK scientists have discovered a new line of defence used by cancer cells to evade cell death, according to research published in Nature Communications.

For now, the new stem cell lines UC Berkeley researchers have created will help scientists understand the first molecular decisions made in the early embryo.

Biologists who study the mechanics of cell division have for years disagreed about how much force is at work when the cell's molecular engines are lining chromosomes up in the cell, preparing to winch copies to opposite poles across a bridge - like structure called the kinetochore to form two new cells.

And, in the future, the potential to insert barcodes in genes and the development of in - line ID kits, that recognize specific strains of cell lines, could make it easier to verify new organisms and their protein products, and track products through supply chains.

One surprising finding from the study co-led by Johns Hopkins, Ehret says, was that many of the new sites identified were near genes that are active in cells that line the inside of blood vessels, suggesting those cells are somehow involved directly in blood pressure control.

Before dividing, pairs of identical chromosomes line up in the middle of the elongated cell, and the microtubules, emanating out from the centrioles on either side, help pull the chromosomes in opposite directions so that each new cell receives one member of each chromosome pair.

One of the gene areas identified suggests that cells within the lining of the uterus play a larger - than - expected role in the length of pregnancy, which in turn provides a new target for medications to help prevent preterm birth.

In accordance with that decision, the new guidelines would allow scientists to use NIH funds for research on cell lines isolated from embryos as long as the cells were derived by privately funded researchers who followed a set of ethical guidelines.

«This case raises new questions, since there is no precedence for consent for cell line research, and there is no precedent for requirement of consent by relatives in genome sequencing.»

In their new study, co-corresponding authors Wei Wang, PhD, professor in the departments of Chemistry and Biochemistry and Cellular and Molecular Medicine, and Gary S. Firestein, MD, professor in the Department of Medicine, investigated epigenetic patterns in fibroblast - like synoviocytes (FLS)-- a specialized type of cell that lines the inside of jointIn their new study, co-corresponding authors Wei Wang, PhD, professor in the departments of Chemistry and Biochemistry and Cellular and Molecular Medicine, and Gary S. Firestein, MD, professor in the Department of Medicine, investigated epigenetic patterns in fibroblast - like synoviocytes (FLS)-- a specialized type of cell that lines the inside of jointin the departments of Chemistry and Biochemistry and Cellular and Molecular Medicine, and Gary S. Firestein, MD, professor in the Department of Medicine, investigated epigenetic patterns in fibroblast - like synoviocytes (FLS)-- a specialized type of cell that lines the inside of jointin the Department of Medicine, investigated epigenetic patterns in fibroblast - like synoviocytes (FLS)-- a specialized type of cell that lines the inside of jointin fibroblast - like synoviocytes (FLS)-- a specialized type of cell that lines the inside of joints.

Although the 29 new mutations seemed harmless in this case, every new iPS cell line will need to be analyzed carefully before it is used to treat a patient, Izpisúa Belmonte says.

With so much work needed in studying the nature of stem cells and using them to study disease processes, therapies based on ES cells seem very far down the line, noted Lorenz Studer of Memorial Sloan - Kettering Cancer Center in New York, who pointed out that so far there have only been two published papers on therapeutic cloning, both of them in mice.

In the early 1990s, Carol Jenkins of the Papua New Guinea Institute of Medical Research developed the cell line from blood samples drawn from a member of the Hagahai tribe.

The scientists were thus able to transfer the genetic information from the known fluorescent protein eqFP615 into the DT40 chicken B cell line in order to produce protein variants of the new infrared marker Amrose with different spectral properties.

A protein secreted by cells infected with dengue virus can cause dangerous leakage of fluid from blood vessels, and new research published in PLOS Pathogens supports a primary underlying mechanism: disruption of a molecular barrier that lines the vessels.

Using a new TaqMan PCR - based technique, the researchers screened a number of cancer cell lines from various tissues, and discovered that tRNA halves were specifically expressed in large quantities in sex hormone - dependent cancers, i.e., estrogen receptor (ER)- positive breast cancer and androgen receptor (AR)- positive prostate cancer that are driven by the hormones estrogen and testosterone.

«In the future we are hopeful that BH3 - mimetics may be a valuable new line of treatment for Legionella and other bacteria that similarly hide out within cells,» Dr Vince said.