Sentences with phrase «in normal blood cells»

In most cases, these should match up, but the methylation patterns would differ in imprinted genes, where one copy would be methylated in the normal blood cells, but neither or both copies would be methylated in the disomy tissues.

UCLA researchers have found that a Chinese herbal regimen called TSY - 1 (Tianshengyuan - 1) increased telomerase activity in normal blood cells but decreased it in cancer cells.

Not exact matches

Multiple myeloma causes tumors to grow in the bone marrow, preventing the production of normal blood cells.

The overgrowth of promyelocytes leads to a shortage of normal white and red blood cells and platelets in the body, which causes many of the signs and symptoms of the condition.

In addition, affected individuals may heal slowly from injuries or have frequent infections due to the loss of normal white blood cells that fight infection.

It's normal for the red blood cells to break down, although the bilirubin formed doesn't normally cause jaundice because the liver will metabolize it and then get rid of it in the gut.

This is jaundice and is caused by a normal breakdown of old red blood cells resulting in an increased amount of bilirubin.

Other kinds of congenital anomalies that are sometimes found with this condition are, as previously mentioned, Down Syndrome, shorter intestines than normal, lower birth weight, and an imbalance of electrolytes, which are the elements in the blood, tissue and cell fluid needed to help the person balance their energy.

Jaundice happens when too much bilirubin — a chemical that red blood cells release during their normal breakdown process — builds up in the blood.

Cancer cells can break away from a primary tumor, penetrate into lymphatic and blood vessels, circulate through the bloodstream, and grow in a distant focus (metastasize) in normal tissues elsewhere in the body.

Of course the immune cells in the pregnant scientist's blood had stopped behaving «normally»: the immune system in pregnancy is anything but normal.

Finally, it could be shown that low regulatory T - cell numbers in umbilical cord blood was an indication that children exposed to tobacco smoke were more likely to develop an allergy before the age of three compared to those children with normal values for miR - 223 and Treg cells.

In contrast, the corrected cells live the length of normal red blood cells, about 120 days.

Using a mathematical model known as the Ising model, invented to describe phase transitions in statistical physics, such as how a substance changes from liquid to gas, the Johns Hopkins researchers calculated the probability distribution of methylation along the genome in several different human cell types, including normal and cancerous colon, lung and liver cells, as well as brain, skin, blood and embryonic stem cells.

Cells engineered to produce insulin under the command of a smartphone helped keep blood sugar levels within normal limits in diabetic mice, a new study reports.

The metabolism of bone cells determines how much sugar they use; if the bone cells consume more sugar than normal, this can lower the glucose level in the blood.

In experiments on normal and MLL cells from mice and humans, the researchers demonstrated that beta - catenin is activated in cancer stem cells that prompt leukaemic blood cells to multiplIn experiments on normal and MLL cells from mice and humans, the researchers demonstrated that beta - catenin is activated in cancer stem cells that prompt leukaemic blood cells to multiplin cancer stem cells that prompt leukaemic blood cells to multiply.

However, when the researchers corrected the genetic defect that causes DBA, the iPSCs developed into red blood cells in normal quantities.

Because HIF signals cells to produce VEGF, the researchers wondered whether deleting HIF in amacrine and horizontal cells would also stop the pipeline of VEGF and normal intermediate layer blood vessel development.

In DBA, a mutation prevents a patient's bone marrow from producing normal quantities of red blood cells, resulting in severe, sometimes life - threatening anemiIn DBA, a mutation prevents a patient's bone marrow from producing normal quantities of red blood cells, resulting in severe, sometimes life - threatening anemiin severe, sometimes life - threatening anemia.

The researchers have now reported in the journal Nature that the normal process of blood formation differs from what scientists had previously assumed when using data from stem cell transplantations.

In another experiment, the research team transferred infection - combatting white blood cells — called neutrophils — from normal mice to genetically mutated mice.

«The effect of the precursors that boost NAD is to counteract the decline that occurs with normal aging, to reactivate SIRT1, and to restore function in endothelial cells to give rise to more blood vessels.»

The most striking abnormalities were a markedly elevated white blood cell count of 28,500 per cubic milliliter (the normal level is about 5,000 to 10,000) and what is called a shift to the left, which refers to a large increase in the number of mature and immature granulocytes, cells that increase in number when an acute infection must be fought off.

Moreover, mice engineered to generate smaller than normal quantities of SIRT1 carried relatively little fat in their blood, indicating that their cells hung onto it.

Diabetes results from too few insulin - producing «beta cells» in the pancreas secreting too little insulin, the hormone required to keep blood sugar levels in the normal range.

The normal function of RIPK2 is to send warning signals to cells that bacterial infection has occurred, which in turn spurs the body to mobilize white blood cells.

They showed that stress in pancreatic cells due to sleep deprivation may contribute to the loss or dysfunction of these cells important to maintaining proper blood sugar levels, and that these functions may be exacerbated by normal aging.

Then they would transfuse donor bone marrow rich in the highly prized stem cells that are capable of generating new, normal blood.

«Under normal circumstances, blood clot contraction plays an important role in preventing bleeding by making a better seal, since the cells become tightly packed as the spaces between them are eliminated,» Weisel said.

In experiments with genetically engineered mice that lacked beta cells, reprogrammed stomach cells pumped out insulin and glucose at normal levels in the blooIn experiments with genetically engineered mice that lacked beta cells, reprogrammed stomach cells pumped out insulin and glucose at normal levels in the blooin the blood.

The researchers found that the anti-cancer drug romidepsin increased the virus production in HIV - infected cells between 2.1 and 3.9 times above normal and that the viral load in the blood increased to measurable levels in five out of six patients with HIV infection.

Everybody has suPAR, which is produced by bone marrow cells, in their blood, with normal levels around 2400 picogram per milliliter (pg / ml).

Interestingly, the outbreak strain grew at a normal pace in cultured human white blood cells, apparently by subverting the immune response to its benefit.

A study published January 4th in Cell Stem Cell demonstrates that a gene therapy approach can lead to the long - term survival of functional beta cells as well as normal blood glucose levels for an extended period of time in mice with diabetes.

The toxicity of chokeberry extract on normal blood vessel lining cells was tested and found to have no effects up to the highest levels used (50 ug / ml), suggesting that the cell death effect is happening in a way other than through preventing new blood vessel formation (anti-angiogenesis), a process that is important in cancer cell growth.

The five - year study, led by UCLA Jonsson Comprehensive Cancer Center member Dr. Jianyu Rao, measured the ability of TSY - 1 to affect telomerase activity in cancer cells lines, including one known as HL - 60, as well as normal peripheral blood mononuclear and hematopoietic stem cells.

«This technology allows for the labeling of just one circulating pathological cell among billions of other normal blood cells by ultrafast changing color of photosensitive proteins inside the cell in response to laser light,» explains Dr. Galanzha.

A form of non-Hodgkin lymphoma, follicular lymphoma develops when the body starts making abnormal B - cells, which are white blood cells that in normal conditions fight infections.

This inflammation is important in the normal healing process, affecting tissue growth and blood flow changes that allow the tissue to heal; when the inflammation subsides, skin cells start growing to cover the wound and help the tissue knit together.

«ECPR and a factor in the blood called protein C act as a «brake» on blood coagulation and endothelial cell inflammation and also enhance the viability and integrity of blood vessels, but when the malaria parasites use PfEMP1 to bind EPCR, they may interfere with the normal function of EPCR, and thus the binding can be the catalyst for the violent reaction,» he explains.

«Under normal conditions, ECPR plays a crucial role in regulating blood clotting, inflammation, cell death and the permeability of blood vessels.

In 2008, researchers led by YongKeun Park and Monica Diez - Silva of the Massachusetts Institute of Technology found that red blood cells vibrated less when they were infected with the malaria parasite, apparently because the infection made the cells stiffer than normal (Proceedings of the National Academy of Sciences, DOI: 10.1073 / pnas.0806100105).

Compared with normal chow diet - fed mice, the high - fat diet mice showed worsened blood sugar, increased triglycerides, a type of fat (lipid) in the blood, and a substantial increase in the numbers of CD8 + T cells in the liver.

The researchers found that in genetically - modified mice lacking Interferon - 1, who were also fed a high - fat diet, the CD8 + T cells did not produce an inflammatory response, and the mice had near normal blood sugar levels.

Normal red blood cells are about 8 microns in size, but can circulate in the microvascular system with a diameter of 1 to 2 microns because they are flexible, deformable and durable.

In laboratory experiments, malignant white blood cells and primary cells from autoimmune disease patients have been shown to be much more sensitive to Leukothera than their normal counterparts.

When blasted with 10 Gy of irradiation — enough to wipe out all blood stem cells in the bone marrow of normal mice — mutant mice that were unable to fully activate p53 experienced only a modest blood count drop.

Quantification of cellular volume and sub-cellular density fluctuations: comparison of normal peripheral blood cells and circulating tumor cells identified in a breast cancer patient.

(5 - azacytidine, Vidaza) A demethylating agent, this medicine interacts with DNA to restore normal growth of blood cells in the bone marrow.