Sentences with phrase «in normal brain function»

Finally, we generate new tools and mouse models to study the role of de novo protein synthesis in normal brain function and in pathophysiology associated with neurodevelopmental and neurodegenerative disease.

Many of the insertion sites were located within genes that play key roles in normal brain function.

Altogether, scientific evidence suggests that all features of the near - death experience have some basis in normal brain function gone awry.

«We believe estradiol, a form of estrogen, is very important in normal brain function, specifically in the pre-frontal cortex, which regulates executive function — organization, recall, memory and other cognitive functions,» Epperson says.

Although the work is done in the context of a more general problem — the effect of environmental electromagnetic fields upon cellular functions — Adey is also concerned with the question of how brain waves might play a role in normal brain function.

A major target of such poor development is the gut and thus any abnormality in gut nerve development (the gut contains more neurones than the spinal cord) would have a significant effect not only on gut functions and probably gut microbiome, but also on information flowing back to the brain that may cause interference in normal brain functions, perhaps precipitating ASD - like behaviour in a developmentally challenged brain.

Not exact matches

If we could but restore or bring about the normal functioning of brain cells and nerve tissues, as well as their own subsidiary chemical activity in such cases, then mental life would come flooding back in fullness and richness.

B6 is therefore needed for normal brain development and function, and helps to make the hormones serotonin and norepinephrine, which influence mood; and melatonin, which helps to keep your body clock in top order.

According to the University of Maryland Medical Center polyunsaturated fatty acids (PUFAs)-- also known as omega - 3 fatty acids — play a crucial role in human brain function, as well as normal growth and development, with research showing that they can also reduce inflammation in addition to helping lower the risk of chronic diseases such as heart disease, cancer, and arthritis.

In addition, too much water will disturb the normal balance of electrolytes in their bodies and can affect brain and heart functioIn addition, too much water will disturb the normal balance of electrolytes in their bodies and can affect brain and heart functioin their bodies and can affect brain and heart function.

Choline which helps in maintaining normal brain development is important for babies muscle and nerve function and healthy metabolism.

Specifically, intensive postmortem neurological studies of their brain tissues reveal a relatively low density of acetylcholine (a neurotransmitter) nerve sites, which, at normal densities, function in critical ways to help re-initiate breathing following a sleep - related apnea or extended breathing pauses.

The study also discovered that microscopic spasms in capillaries occur, albeit with lower frequency, during normal brain function, too, suggesting that one problem caused by epilepsy is that seizures drive these vasospasms to abnormal levels.

Delirium is a clinical syndrome caused by a disturbance in the normal functioning of the brain.

«By exploring normal brain function, we can better understand what happens in someone with a mental illness.»

This sensation of pain was previously thought to be caused by abnormal plasticity in the sensorimotor cortex of the brain, and rehabilitative therapies have focused on restoring normal motor function to relieve the pain.

Prions, whose normal function is unclear, are the likely cause of mad cow disease and similar brain disorders in animals and humans.

Using a technique called nuclear magnetic resonance spectroscopy, the researchers measured the concentrations of 21 metabolites key to nerve function in the brains of 10 deceased schizophrenia patients and 12 normal human controls.

Until the last few decades, the frontal lobes of the brain were shrouded in mystery and erroneously thought of as nonessential for normal function — hence the frequent use of lobotomies in the early 20th century to treat psychiatric disorders.

«It was particularly exciting to see plasticity in the neurons impaired by mHTT,» said Davidson, noting that in the HD mice, brain areas that had begun to atrophy recovered volume and permitted better motor function after the researchers restored mTORC1 activity to more normal levels.

Even among people of normal weight, individual differences in brain functioning can directly affect eating behaviors, according to a 2009 study by Michael Lowe, a research psychologist at Drexel University.

In the absence of pain, morphine interferes with normal body function and is viewed as a pathogen, activating the brain's innate immune cells and causing the release of inflammatory chemicals such as cytokines.

Much work remains in optimizing how faithfully the bits of tissue reproduce normal brain function and architecture, Panchision says.

Previous evidence has shown that TGF β1, a molecule associated with essential functions in nervous system development and repair, modulates other components responsible for normal brain function.

The findings, published in the journal Nature Neuroscience, could help explain how some older adults with beta - amyloid deposits in their brain retain normal cognitive function while others develop dementia.

During the study of a number of aardvarks by researchers of the Brain Function Research Group at the University of the Witwatersrand, all but one of the study animals — as well as other aardvarks in the area — died because of a severe drought, with air temperatures much higher than normal and very dry soil in the area.

The study supports the importance of the serotonin which is specified and maintained by a specific gene, the Pet - 1 gene — for normal functioning of the neurons, synapses and networks in the cortex, as well as proper development of brain circuitry.

The National Institutes of Health (NIH) in Bethesda, Maryland, has confirmed that the agency's definition of clinical trials now includes imaging studies of normal brain function that do not test new treatments.

«We hope that in the future, by fully understanding how this gene affects signaling in the brain, we may be able to identify drugs to restore the normal signaling balance in neurons and improve cognitive and social function in patients,» says lead author Dr. M. Chiara Manzini.

C1q also plays a positive role in the brain by clearing out dead cells and helping target harmful materials, so learning how to manipulate its presence to prevent debilitating synapse loss while maintaining its normal functions will require further research.

DHA in brain and retinal cells also builds reservoirs for molecules called into action when normal functions are disrupted, resulting in such conditions as retinal degeneration, Parkinson's or Alzheimer's disease.

Mobile DNA molecules that jump from one location in the genome to another may contribute to neurological diseases and could have subtle influences on normal brain function and behavior, according to a study published October 30 in Nature.

«That likely leads to aberrant brain function or impairments in the normal computations of the brain,» he said.

The ultimate goal is to better understand how the billions of neurons in the brain communicate with one another during normal brain function, or dysfunction, as result of injury or disease.

One even showed greater dopamine activity in the injured side of the brain than on the normal side, indicating, says Jaenisch, that «these IPS cells could be used also for generating function of dopaminergic neurons that could have therapeutic value.»

Recent large - scale efforts have launched a new generation of studies that aim to identify the molecular and cellular characteristics of the brain and how these translate into normal brain function — or, in the case of disease, dysfunction.

This brain lipid is indispensable for normal function, but its overabundance causes neurodegeneration, resulting in severe neurological symptoms.

Health improvement (allowing to post - pone / escape the diseases and thus live, healthier / disease - free longer, but not above human MLSP of around 122 years; thus these therapies do not affect epigenetic aging whatsoever, they are degenerative aging problems not regular healthy aging problem (except OncoSENS - only when you Already Have Cancer - which cancer increases epigenetic aging, but cancer removal thus does not change anything / makes no difference about what happens in the other cells / about what happens in the normal epigenetic «aging» course in Normal non-cancerous healthy cells) Although there is not such thing as «healthy aging» all aging in «unhealthy» (as seen from elders who are «healthy enough» who show much damage), it's just «tolerable / liveable» enough (in terms of damage accumulating) that it does not affect their quality of life (enough yet), that is «healthy aging»: ApoptoSENS - Clearing Senescent Cells (this will have great impact to reduce diseases, the largest one, since it's all inflammation fueled by the inflammation secretory phenotype (SASP) of these senescent cells) AmyloSENS - Dissolving the Plaques (this will allow humans to evade Alzheimer's, Parkinsons and general brain degenerescence, allowing quite a boost; making people much more easily reach the big 100 - since the brain is causal to how long we live; keeping brain amyloid - free and keeping our memories / neuron sharp / means longer LongTerm Potentiation - means longer brain function means longer heavy brain mass (gray matter / white matter retention seen in «sharp - witted» Centenarians who show are younger brain for their age), and both are correlated to normal epigenetic «aging» course in Normal non-cancerous healthy cells) Although there is not such thing as «healthy aging» all aging in «unhealthy» (as seen from elders who are «healthy enough» who show much damage), it's just «tolerable / liveable» enough (in terms of damage accumulating) that it does not affect their quality of life (enough yet), that is «healthy aging»: ApoptoSENS - Clearing Senescent Cells (this will have great impact to reduce diseases, the largest one, since it's all inflammation fueled by the inflammation secretory phenotype (SASP) of these senescent cells) AmyloSENS - Dissolving the Plaques (this will allow humans to evade Alzheimer's, Parkinsons and general brain degenerescence, allowing quite a boost; making people much more easily reach the big 100 - since the brain is causal to how long we live; keeping brain amyloid - free and keeping our memories / neuron sharp / means longer LongTerm Potentiation - means longer brain function means longer heavy brain mass (gray matter / white matter retention seen in «sharp - witted» Centenarians who show are younger brain for their age), and both are correlated to Normal non-cancerous healthy cells) Although there is not such thing as «healthy aging» all aging in «unhealthy» (as seen from elders who are «healthy enough» who show much damage), it's just «tolerable / liveable» enough (in terms of damage accumulating) that it does not affect their quality of life (enough yet), that is «healthy aging»: ApoptoSENS - Clearing Senescent Cells (this will have great impact to reduce diseases, the largest one, since it's all inflammation fueled by the inflammation secretory phenotype (SASP) of these senescent cells) AmyloSENS - Dissolving the Plaques (this will allow humans to evade Alzheimer's, Parkinsons and general brain degenerescence, allowing quite a boost; making people much more easily reach the big 100 - since the brain is causal to how long we live; keeping brain amyloid - free and keeping our memories / neuron sharp / means longer LongTerm Potentiation - means longer brain function means longer heavy brain mass (gray matter / white matter retention seen in «sharp - witted» Centenarians who show are younger brain for their age), and both are correlated to MLSP).

BDNF, a target gene of CREB, is reduced with age and in the AD brain [112] and is required for normal cognitive function [113].

With this tool, neuroscientists can use light to trigger or suppress neuronal firing and precisely manipulate animal behavior, allowing them to map circuits underlying normal brain functions and study their dysfunction in mood and movement disorders.

We find that if neurogenesis occurs in the adult hippocampus in humans, it is an extremely rare phenomenon, raising questions about its contribution to brain repair or normal brain function.

The Center for Integrative and Cognitive Neuroscience, directed by Jeffrey Schall, helps form and support alliances of investigators interested in studying how normal and abnormal behavior and cognition arise from the function of the brain.

Today, researchers in the laboratory of Gladstone Senior Investigator Lennart Mucke, MD, report in Nature Neuroscience that DSBs in neuronal cells in the brain can also be part of normal brain functions such as learning — as long as the DSBs are tightly controlled and repaired in good time.

A balance of excitatory and inhibitory activity in the brain is essential for normal function.

In addition to the risk of second cancers decades later, radiation to growing bones and organs could impede normal development, and radiation to the brain, a common site of pediatric cancers, often resulted in impairments to learning and other cognitive brain functionIn addition to the risk of second cancers decades later, radiation to growing bones and organs could impede normal development, and radiation to the brain, a common site of pediatric cancers, often resulted in impairments to learning and other cognitive brain functionin impairments to learning and other cognitive brain functions.

Plus, there are other drugs being developed and tested that aim to slow or prevent HD in other ways, by helping restore normal functioning of the brain in the presence of the mutant huntingtin protein.

Such changes in neuronal function are likely to play important roles in all normal physiological processes in the brain and are critical for development of a variety of brain diseases, including Alzheimer's disease, Parkinson's disease, schizophrenia, epilepsy, drug dependence and other neurological and psychiatric disorders.

As brain tumors grow, they can cause a wide array of challenging symptoms for patients due to pressure in the brain and / or interference with normal brain function.

«This work has great potential to crack open the «black box» of how neuropeptides, including oxytocin, function in normal and aging brains,» said Verdin.

What your brain actually starts to think is that you've found yourself in a situation where it's impossible to get more calories to sustain normal body functioning, so it begins to preserve energy because it thinks you're starving.