Sentences with phrase «in normal breast cells»

:: Washington Post Bisphenol A can alter genes, study finds Bisphenol A, the widely used compound in polycarbonate plastic, has the ability to alter the activity of genes in normal breast cells in ways that resemble what is found in extremely dangerous breast cancers, according to a new study.

They found that the protein seems to help maintain several traits in normal breast cells, including the ability to adhere to other epithelial cells, and the presence of molecules marking the cells as differentiated and not capable of self - renewal like breast stem cells.

Now, results of a new study by Johns Hopkins Kimmel Cancer Center scientists suggests a powerful role for the protein in normal breast cells, acting as a tumor suppressor that halts abnormal cell growth.

Not exact matches

Their study, reported in the journal PLoS Computational Biology, suggests that breast feeding not only taps the normal brain cells involved in secreting oxytocin.

Working with human breast tissue, the new study's authors attempted to induce EMT in normal cells; they figured they would just get fibroblasts, a type of connective tissue that is important in wound healing.

In subsequent experiments, the Einstein team deciphered other parts of the Rac1 signaling cascade during invasion and showed that this signaling mechanism is regulated differently in normal breast epithelial cellIn subsequent experiments, the Einstein team deciphered other parts of the Rac1 signaling cascade during invasion and showed that this signaling mechanism is regulated differently in normal breast epithelial cellin normal breast epithelial cells.

«Perhaps there are some mammary gland stem cells that can be coaxed to have a slightly broader potential than normal, but I very much doubt that embryonic - like cells normally exist in the breast,» says Robin Lovell - Badge of the National Institute for Medical Research in London.

Being obese or having a higher body mass index (BMI) while carrying a BRCA (BReast CAncer gene) mutation is positively linked with higher levels of damage to the DNA in normal breast gland cells, new research sugBReast CAncer gene) mutation is positively linked with higher levels of damage to the DNA in normal breast gland cells, new research sugbreast gland cells, new research suggests.

Plakoglobin is a component of two important structures involved in cell - to - cell adhesion, and the investigators found that suppressing its expression caused CTC clusters to fall apart, reducing their metastatic potential, and also disrupted cell - to - cell contact between breast cancer cells but not normal breast tissue.

In addition to using normal breast cancer cells in the experiments, the team also used cancer cells that had been genetically engineered to lack either GSTO1 or RYRIn addition to using normal breast cancer cells in the experiments, the team also used cancer cells that had been genetically engineered to lack either GSTO1 or RYRin the experiments, the team also used cancer cells that had been genetically engineered to lack either GSTO1 or RYR1.

First author Adam Skibinski, M.D. / Ph.D., student at Tufts University School of Medicine and the Sackler School of Graduate Biomedical Sciences at Tufts University, said «We've known for a long time that breast cells can lose their normal identity when they become cancerous, but we are now realizing that normal cells can change their characteristics as well in response to transcription factors like TAZ.

«Breast cancer researchers track changes in normal mammary duct cells leading to disease.»

Breast cancer researchers have mapped early genetic alterations in normal - looking cells at various distances from primary tumours to show how changes along the lining of mammary ducts can lead to disease.

In this most recent study, the researchers analyzed the various mechanical changes to breast cancer cells in which myoferlin levels were dramatically reduced compared to normal breast cancer cellIn this most recent study, the researchers analyzed the various mechanical changes to breast cancer cells in which myoferlin levels were dramatically reduced compared to normal breast cancer cellin which myoferlin levels were dramatically reduced compared to normal breast cancer cells.

By manipulating it in vitro, a team of researchers led by Prof. David Mooney at Harvard SEAS have identified a possible mechanism by which normal cells turn malignant in mammary epithelial tissues, the tissues frequently involved in breast cancer.

In their study published online May 9 in the journal Oncogene, scientist Saraswati Sukumar, Ph.D.; her graduate student Wei Wen Teo; and their colleagues show that cells without HOXA5 have an increased capacity to renew themselves and are more invasive than normal breast cells — in short, they become more tumor likIn their study published online May 9 in the journal Oncogene, scientist Saraswati Sukumar, Ph.D.; her graduate student Wei Wen Teo; and their colleagues show that cells without HOXA5 have an increased capacity to renew themselves and are more invasive than normal breast cells — in short, they become more tumor likin the journal Oncogene, scientist Saraswati Sukumar, Ph.D.; her graduate student Wei Wen Teo; and their colleagues show that cells without HOXA5 have an increased capacity to renew themselves and are more invasive than normal breast cells — in short, they become more tumor likin short, they become more tumor like.

Since a protein called Rac1 is essential for normal milk production, as well as phagocytosis in immune cells, Nasreen Akhtar at the University of Sheffield and her colleagues wondered whether it might also be involved in this breast remodelling.

The researchers identified a protein, SOCS3, that is highly expressed in normal cells but undetectable in triple - negative breast cancer.

The research, using cells from the Breast Cancer Now Tissue Bank and due to be published in Nature Communications, also shows that the epigenetic changes are inherited as long as the cell divides, and that the team's manipulations permanently and negatively affected the biology of a normal breast cell from a healthy indivBreast Cancer Now Tissue Bank and due to be published in Nature Communications, also shows that the epigenetic changes are inherited as long as the cell divides, and that the team's manipulations permanently and negatively affected the biology of a normal breast cell from a healthy indivbreast cell from a healthy individual.

Dr. David Gilley's laboratory at the Indiana University School of Medicine in Indianapolis and Dr. Connie Eaves» laboratory at the BC Cancer Agency's Terry Fox Laboratory in Vancouver, Canada, collaborated to determine how telomeres are regulated in different types of normal breast cells.

The researchers inserted between 10,000 and 40,000 of these small RNAs at once into breast cancer, colon cancer, and normal human cells in the lab.

Assistant Professor Camila dos Santos of Cold Spring Harbor Laboratory (CSHL) is studying stem cells in the breast for clues about what changes occur when normal breast cells become cancerous.

Quantification of cellular volume and sub-cellular density fluctuations: comparison of normal peripheral blood cells and circulating tumor cells identified in a breast cancer patient.

Cancer stem cell markers are enriched in normal tissue adjacent to triple negative breast cancer and inversely correlated with DNA repair deficiency.

December 20, 2007 Genetic alterations in the benign - appearing stromal cells surrounding breast cancers predict for nodal metastases The cells surrounding breast cancers, called stroma, are benign appearing, «normal» by all accounts.

Using cutting - edge techniques enabled by next - generation sequencing, the authors generated complete methylome maps at single nucleotide resolution in a low - passage breast cancer cell line and normal breast tissue (primary human mammary epithelial cells).

It has been reported that human breast CSCs and normal human mammary stem / progenitor cells showed decreased expression of miR200c and other miR200 members and that restoring miR200c in breast CSCs inhibits their ability to expand clonally and form tumors in vivo [38].

Researchers have identified cellular changes that may play a role in converting normal breast cells into tumors...

I had a hunch based on this work that microRNA expression would be different in breast cancer stem cells than in more differentiated tumor cells or normal tissue and that it would change as the stem cells differentiated to form a tumor.

Both normal and cancer breast stem cells give rise to 3D mammospheres in suspension culture.

In the breast, cancer stem cells and normal stem cells can arise from different cell types and tap into distinct yet related stem cell programs, according to Whitehead Institute researchers.

Cambridge, Mass. — June 16, 2014 — A team of researchers led by David J. Mooney, Robert P. Pinkas Family Professor of Bioengineering at the Harvard School of Engineering and Applied Sciences (SEAS), have identified a possible mechanism by which normal cells turn malignant in mammary epithelial tissues, the tissues frequently involved in breast cancer.

Lauric Acid inhibited the viability of both cancer cell types without altering the growth of MCF - 10A normal breast epithelial cells, thus suggesting its specific potential to trigger antiproliferative effects in malignant cells.

The study found that curcumin is able to induce apoptosis (normal programmed cell death) in the most resistant breast cancer cells that lack estrogen receptors.