Sentences with phrase «in normal breast tissue»

Mammary tumor virus sequences have not been detected in normal breast tissue or other tumors.

(A) MELK expression levels are significantly higher in breast carcinoma (n = 392, red circles) than in normal breast tissues (n = 61, blue circles) in the TCGA breast cancer cohort (Cancer Genome Atlas Network, 2012).

Not exact matches

In most boys the breast tissue growth is temporary and will shrink back to normal size.

In some cases, a girl's breasts may grow during puberty, but perhaps that growth is asymmetrical (uneven) or the breasts are large and appear normal, but only fatty tissue develops, not glandular tissue.

Working with human breast tissue, the new study's authors attempted to induce EMT in normal cells; they figured they would just get fibroblasts, a type of connective tissue that is important in wound healing.

Plakoglobin is a component of two important structures involved in cell - to - cell adhesion, and the investigators found that suppressing its expression caused CTC clusters to fall apart, reducing their metastatic potential, and also disrupted cell - to - cell contact between breast cancer cells but not normal breast tissue.

Their research, published in PLOS ONE, focused on one particular gene — TRIM29 — selected from a pool of 100 genes with regulatory patterns specific to normal breast tissue, to prove the link between breast - specific genes and the pathology of cancer.

In this particular case, the researchers used DESI mass spectrometry imaging to look at the distribution and amounts of fatty acid substances, called lipids, within breast tissue and normal tissue from 61 samples obtained from 14 breast cancer patients that underwent mastectomy.

The researchers found that several fatty acids, such as oleic acid, were more abundant in breast cancer tissue compared to normal tissue.

By manipulating it in vitro, a team of researchers led by Prof. David Mooney at Harvard SEAS have identified a possible mechanism by which normal cells turn malignant in mammary epithelial tissues, the tissues frequently involved in breast cancer.

They showed that the iKnife could distinguish normal and tumor tissues from different organs, such as breast, liver, and brain, and could even identify the origin of a tumor that was a metastasis, a secondary growth seeded by a primary tumor elsewhere in the body.

The research, using cells from the Breast Cancer Now Tissue Bank and due to be published in Nature Communications, also shows that the epigenetic changes are inherited as long as the cell divides, and that the team's manipulations permanently and negatively affected the biology of a normal breast cell from a healthy indivBreast Cancer Now Tissue Bank and due to be published in Nature Communications, also shows that the epigenetic changes are inherited as long as the cell divides, and that the team's manipulations permanently and negatively affected the biology of a normal breast cell from a healthy indivbreast cell from a healthy individual.

Interestingly, the team found that radiologists could do better than chance in discriminating breast cancer cases from normal tissue, even when the images of abnormal breast tissue did not directly capture a cancerous lesion or when those images were taken from the contralateral breast (the breast on the other side of the body) of a woman with breast cancer.

Cancer stem cell markers are enriched in normal tissue adjacent to triple negative breast cancer and inversely correlated with DNA repair deficiency.

Using cutting - edge techniques enabled by next - generation sequencing, the authors generated complete methylome maps at single nucleotide resolution in a low - passage breast cancer cell line and normal breast tissue (primary human mammary epithelial cells).

Immunohistochemical results revealed higher expression of Cyclin D1 in IDC comparing to normal and benign breast tissues.

Rudensky's team compared Tregs in normal human breast tissues with those found in untreated breast tumors, and found that Tregs in tumors were capable of more potent and aggressive immunosuppressive action.

Tissue specimens were obtained from 30 cases having IDC and from 10 cases were diagnosed with benign breast lesions in addition to 10 normal breast samples were taken from tissue adjacent to the tTissue specimens were obtained from 30 cases having IDC and from 10 cases were diagnosed with benign breast lesions in addition to 10 normal breast samples were taken from tissue adjacent to the ttissue adjacent to the tumors.

Inclusion Criteria: • Availability of tumor tissue for mesothelin expression testing • Histologically - confirmed, mesothelin - expressing metastatic or advanced non-metastatic disease (tumour type specific inclusion criteria) • At least one measurable lesion according to either Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 or International Thymic Malignancy Interest Group (ITMIG) modified RECIST 1.1 as applicable • Adequate bone marrow, liver, renal and coagulation function • Left ventricular ejection fraction (LVEF) ≥ 50 % of the lower limit of normal (LLN) according to local institutional ranges • Eastern Cooperative Oncology Group (ECOG) 0 or 1 Exclusion Criteria: • More than one prior anti - tubulin / microtubule agent • Corneal epitheliopathy or any eye disorder that may predispose the patients to this condition • Symptomatic Central nervous system (CNS) metastases and / or carcinomatous meningitis • Contraindication to both CT and MRI contrast agents • Active hepatitis B or C infection • Pregnant or breast - feeding patients • Tumor type specific exclusion criteria

I had a hunch based on this work that microRNA expression would be different in breast cancer stem cells than in more differentiated tumor cells or normal tissue and that it would change as the stem cells differentiated to form a tumor.

Our bioinformatics analysis, based on multiple independent large - size cohorts shows that MELK is strongly overexpessed in BBC / TNBC, not only compared to normal breast tissues, but also compared to luminal or ER / PR + breast cancer.

Cambridge, Mass. — June 16, 2014 — A team of researchers led by David J. Mooney, Robert P. Pinkas Family Professor of Bioengineering at the Harvard School of Engineering and Applied Sciences (SEAS), have identified a possible mechanism by which normal cells turn malignant in mammary epithelial tissues, the tissues frequently involved in breast cancer.

If you're wondering what a cancer lump feels like, know that most of the time lumps are not cancer — in fact, normal breast tissue can feel lumpy too.

Some of the symptoms you might see with estradiol levels elevated above normal lab reference ranges (or sometimes even with «high normal» levels) are: fluid retention, mood swings, nipple sensitivity / breast tissue stimulation, bloating, hot flashes and, reduction in clinical benefit from TRT.

Tamoxifen and flaxseed alter angiogenesis regulators in normal human breast tissue in vivo.