Sentences with phrase «in normal cell growth»

Not exact matches

In earlier work, Paller's lab had discovered that depleting an enzyme called GM3 synthase made cells particularly sensitive to growth factors and led to normal wound healing despite diabetic conditions.

Finally, they used a technique called genetic ablation to kill the amacrine cells and horizontal cells altogether and found this resulted in a lack of normal vessel growth in the intermediate layer.

In normal bone development, the shaft matures and ceases growth (cell division) long before the ends do.

Auxin controls a range of responses in plants, including cell and tissue growth and normal development.

«Tumor cells produce larger quantities of H2O2 and use oxidative signals at higher levels than normal cells in order to drive their own growth,» says Mirko Sobotta, first author of the publication.

In a healthy mother, this enzyme is activated by hormones like insulin and insulin - growth factors (IGFs), kick - starting a relay race within cells which stimulates nutrient uptake and, as a result, normal growth and metabolic function.

However, cancer cells may instead be coaxed to turn back into normal tissue simply by reactivating a single gene, according to a study that found that restoring normal levels of a human colorectal cancer gene in mice stopped tumor growth and re-established normal intestinal function within only 4 days.

In normal cell function messenger chemicals, such as various growth factors and insulin, bind to protein receptors on the cell's surface.

In addition to its known roles in cancerous cells, STAT3 also is an essential mediator of cytokine and growth factor signals in normal cells that are important for diverse processes including immunity and inflammatioIn addition to its known roles in cancerous cells, STAT3 also is an essential mediator of cytokine and growth factor signals in normal cells that are important for diverse processes including immunity and inflammatioin cancerous cells, STAT3 also is an essential mediator of cytokine and growth factor signals in normal cells that are important for diverse processes including immunity and inflammatioin normal cells that are important for diverse processes including immunity and inflammation.

A study by Mo's group in a 2011 issue of Experimental Biology and Medicine (236:604 - 613) showed that normal fibroblasts are 10-fold more resistant than murine B16 melanoma cells to geranylgeraniol - mediated growth suppression.

In fact, associations of cancer cells with the normal peritumoral microenvironment can profoundly impact tumor growth and development.

Her research has recently shown that a signaling pathway dubbed «hedgehog» is important not only for normal development of stem cells but also for the growth of cancer cells in chronic myelogenous leukemia.

They found that normal cells grow faster when in an organoid with cells expressing RasG12V at low levels, but required more than one mutant cell to kick - start this abnormal growth.

The toxicity of chokeberry extract on normal blood vessel lining cells was tested and found to have no effects up to the highest levels used (50 ug / ml), suggesting that the cell death effect is happening in a way other than through preventing new blood vessel formation (anti-angiogenesis), a process that is important in cancer cell growth.

Now, results of a new study by Johns Hopkins Kimmel Cancer Center scientists suggests a powerful role for the protein in normal breast cells, acting as a tumor suppressor that halts abnormal cell growth.

This inflammation is important in the normal healing process, affecting tissue growth and blood flow changes that allow the tissue to heal; when the inflammation subsides, skin cells start growing to cover the wound and help the tissue knit together.

Working with Bhaduri, who has a background in statistics and bioinformatics, Pollen and Nowakowski began exploring how specific classes of neurons and stem cells in the developing brain contribute to normal brain growth as well as to neurodevelopmental disease, and have begun to build a comprehensive, open - source atlas of gene expression across the developing brain, which they hope will serve as a resource for other scientists.

«We have identified a number of pharmaceutical compounds that selectively inhibit — in different experimental models — the mitochondrial enzyme responsible for the tumour growth, thus limiting fat synthesis and without harming normal cells.»

Zinc is the second most abundant trace metal in the human body (next to calcium) and an essential dietary nutrient that's crucial for normal cell growth, a strong immune system and healthy nerve function — to name just a few of its widespread influences.

The researchers discovered that the activity of this electric signal is necessary in different aspects of normal regeneration, namely for the expression of crucial genes, formation of a mass of cells capable of growth and regenerate, and proper tissue innervation.

He notes, however, that other attempts to stimulate bone growth in mice by manipulating cell signaling proteins have produced denser than normal bones — and he's surprised that Helms's team didn't see the same.

We're manipulating genes in the cell nucleus to produce specific proteins, changing the normal recipe for growth and maturation, and transforming adult cells into a new type of cell with the ability to morph into any other cell type,» said Cooke, senior author and chair of the Department of Cardiovascular Sciences.

This protein is essential for the growth of normal cells, but is hyperactive in tumor cells.

Human transforming growth factor - beta complementary DNA sequence and expression in normal and transformed cells.

These include, for example, the mechanisms behind stem - cell development and what happens when normal cellular growth spirals out of control, such as in cancer.

With the award - winning work, Sebastian Zeißig's group demonstrated that bacteria within the normal gut microbiota can invade the intestinal tissue and activate an enzyme in stem cells that facilitates stem cell growth and cancer development.

(5 - azacytidine, Vidaza) A demethylating agent, this medicine interacts with DNA to restore normal growth of blood cells in the bone marrow.

(Dacogen) A demethylating agent, this drug interacts with DNA to restore normal growth of blood cells in the bone marrow.

Paligenosis, Mills explains, appears similar to apoptosis — the programmed death of cells as a normal part of an organism's growth and development — in that it seems to happen the same way in every cell, regardless of its location in the body.

Because DDX3 harbors a dominant nuclear localization in normal squamous cells and exerts a transactivation function on p21waf1 / cip1 promoter, presumably the inactivation of transcriptional modulation function of DDX3 through cytoplasmic mislocalization is relevant to the deregulation of cell growth in cancerous squamous cells.

The imaged embryos show abundant proliferation of cell growth (red, first column) in both normal and BRCA1 - deficient brains at this stage.

To explore the biological function of DDX3 on cell growth control, a colony formation assay was done in several tumor cell lines (HuH - 7, HCT116, and HeLa) and normal murine fibroblast cells (NIH 3T3) under the selection of G418.

Binding of JSRV sheep lung cells might interfere with the receptor's normal role in regulating cell proliferation, causing unregulated growth.

In addition to halting growth, senescent cells secrete abnormally large amounts of proteins that inflame the immune system and degrade the normal supporting tissue architecture.

CFU - GM assays using bone marrow derived cells yield very few colonies in repsonse to interleukin 3, but normal colony growth occurs in response to GM - CSF

Topics such as the mechanisms of cell injury in normal and dystrophic muscle, compensatory muscle regeneration and hypertrophy, and the effects of various therapies or voluntary exercise on muscle repair, satellite cell activation, muscle growth, bone density and age - related atrophy are examined using a large variety of cellular, molecular and whole - animal in vivo assays of function.

A protein known to play a role in transporting the molecular contents of normal cells into and out of various intracellular compartments can also turn such cells cancerous by stimulating a key growth - control pathway.

In addition, ActD has been shown to mimic nutlin - 3 in the activation of p53 - dependent transcription, induction of a reversible protective growth arrest in normal cells, and enhancement of the activity of the chemotherapeutic drugs, melphalan and etoposide, resulting in apoptosis of p53 positive human tumor cells [14In addition, ActD has been shown to mimic nutlin - 3 in the activation of p53 - dependent transcription, induction of a reversible protective growth arrest in normal cells, and enhancement of the activity of the chemotherapeutic drugs, melphalan and etoposide, resulting in apoptosis of p53 positive human tumor cells [14in the activation of p53 - dependent transcription, induction of a reversible protective growth arrest in normal cells, and enhancement of the activity of the chemotherapeutic drugs, melphalan and etoposide, resulting in apoptosis of p53 positive human tumor cells [14in normal cells, and enhancement of the activity of the chemotherapeutic drugs, melphalan and etoposide, resulting in apoptosis of p53 positive human tumor cells [14in apoptosis of p53 positive human tumor cells [14].

The researchers found that, when stimulated by insulin, diabetic fibroblasts produced less of the VEGF (vascular endothelial growth factor) signaling protein, a key player in boosting the growth of blood vessel cells, than normal fibroblasts did.

Because programmed cell death goes awry in leukemias and other cancers, Hu is currently examining lincRNA - EPS's function in normal and diseased human cells in an effort to determine whether it plays a role in tumor development and growth.

IL7R is expressed in HCC but not in normal liver cells, and can activate JAK2 to increase cell growth.57 SOCS3 is a negative regulator of the JAK / STAT signalling pathway, and can inhibit JAK2 itself.58 Therefore, inhibition of JAK2 by SOCS3 could result in decreased proliferation.

Researchers discovered in this study that the growth of cancer cells is selectively halted with zinc but leaves normal esophageal epithelial cells untouched.

Well, sure — cancer is, hands down, the scariest form of growth, and IGF - 1 in particular is famous not only for promoting the growth of normal cells; it is also infamous for promoting the growth of cancer cells.

1) Phytonutrients: * Occur naturally in fruits and vegetables * Promote the function of the immune system * Help fight off viruses as well as reduce inflammation * Associated with the treatment and / or prevention of cancer and cardiovascular disease 2) Enzymes: * Responsible for metabolic processes that occur within a cell and are necessary for sustaining life * Assist and play a large role in digestion, energy production, blood coagulation and contraction of muscles 3) Amino Acids: * The basic building blocks of protein * Absorption of amino acids is essential for your metabolism 4) Essential Fatty Acids: * Reduce the risk of heart disease and some forms of cancer * Improve mood * Decrease inflammation 5) Vitamins: * Essential for the normal growth and development of all human beings * Healthy maintenance of cell tissues and organs * Help process proteins, carbohydrates and fats required for utilization 6 & 7) Macro and Trace Minerals: * Involved in electrolyte balance of body fluids * Essential for normal cellular activity * Provide hardness to bones and teeth

Lauric Acid inhibited the viability of both cancer cell types without altering the growth of MCF - 10A normal breast epithelial cells, thus suggesting its specific potential to trigger antiproliferative effects in malignant cells.

Although a non - essential amino acid in normal cells, the demand for glutamine is dramatically increased throughout malignant transformation to support increased metabolic demands; namely, provision of catabolic substrates for ATP production and anabolic substrates for macromolecule biosynthesis.The intracellular glutamine pool is also critical for sustained activation of mTORC1 signalling, a master regulator of cell growth and protein translation, as well as prevention of apoptosis

This optimal blend of folates may work in conjunction with amino acids, chelated minerals, and other B vitamins to support normal cell growth and cardiovascular, neurologic and immune health.

We've identified that ketone bodies, i.e. fuels in the bloodstream that result from a very low carbohydrate diet, metabolically inhibit growth of 7 cancer cell lines in cell culture, but not 3 normal cell types.

In cell culture studies we published that ketone bodies (KB) inhibited growth of 7 different cancers from 20 - 50 %, leaving normal cells unaffected.

For example, in a petri dish, there are rice phytonutrients that can inhibit the growth of colon cancer cells, at greater and greater doses, while apparently leaving normal colon cells alone.