We have several ongoing projects designed to uncover the molecular mechanisms that regulate endocytosis, and to determine its involvement
in normal cellular processes and cancer.
Not exact matches
Carcinogens may cause cancer by altering
cellular metabolism or damaging DNA directly
in cells, which interferes with
normal biological
processes.
The technology offers unprecedented views of
cellular processes and will allow researchers to observe cells
in their natural state, an important step
in teasing out
normal and disease
processes.
Through
normal cellular processes, free radical - generating substances like peroxides are formed, but antioxidants
in the cell work to neutralize them and prevent oxidation.
Scientists at the Montreal Neurological Institute and Hospital - The Neuro, McGill University, have made important discoveries about a
cellular process that occurs during
normal brain development and may play an important role
in neurodegenerative diseases.
While
normal RNA regulation involves regulated and reversible assembly of RNA - protein particles, both increased
cellular age and mutation push the
process towards hyperassembly, which leads to altered pools of RNA or RNA regulatory proteins
in neurons that contribute to their eventual death.
For setting cancer
in the context of ageing tissue, study of
normal adult homeostasis is important — we are studying mutational
processes, clonal dynamics and
cellular competition
in thousands of non-cancerous cells and samples from a range of tissue types,
in health and disease.
seek to identify the mutational
processes underlying mutational signatures found
in cancers, characterise the mutational
processes operating
in normal cells, use phylogenetic analyses of somatic mutations
in humans to explore
cellular lineages during embryonic development
(9) Indeed, the degenerative aging
process is by definition one
in which the organism progressively accumulates damage to its
cellular and molecular components over time, so any genetic or environmental factor that leads to a greater burden of such damage will bear some resemblance to the aging phenotype, irrespective of the causal origin of the defect or its relationship to «
normal» aging.
This DNA becomes damaged
in the course of
normal cellular processes, and certain forms of mitochondrial DNA damage - to the thirteen genes needed for oxidative phosphorylation - produce malfunctioning mitochondria that can overtake their cells, either by replicating more readily or being more resistant to quality control mechanisms.
When heavy metals accumulate
in the body they can interrupt
normal cellular processes by binding with protein sites and replacing the metals that naturally occur
in the cell.
1) Phytonutrients: * Occur naturally
in fruits and vegetables * Promote the function of the immune system * Help fight off viruses as well as reduce inflammation * Associated with the treatment and / or prevention of cancer and cardiovascular disease 2) Enzymes: * Responsible for metabolic
processes that occur within a cell and are necessary for sustaining life * Assist and play a large role
in digestion, energy production, blood coagulation and contraction of muscles 3) Amino Acids: * The basic building blocks of protein * Absorption of amino acids is essential for your metabolism 4) Essential Fatty Acids: * Reduce the risk of heart disease and some forms of cancer * Improve mood * Decrease inflammation 5) Vitamins: * Essential for the
normal growth and development of all human beings * Healthy maintenance of cell tissues and organs * Help
process proteins, carbohydrates and fats required for utilization 6 & 7) Macro and Trace Minerals: * Involved
in electrolyte balance of body fluids * Essential for
normal cellular activity * Provide hardness to bones and teeth
When heavy metals reach the blood
in their free forms, they disturb
normal cellular and metabolic
processes as well as disrupt hormonal balance and also immune function.
Not only that, saturated fatty acids are important for
cellular membranes,
normal hormone production, organ padding, calcium absorption and immune function, as well as signaling and stabilization
processes in our bodies.