Sentences with phrase «in normal mice as»

The researchers also showed that DENV NS1 caused similar levels of blood vessel leak in normal mice as in mice bred to have inhibited cytokine activity, suggesting that cytokines were not necessary for this effect.

The researchers then decided to see what would happen if they boosted sirtuin levels in normal mice as they aged.

Not exact matches

In contrast, control mice expressing the normal human prion sequence resisted infection when exposed to same materials — just as humans seem to, even those who consume venison meat.

The behavioral tests used here modeled one dimension of the disease — an inability to experience pleasure from normal activities — but not others, such as stress and anxiety, and probably tap into different brain mechanisms in mice than in humans, he says.

For this study the researchers targeted very specific types of GABA receptors to improve social behaviors with clonazepam, but the team also found that by using a different drug, they could target other GABA receptors and actually reduce the ability to socially interact in normal mice — underscoring that future medications would need to target very specific receptors so as not to diminish the drug's impacts.

Skin grafts of such transgenic mice were rejected by normal C57BL / 10 mice, suggesting that the foreign SLA antigen expressed in the transgenic mice is recognized as a functional transplantation antigen.

In healthy mice, normal sperm line up at the center of a part of the testes known as the seminiferous tubule, ready for release (left, arrows).

But unlike the normal mice, those with altered macrophages showed no signs of inflammation, such as changes in insulin production, high levels of immune chemicals, and macrophages in their belly fat.

When they next measured responses in the auditory regions of the brain, a more sensitive test, the mice responded to much quieter sounds: 19 of 25 mice heard sounds quieter than 80 decibels, and a few could heard sounds as soft as 25 - 30 decibels, like normal mice.

«When we switched off the support cells, the mice licked the air in anticipation of the milk only half as often as normal,» Masmanidis said.

By examining the brains of these mice, the researchers observed a substantial decrease in inhibitory CA2 neurons, as compared to a control group of normal, healthy mice — a change remarkably similar to that previously observed in postmortem examinations of people with schizophrenia.

In those normal mice, A-beta levels weren't as high as they were in the mutated mice, but the fact that they existed was notable, says study coauthor Weihong Song of the University of British Columbia in VancouveIn those normal mice, A-beta levels weren't as high as they were in the mutated mice, but the fact that they existed was notable, says study coauthor Weihong Song of the University of British Columbia in Vancouvein the mutated mice, but the fact that they existed was notable, says study coauthor Weihong Song of the University of British Columbia in Vancouvein Vancouver.

He and colleagues at the University of California, San Francisco, injected the brains of mice with prions they had created in the lab by misfolding normal prion protein, known as PrP.

In a study published October 30 in Neuron, the scientists show that mice genetically altered so they don't produce serotonin didn't scratch as much as normal mice when exposed to irritantIn a study published October 30 in Neuron, the scientists show that mice genetically altered so they don't produce serotonin didn't scratch as much as normal mice when exposed to irritantin Neuron, the scientists show that mice genetically altered so they don't produce serotonin didn't scratch as much as normal mice when exposed to irritants.

Even though the mice appeared normal in many ways, they were unable to tune down their responses to external signals such as noises.

After LPS was added, the neutrophils in a mouse lung deficient in CD11b crawled about a third of the distance as the neutrophils in a normal mouse lung.

Normal mice watching chronically itchy mice in other cages increased their own scratching in as little as 5 seconds, whereas mice placed near nonitchy mice didn't show any increase in scratching, researchers report in Science.

Klebsiella pneumoniae is usually a normal resident in the mouth of healthy individuals, but as demonstrated in an experiment on specific pathogen - free mice treated and untreated with the antibiotic ampicillin, they can colonize in the gut and activate TH1 cells when antibiotics disturb the gut microbial balance and weaken tolerance for the colonization of oral bacteria reaching the intestine.

Knocking out a particular gene in muscle lets mice run twice as far as normal; knocking out the same gene in fat cells allows the animals to put on weight without developing type - 2 diabetes.

As a final test to see whether parasites could directly access the brain from the blood, the researchers infected mice with a mixture of normal parasites and mutants that was unable to reproduce, each labeled in different colors.

As a result, they have less than half of the fat tissue found in normal, aged mice.

These normal in vivo immune responses in IL -2-deficient mice question the importance of IL - 2 as defined by in vitro studies.

Untreated 3xTg mice displayed impaired learning and memory as expected, but 3xTg mice that were administered PD146176 for 3 months were indistinguishable from normal mice in a memory test.

They found that levels of an enzyme involved in ketone metabolism, known as BDH1, were twice as high in mice with both early stage and complete heart failure compared to normal animals.

A study published January 4th in Cell Stem Cell demonstrates that a gene therapy approach can lead to the long - term survival of functional beta cells as well as normal blood glucose levels for an extended period of time in mice with diabetes.

When they restored normal nitric oxide levels by having mice breathe in the short - lived gas — as patients have done in clinical trials — cell adhesion did not increase when oxygen levels decreased.

In a paper appearing online this week in the early edition of the journal Proceedings of the National Academy of Sciences, University of California, Berkeley, scientists who invented the photoswitch therapy and veterinary colleagues at the School of Veterinary Medicine of the University of Pennsylvania (UPenn) report that blind mice regained the ability to navigate a water maze as well as normal micIn a paper appearing online this week in the early edition of the journal Proceedings of the National Academy of Sciences, University of California, Berkeley, scientists who invented the photoswitch therapy and veterinary colleagues at the School of Veterinary Medicine of the University of Pennsylvania (UPenn) report that blind mice regained the ability to navigate a water maze as well as normal micin the early edition of the journal Proceedings of the National Academy of Sciences, University of California, Berkeley, scientists who invented the photoswitch therapy and veterinary colleagues at the School of Veterinary Medicine of the University of Pennsylvania (UPenn) report that blind mice regained the ability to navigate a water maze as well as normal mice.

They found that the mice can develop damage to the optic nerve despite normal pressure in the eye following KPro surgery and identified TNFa and IL - 1 as inflammatory factors involved in this process, with high levels of TNFa mediating the damage to the optic nerve.

Mathias Chamaillard at the University of Lille, France, and his colleagues discovered that the skin cancer drug ipilimumab isn't as effective at treating cancer in mice born without bacteria in their gut, compared with mice with normal bacteria.

As the mice developed, Verma's team found that the rodents» brains were only a third of their normal size, with particularly striking reductions in brain areas involved in learning and memory.

The researchers then placed the mutant mice, as well as normal mice, in a chamber with a metal floor connected to an electrical source.

But many in the field will be waiting for the next steps: testing whether the resulting mouse pups are genetically normal, trying out the technique in other animals, and using other and less controversial types of cells — such as stem cells that can be extracted and cryopreserved from adult testicular tissue — as the starting point.

Last year, as a first step in defining a «normal» lab mouse microbiome, they analyzed feces from mice from two major vendors.

The next day, the mutant and normal mice were placed in the same shock chamber and then were put in a cage that was similar but had subtle differences such as its odor and the shape of its roof and type of floor.

The normal mice and the AS model mice with diminished expression of the Na / K - ATPase subunit searched the correct area of the maze in the same amount of time.

«The J20 / caspase -2 null mice showed the same dendritic spine density and morphology as the normal mice — as opposed to the deficits in the J20 mice,» said co-lead author Julio Pozueta, PhD.

They examined behaviors of the following types of mice: normal mice, AS model mice, mice that had reduced levels of the Na / K - ATPase, and AS model mice in which expression of the subunit of Na / K - ATPase was reduced.

In visually impaired mice, the transplant allowed for the restoration of normal vision, as demonstrated by tests of visual nerve signals and a swimming maze test.

To see what was happening in the brains of these ankyrin - G mutant mice, the researchers analyzed the cell components in inhibitory synapses connecting with pyramidal neurons, finding that two proteins known as GAT1 and GAD67 — responsible for making the neurochemical GABA that dials back nerve impulses — were at much lower levels in the synapses on pyramidal neurons in ankyrin - G mutant mice than in normal mice.

Those mice showed the expected signs of anxiety, such as moving around less open spaces and taking longer to start eating in new environments as compared with normal animals.

To figure out what goes wrong in these mice, a team led by Jeremy Nathans, a molecular biologist at Johns Hopkins University School of Medicine in Baltimore, Maryland, examined the skin of newborn Frizzled6 and normal mice under a microscope each day as their first hairs grew in.

As seen through a microscope, the leg bone of a normal mouse (left) makes considerably less new bone than a mouse that produces high levels of a signaling protein, WNT7B, that stimulates new bone growth (shown in pink on the right).

The drug wasn't as effective at treating cancer in these mice compared with mice with normal gut bacteria.

When the scientists took normal mice and temporarily reduced cholesterol creation in the hypothalamus with a technique known as RNA interference, the animals started eating more and gained significant weight.

The mouse lifespan study is the important news here, as it demonstrates meaningful extension of median life span through removal of senescent cells, the first such study carried out in normal mice for this SENS - style rejuvenation technology.

Another behavior that scientists have observed in Huntington's disease model mice is that they aren't as motivated as normal mice to drink sweet water.

J147 increases the levels of BDNF in the hippocampus of normal rats, as well as in huAPP / PS1 transgenic mice [7], and its synthetic precursor, CNB - 001, increases BDNF levels in rat traumatic brain injury models [54].

This early hint that age - related changes in EP2 action in microglia might be promoting some of the neuropathological features implicated in Alzheimer's was borne out in subsequent experiments for which Andreasson's team used mice genetically predisposed to get the mouse equivalent of Alzheimer's, as well as otherwise normal mice into whose brains the scientists injected either A-beta or a control solution.

It should be noted, however, that while a study on senescent cell ablation in genetically normal mice would provide at least some evidence on the effect of senescent cells (and their ablation) on promoting cancer, even such a study would likely show less effect than could be anticipated in a large mammal model, since even normally - aging mice rarely suffer metastatic disease to the extent of aging humans, as sheer primary tumor volume is generally sufficient to be fatal to mice.

PHENOMIN - CIPHE, on the strength of its expertise in genetics and mouse immunology, is positioned as a pioneer in multiparametric analysis of the immune system of mutant mice in normal conditions or exposed to risks of infection, by an integration of innovative research and technical knowledge in the field of flow and mass cytometry as well as advanced microscopy.