Sentences with phrase «in normal mice for»

The mouse lifespan study is the important news here, as it demonstrates meaningful extension of median life span through removal of senescent cells, the first such study carried out in normal mice for this SENS - style rejuvenation technology.

Not exact matches

Read this post for a refresher, but the short of it is they wreck your gut with inflammation that is on the order of causing (in mice anyway) IBD if predisposed, and if with a normal immune system, say hello to chronic low - grade intestinal inflammation and metabolic syndrome.

For this study the researchers targeted very specific types of GABA receptors to improve social behaviors with clonazepam, but the team also found that by using a different drug, they could target other GABA receptors and actually reduce the ability to socially interact in normal mice — underscoring that future medications would need to target very specific receptors so as not to diminish the drug's impacts.

The mice were allowed at least 2 weeks for recovery from the implant procedure in order to return to normal function.

In healthy mice, normal sperm line up at the center of a part of the testes known as the seminiferous tubule, ready for release (left, arrows).

They compared mice genetically engineered to have increased levels of SIRT6 with normal mice, engineering the mice in two different ways to control for genetic influences.

After three weeks in cold temperatures, the mice were returned to normal temperatures and analyzed for glucose (blood sugar) metabolism.

But the customary setup in such experiments — fiber - optic cables implanted in the brain and a heavy helmet linked to a laser — is invasive and cumbersome for mice, the usual subjects, severely hampering researchers» ability to observe normal activity and social behavior.

For instance, they took just half the time of normal mice to venture into new avenues and well - lit spaces, yet gave up far sooner in a swimming endurance test.

A string of such beautiful, interventionist mice experiments over the past several years has revealed specific circuit elements involved in a variety of normal and pathological behaviors: depression, behavioral conditioning, Parkinson's disease and cortical oscillations critical for attention, among others.

Lastly, they plan to vary the timing of exposure to the various diets in the mouse model of autism, by, for example, giving pregnant mice a high - glycemic index diet and then keeping their pups on a normal diet.

«Just one transplant of the human EPO - producing cells treated kidney anaemia in mice, keeping their haemoglobin levels in the normal range for the remaining 7 - month lifespan of the animals,» says Kenji Osafune, of Kyoto University in Japan, who led the team.

In a separate study, Steven Kliewer, a molecular biologist at the University of Texas Southwestern Medical Center in Dallas, and colleagues fed normal mice and transgenic mice that overproduce the hormone a regular diet, then starved them for a daIn a separate study, Steven Kliewer, a molecular biologist at the University of Texas Southwestern Medical Center in Dallas, and colleagues fed normal mice and transgenic mice that overproduce the hormone a regular diet, then starved them for a dain Dallas, and colleagues fed normal mice and transgenic mice that overproduce the hormone a regular diet, then starved them for a day.

In that time, the normal mice produced regularly, giving birth to a litter of seven or eight pups approximately every 21 days, for a total of about 60 baby mice.

Researchers at University of California San Diego School of Medicine and in the Division of Biological Sciences at UC San Diego have identified a protein in mice that must be present in eggs for them to complete normal development.

In an independent effort, they introduced progressively smaller pieces of DNA from the large region known to contain the gene into embryos of the mutant mice, looking for the smallest piece that would correct the mutation in adult mice and restore a normal rhythIn an independent effort, they introduced progressively smaller pieces of DNA from the large region known to contain the gene into embryos of the mutant mice, looking for the smallest piece that would correct the mutation in adult mice and restore a normal rhythin adult mice and restore a normal rhythm.

Klebsiella pneumoniae is usually a normal resident in the mouth of healthy individuals, but as demonstrated in an experiment on specific pathogen - free mice treated and untreated with the antibiotic ampicillin, they can colonize in the gut and activate TH1 cells when antibiotics disturb the gut microbial balance and weaken tolerance for the colonization of oral bacteria reaching the intestine.

When fed a diet containing cholesterol, saturated fat, and bile acids for 3 weeks, the transgenic mice, in contrast to normal mice, did not develop a detectable increase in plasma LDL.

In the next experiment, Karsenty looked for evidence of such signaling effects in osteoblasts from normal micIn the next experiment, Karsenty looked for evidence of such signaling effects in osteoblasts from normal micin osteoblasts from normal mice.

Untreated 3xTg mice displayed impaired learning and memory as expected, but 3xTg mice that were administered PD146176 for 3 months were indistinguishable from normal mice in a memory test.

A study published January 4th in Cell Stem Cell demonstrates that a gene therapy approach can lead to the long - term survival of functional beta cells as well as normal blood glucose levels for an extended period of time in mice with diabetes.

Next, Prins exposed the mice to elevated estrogen levels for two to four months, to mimic the normal rise in estrogen seen in aging men.

To investigate, Akhtar deleted the gene for Rac1 in female mice; their first litter of pups survived, but they were smaller than normal — probably because the milk they received contained less fat and protein than normal.

For the first time, researchers have been able to grow, in a lab, both normal and primary cancerous prostate cells from a patient, and then implant a million of the cancer cells into a mouse to track how the tumor progresses.

The quest for better opioids got a much - needed jolt in 1999, when researchers at Duke University showed that mice lacking a protein called beta - arrestin 2 got more pain relief from morphine than normal mice did.

For comparison, bacteria grown in a laboratory on Earth in normal gravity infected another group of mice.

But many in the field will be waiting for the next steps: testing whether the resulting mouse pups are genetically normal, trying out the technique in other animals, and using other and less controversial types of cells — such as stem cells that can be extracted and cryopreserved from adult testicular tissue — as the starting point.

We were able to prove for the first time that REM sleep is indeed critical for normal spatial memory formation in mice,» explains Williams, whose team is also part of the CIUSSS de l'Ouest - de - l'Île - de-Montréal research network.

For instance, they took just half the time of normal mice to venture into new avenues and lighted spaces, yet gave up far sooner in a swimming endurance test.

Monitoring groups of mice, one group receiving normal levels of protein in the diet and the other group nourished with low levels of protein for five weeks, researchers were able to uncover the damaging effect a reduction of protein can cause to the structure of this vital organ.

In the study, normal mice with a muscle injury received steroids just before injury and for two weeks after the injury.

The researchers looked for genes that were turned on by dHAND in normal mice, but nonfunctioning when dHAND was shut down.

In mice carrying the schizophrenia - associated mutation, early development was normal, suggesting that truncated Shank3 can adequately fill in for the normal version during this stagIn mice carrying the schizophrenia - associated mutation, early development was normal, suggesting that truncated Shank3 can adequately fill in for the normal version during this stagin for the normal version during this stage.

In baseline tests, the high - energy ankyrin - G mice usually swam longer, only floating for about 10 seconds of the 200 second test compared to the normal mice that floated about 50 seconds, but after several sessions with the bully mice, the ankyrin - G mice were quick to give up and float, remaining still for well over 100 seconds on average.

Although muscle cells did not reduce in size or number in mice lacking a protective antioxidant protein, they were weaker than normal muscle cells, researchers from the Barshop Institute for Longevity and Aging Studies at The University of Texas Health Science Center San Antonio found.

In visually impaired mice, the transplant allowed for the restoration of normal vision, as demonstrated by tests of visual nerve signals and a swimming maze test.

To see what was happening in the brains of these ankyrin - G mutant mice, the researchers analyzed the cell components in inhibitory synapses connecting with pyramidal neurons, finding that two proteins known as GAT1 and GAD67 — responsible for making the neurochemical GABA that dials back nerve impulses — were at much lower levels in the synapses on pyramidal neurons in ankyrin - G mutant mice than in normal mice.

The reason for Frizzled6 mice's messy hair soon became obvious: The mutant mice are born with hair follicles that point in random directions, while normal mice have follicles pointing more or less in the direction needed for the hair to lay flat.

But Hecht notes that although CNP breaks down within minutes in the body, decoy FGFR3 lasts for hours and produces normal growth in the mice with just twice - weekly injections.

The researchers put the mice in a warm chamber for 6 hours, which raised their core temperature 2.7 C degrees above normal, to 39.5 C (about 103 F).

The researchers also showed that DENV NS1 caused similar levels of blood vessel leak in normal mice as in mice bred to have inhibited cytokine activity, suggesting that cytokines were not necessary for this effect.

Interestingly NPGL levels, which plummeted in the 5 - week - long high - fat - diet mice — fell back to normal levels in mice who gorged themselves for the longer period of 13 weeks.

In two separate novel - object recognition tests, the CA2 - deficient mice showed a normal preference for an object they had not previously encountered, showing that the mice did not have a global lack of interest in noveltIn two separate novel - object recognition tests, the CA2 - deficient mice showed a normal preference for an object they had not previously encountered, showing that the mice did not have a global lack of interest in noveltin novelty.

«The successful retrieval of memories in AD mice by increasing the number of spines for normal memory processing only in the memory cells, rather than in a broad population of cells, highlights the importance of highly - targeted manipulation of neurons and their circuits for future therapies.

Gene expression patterns in normal adult or the developing retina have been reported for mouse [18 — 23], aged and normal adult human [24 — 26], canine [27], and rabbit [28].

Importantly, 25 of the 115 transcripts, shared by EFTF - expressing pluripotent cells and the EF, encode for 15 genes that are both expressed in retinal stem / progenitor cells and required for normal eye formation in frogs, fish, mice, or humans (Figure 1C; Table S1).

«The successful retrieval of memories in AD mice by increasing the number of spines for normal memory processing only in the memory cells, rather than in a broad population of cells, highlights the importance of highly - targeted manipulation of neurons and their circuits for future therapies,» said Tonegawa in a statement.

LA JOLLA, CA — Reviving a theory first proposed in the late 1800s that the development of organs in the normal embryo and the development of cancers are related, scientists at the Salk Institute for Biological Studies have studied organ development in mice to unravel how breast cancers, and perhaps other cancers, develop in people.

Mice lacking normal cilia in parts of their brain that were important for memory had trouble remembering a painful shock.

This early hint that age - related changes in EP2 action in microglia might be promoting some of the neuropathological features implicated in Alzheimer's was borne out in subsequent experiments for which Andreasson's team used mice genetically predisposed to get the mouse equivalent of Alzheimer's, as well as otherwise normal mice into whose brains the scientists injected either A-beta or a control solution.