Sentences with phrase «in normal mouse brains»

The researchers measured 40 % more of the enzyme PDE4A5 in the brains of sleep - deprived mice than in normal mouse brains.

Not exact matches

These mice performed better than their normal counterparts on learning tests well into old age, and their brains did not exhibit the decline in neurogenesis typically seen in aged mice.

The behavioral tests used here modeled one dimension of the disease — an inability to experience pleasure from normal activities — but not others, such as stress and anxiety, and probably tap into different brain mechanisms in mice than in humans, he says.

When they next measured responses in the auditory regions of the brain, a more sensitive test, the mice responded to much quieter sounds: 19 of 25 mice heard sounds quieter than 80 decibels, and a few could heard sounds as soft as 25 - 30 decibels, like normal mice.

The researchers discovered that in brain regions involved in regulating anxiety — the amygdala and prefrontal cortex — microbe - free mice had an overabundance of some types of microRNA and a shortage of others compared with normal mice.

Alzheimer's mice with normal BACE1 levels experienced a steady increase in plaques, clearly seen in samples of their brains.

But the customary setup in such experiments — fiber - optic cables implanted in the brain and a heavy helmet linked to a laser — is invasive and cumbersome for mice, the usual subjects, severely hampering researchers» ability to observe normal activity and social behavior.

By examining the brains of these mice, the researchers observed a substantial decrease in inhibitory CA2 neurons, as compared to a control group of normal, healthy mice — a change remarkably similar to that previously observed in postmortem examinations of people with schizophrenia.

But these plaques were also inside the brains of the normal mice in the joined pairs.

He and colleagues at the University of California, San Francisco, injected the brains of mice with prions they had created in the lab by misfolding normal prion protein, known as PrP.

«It was particularly exciting to see plasticity in the neurons impaired by mHTT,» said Davidson, noting that in the HD mice, brain areas that had begun to atrophy recovered volume and permitted better motor function after the researchers restored mTORC1 activity to more normal levels.

Post mortems showed that brain connections lost in the untreated mice remained healthy, and completely normal protein production had resumed in the treated animals, even though the prions continued to accumulate.

As a final test to see whether parasites could directly access the brain from the blood, the researchers infected mice with a mixture of normal parasites and mutants that was unable to reproduce, each labeled in different colors.

When the mice died at 31 weeks, their brains had 20 % fewer neurons than normal mouse brains in regions that Huntington's strikes in people.

Normal mice with p16 had fewer neural stem cells in one part of the brain and fewer new neurons in the olfactory bulb, again demonstrating p16's ability to inhibit regeneration.

The investigators reached this conclusion by comparing the integrity and development of the blood - brain barrier between two groups of mice: the first group was raised in an environment where they were exposed to normal bacteria, and the second (called germ - free mice) was kept in a sterile environment without any bacteria.

With thoughts of a jolt fresh in their brain, mice with normal levels of α - CaMKII froze up when they returned to the chamber an hour later, while mice with boosted levels remained calm.

As the mice developed, Verma's team found that the rodents» brains were only a third of their normal size, with particularly striking reductions in brain areas involved in learning and memory.

The drug restored in the mice normal levels of serotonin, a neurotransmitter communicating messages between nerve cells in the brain.

In mice with A-T, the cerebellum appears normal and they do not exhibit the obvious degeneration seen in the human braiIn mice with A-T, the cerebellum appears normal and they do not exhibit the obvious degeneration seen in the human braiin the human brain.

The brains of the mice were smaller than normal and had fewer neurons in areas that controlled the affected behaviors.

To see what was happening in the brains of these ankyrin - G mutant mice, the researchers analyzed the cell components in inhibitory synapses connecting with pyramidal neurons, finding that two proteins known as GAT1 and GAD67 — responsible for making the neurochemical GABA that dials back nerve impulses — were at much lower levels in the synapses on pyramidal neurons in ankyrin - G mutant mice than in normal mice.

Indeed, those mice in Schwarzchild's study that were pretreated with caffeine retained near - normal dopamine levels when exposed to a chemical known to induce Parkinson's - like symptoms by decreasing brain dopamine.

In normal mice, ginkgo halved the volume of brain tissue injured after a stroke, but it had little effect on mutant mice that lacked heme oxygenase.

They observed a significant decrease in the number of proliferating stem cells in the brains of HIV / gp120 - mice compared with similar tissue from normal, wild - type mice.

Finally, we generate new tools and mouse models to study the role of de novo protein synthesis in normal brain function and in pathophysiology associated with neurodevelopmental and neurodegenerative disease.

J147 increases the levels of BDNF in the hippocampus of normal rats, as well as in huAPP / PS1 transgenic mice [7], and its synthetic precursor, CNB - 001, increases BDNF levels in rat traumatic brain injury models [54].

When these mice were housed in chambers that contained normal air containing 21 percent oxygen, the equivalent of what a person would breathe at sea level, they developed brain lesions and had a median survival length of 58 days.

Mice lacking normal cilia in parts of their brain that were important for memory had trouble remembering a painful shock.

This early hint that age - related changes in EP2 action in microglia might be promoting some of the neuropathological features implicated in Alzheimer's was borne out in subsequent experiments for which Andreasson's team used mice genetically predisposed to get the mouse equivalent of Alzheimer's, as well as otherwise normal mice into whose brains the scientists injected either A-beta or a control solution.

In addition to the normal tools of the cell biologist's trade, Simona's lab uses intravital imaging to peer into the brains of mice.

The researchers looked at the dentate gyrus, a specific area of the brain that is critical to memory and particularly vulnerable in Alzheimer's disease, and compared the genes that were turned on and off in normal mice and a mouse model of Alzheimer's disease.

In their experiments the researchers measured acidity in the endosomes of brain cells of normal mice and in mice with mutations in the NHE6 genIn their experiments the researchers measured acidity in the endosomes of brain cells of normal mice and in mice with mutations in the NHE6 genin the endosomes of brain cells of normal mice and in mice with mutations in the NHE6 genin mice with mutations in the NHE6 genin the NHE6 gene.

Because the SD of brain progranulin in wild - type mice was about 10 % of the mean level, progranulin levels in Grn + / − mice would need to increase from 50 % of normal to 80 % of normal, i.e. by 30 % of the normal value, to reach the lower limit of normal.

The brain cells of normal mice seemed unaffected, suggesting the protein had stayed in the blood.

But when they looked at the activity in the bad NMDA channels, they found more in HD mouse brains than normal mouse brains.

Glucose is the sole metabolic fuel used for nearly all brain functions under normal physiological conditions, but the brain will metabolize ketone bodies for energy when access to glucose is limited, as would occur during water - only therapeutic fasting in humans or during calorie restriction in mice.

Following disruption of the normal flora balance, mice became less cautious, and changes in the animals» brain - derived neurotrophic factor — a protein associated with mood disorders — increased significantly.

The researchers also showed that regular feeding with the Lactobacillus strain caused changes in the expression of receptors for the neurotransmitter GABA in the mouse brain, which is the first time that it has been demonstrated that potential probiotics have a direct effect on brain chemistry in normal situations.