Sentences with phrase «in nude mice»
We previously showed that follistatin can also block myostatin activity in vivo; specifically, we showed that follistatin can ameliorate the cachexia induced by high level expression of myostatin in nude mice [21] and that transgenic mice expressing follistatin in muscle have dramatic increases in muscle mass [19].
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Moreover, one compound substantially decreased the growth of human melanoma xenografts in nude mice without any apparent side effects.
The Rac inhibitor EHop - 016 Inhibits Mammary Tumor Growth And Metastasis In A Nude Mouse Model Translational Oncology PMID: 25389450 [PubMed] PMCID: PMC4225654.
The Rac inhibitor EHop - 016 inhibits mammary tumor growth and metastasis in a nude mouse model.
Hedgehog inhibitor sonidegib potentiates (177) Lu - octreotate therapy of GOT1 human small intestine neuroendocrine tumors in nude mice.
Antagonistic analogs of growth hormone - releasing hormone increase the efficacy of treatment of triple negative breast cancer in nude mice with doxorubicin; A preclinical study
Inhibition of SDF - 1 / CXCR4 interaction using an anti-CXCR4 monoclonal antibody significantly impairs the migration of breast cancer cells to regional lymph nodes and lung in nude mice [28].
On the basis of studies on the XMRV - producing human prostate cancer cell lines CWR22Rν1 and CWR - R1 and their progenitor tumour xenograft CRW22, they concluded that XMRV infections were caused by contamination during in vivo passaging in nude mice.
Finally, a 2011 study from Paprotka, et al. provided strong evidence that XMRV is a 22Rv1 - derived laboratory contaminant originating from recombination of two mouse endogenous retroviruses during serial passage of CWR22 in nude mice [38].
In these experiments, Berger and colleagues show that somatic PREX2 mutations identified through whole - genome sequencing of human melanoma can contribute to enhanced lethality of tumor xenografts in nude mice (Figure 3B, S6B, and S6C; Berger et al., 2012).
Curcumin suppresses the paclitaxel - induced nuclear factor - kappaB pathway in breast cancer cells and inhibits lung metastasis of human breast cancer in nude mice.