Discovery of a ligand that compensates for decreased endogenous agonist potency of melanocortin - 4 receptor polymorphisms identified
in obese humans.
Further, the administration of dopamine agonists such as bromocriptine and methylphenidate have been shown to significantly reduce body fat and body weight
in obese humans [47, 48].
Calorie Restriction - like Effects of 30 Days of Resveratrol Supplementation on Energy Metabolism and Metabolic Profile
in Obese Humans Cell Metabolism 2011 (Nov 2); 14 (5): 612 — 622 ~ FULL TEXT The result of just 30 days on resveratrol were impressive: (1) The same gene regulators (AMPK, SIRT1 and PGC - 1a) were activated in this study as are activated by caloric restriction and resveratrol in mice and endurance training in humans.
Alternate day fasting increases LDL particle size independently of dietary fat content
in obese humans
In obese humans, substitution of carbohydrate with protein leads to far greater weight loss, nearly twice as much.
We estimate that the percentage of macrophages in adipose tissue ranges from under 10 % in lean mice and humans to over 50 % in extremely obese, leptin - deficient mice and nearly 40 %
in obese humans.
In previous studies, Chong Wee Liew, assistant professor of physiology and biophysics in the UIC College of Medicine, and his colleagues found that
in obese humans TRIP - Br2 was turned - up in visceral fat but not in subcutaneous fat.
Researchers theorized that something similar might be going on
in obese humans, but when they began taking blood samples, they found that obese people show very high levels of leptin.
Sucralose, when studied
in obese human volunteers, raises the insulin level 22 % higher than water.
Green coffee bean extract (GCBE) also contains chlorogenic acids, and a recent study found that GCBE supplementation reduced body fat and resting heart rate
in obese human subjects, though researchers weren't sure whether the caffeine content of GCBE was partly responsible.»
Not exact matches
When the researchers gave concentrated broccoli sprout extracts to 97
human type 2 diabetes patients
in a 12 - week randomized placebo - controlled trial,
obese participants who entered the study with dysregulated disease demonstrated significantly decreased fasting blood glucose levels compared to controls.
The large amounts of fat around the testes of
obese mice, «could alter the environment and encourage epigenetic changes», says Teague, who presented the results at the 14th World Congress on
Human Reproduction
in Melbourne, Australia, this month.
The level of POPs needed to have an adverse affect
in humans is unknown, so it should not stop
obese people trying to lose weight, says Amanda Sainsbury - Salis at the Garvan Institute of Medical Research
in Sydney, Australia.
The scientists are now expanding their research to larger numbers of animals and they are also planning a study to look at addiction - like behaviours
in obese people to see how well their results translate to
humans.
The mechanism making
obese people have high blood pressure has been pinpointed
in mice, so we might be able to make drugs to block it
in humans
A common antioxidant found
in human breast milk and foods like kiwi fruit can protect against nonalcoholic fatty liver disease (NAFLD)
in the offspring of
obese mice, according to researchers at the University of Colorado Anschutz Medical Campus.
«Our knowledge gained from penguins provides novel insight into the gait mechanics of
humans with increased lateral movements, such as
in pregnant women or
obese individuals,» he says.
«Perhaps supplementing the diet of
obese pregnant mothers with PQQ, which has proven safe
in several
human studies, will be a therapeutic target worthy of more study
in the battle to reduce the risk of NAFLD
in babies,» Jonscher said.
In humans, as in mice, fat cells of the obese already produced plenty of leptin — more in fact than those of their thin counterparts, since the level of leptin was directly proportional to the amount of fa
In humans, as
in mice, fat cells of the obese already produced plenty of leptin — more in fact than those of their thin counterparts, since the level of leptin was directly proportional to the amount of fa
in mice, fat cells of the
obese already produced plenty of leptin — more
in fact than those of their thin counterparts, since the level of leptin was directly proportional to the amount of fa
in fact than those of their thin counterparts, since the level of leptin was directly proportional to the amount of fat.
In the human abdominal adipose (fat) tissue of lean individuals, the amounts of Pellino3 are high, but in adipose tissue from obese individuals the levels of Pellino3 fal
In the
human abdominal adipose (fat) tissue of lean individuals, the amounts of Pellino3 are high, but
in adipose tissue from obese individuals the levels of Pellino3 fal
in adipose tissue from
obese individuals the levels of Pellino3 fall.
In one recent test, mice implanted with fecal microbes from thin
humans stayed thin, while mice given bacteria from
obese people gained weight.
In both human and laboratory studies, the offspring of mothers who are obese or consume a high - fat diet during pregnancy are much more likely to be overweight and have weight - related problems such as metabolic syndrome, diabetes and heart disease later in lif
In both
human and laboratory studies, the offspring of mothers who are
obese or consume a high - fat diet during pregnancy are much more likely to be overweight and have weight - related problems such as metabolic syndrome, diabetes and heart disease later
in lif
in life.
«If
human offspring from
obese mothers have a similar risk for developing fibrosis as we see
in mice, we may be able to predict who is going to develop more serious disease,» said Thompson.
To explore the relevance of these results to
humans, the TSRI team worked with collaborating researchers
in Australia to test fat samples from
obese humans and diabetics.
Artifacts from that period — the
obese human and animal figurines and the phallic symbols carved
in stone or bone and modeled
in clay — point to the idea that the people had an obsession with the living world and its successful propagation through the descent group or lineage.
To determine how the drug works
in the
human brain, Mantzoros and colleagues observed 48
obese men and women — half taking the drug, half taking a placebo — over the course of a four - week experiment.
Given that adipose tissue (which makes up between 15 and 20 % of the body weight
in healthy people) is a source of inflammation
in obese individuals, Christine Bourgeois and Olivier Lambotte, from the University Paris SUD, France, and colleagues, decided to investigate a possible role of the adipose tissue
in humans infected with HIV and
in macaques infected with simian immunodeficiency virus (SIV, an HIV relative that causes AIDS - like disease
in some non-human primates).
Human brains naturally shrink with age, but previous research has shown that this seems to happen more quickly
in obese people.
Cytos, a biotechnology company outside of Zurich, Switzerland, is testing a different antighrelin vaccine
in a clinical trial of 112
obese humans; results, says Martin Bachmann, Cytos's chief scientific officer, will be available
in November.
Skeletal muscle tissue also produces increased amounts of iNOS and TNF - α
in obese compared with lean rodents and
humans (21, 71).
This is similar to the difference between
obese and slender
humans, and many researchers believe that burning more carbohydrates relative to fats can lead to fats gradually accumulating
in the body.»
Since most
humans with NASH are
obese and insulin resistant, this represents an important difference
in how MCD diets model
human NASH.
Also
in humans who are
obese and diabetic, appear to have high expression of PTP1B.
Her team first looked at 15
obese and 20 lean Labrador retrievers two years ago, examining three genes known to affect obesity and weight
in humans.
Symposia VI: Cardiovascular Benefits of Exercise: Insights from
Human Studies The session will cover improving exercise tolerance
in heart failure, reversal of impaired cardiac function
in obese adolescents, the effect of exercise on left ventricular compliance and diastolic function
in the elderly and attenuating premature cardiovascular aging
in Type 2 diabetes through exercise.
«From other research, a Mediterranean - style diet, richer
in MUFA (from olive or rapeseed oils) and other unsaturated oils at the expense of saturated fats, appears protective of heart disease and cancer
in humans — even
in overweight (but not
obese) subjects.
Using targeted and whole - exome sequencing, we studied 32
human and 87 rodent obesity genes
in 2,548 severely
obese children and 1,117 controls.
CD36 - and GPR120 - mediated Ca2 + signaling
in human taste bud cells mediates differential responses to fatty acids and is altered
in obese mice.
In one recent study,
obese rats that ate the
human equivalent of two cups of wild blueberries per day for eight weeks experienced a significantly improved inflammatory response.
To investigate this effect
in humans, Japanese scientists conducted a double - blind trial on
obese adults with similar body weights and waist measurements
in 2009.
17.07.2015 Weight - loss diet works better when combined with vitamin D 10.07.2015 Build muscle mass, increase endurance capacity and lose fat through intermittent fasting 01.07.2015 Superior weight - loss diet: high protein plus capsaicin supplements 22.05.2015 Why weight loss supplements with N - methyltyramine may not work 12.05.2015 Capsaicin keeps metabolic rate high during weight loss diet 09.05.2015 Lose fat faster with 2 g choline per day 05.05.2015 Aloe vera as a slimming supplement 03.04.2015 Daily glass of tomato juice makes you slimmer 28.03.2015 Body fat melts away with gum Arabic 16.03.2015 Burning fat with circuit training goes better with extra vitamin D 27.02.2015 Strict weight loss diet works better if you bend the rules occasionally 23.02.2015 Strength training fights belly fat better than aerobic training 19.02.2015 L - Carnitine makes fasting easier and more effective 03.02.2015 Weight - loss diet works better with three glasses of light soft drink a day 12.01.2015 GABA: body fat inhibitor and insulin booster 30.12.2014 Slimming effect of Green Coffee Bean: study was fake 14.11.2014 Bowl of low - fat yoghurt
in the afternoon makes dieting easier 27.10.2014
Obese teenagers benefit most from a combination of strength training and cardio 21.10.2014 Opuntia, the weight - loss cactus 18.09.2014 A year on a high - protein slimming diet is good for cardiovascular system 27.08.2014 Abgone slimming supplement doesn't work at all 23.08.2014 Exercise and low - carb diet combo excellent way to lose weight 20.08.2014 Lose weight with chlorophyll 14.08.2014 Lose weight and keep it off with quinoa 09.08.2014 Proof: stress makes you fat 03.08.2014 Weight loss: faster and healthier with 2 meals a day 30.07.2014 Cacao boosts fat burning 18.07.2014 L - Citrulline changes apple into pear 10.07.2014 How multi-vitamins can help you stay slim 07.07.2014 Lose weight without dieting with Gynostemma pentaphyllum 20.06.2014 Citrus extract Sinetrol reduces fat mass but increases lean body mass 14.06.2014 Lose four kg
in a couple of days: and keep it off a year later 25.05.2014 Diet with less sodium and more potassium has slight slimming effect 23.05.2014 Eco-Atkins: the Atkins diet, but then vegan 02.05.2014 DMAE as slimming supplement 21.04.2014 Daylight
in the morning has slimming effect 17.04.2014 The best high - protein slimming diet contains lots of taurine and glycine 13.04.2014 Lose weight three times faster with XLS Medical 31.03.2014 Strength training helps keep post-menopausal women slim 03.03.2014 Weight loss: half an hour a day of cardio works works better than an hour 18.02.2014 Swop your desk chair for a therapy ball, and keep slim 16.02.2014 Rapid weight loss without losing muscle: combine intermittent fasting and cardio 11.02.2014 Overweight people can best combine cardio and strength training 28.01.2014 Slimming supplement containing ECGC, resveratrol and Grape Seed Extract shown to work
in human study 12.01.2014 Weight - loss regime plus raspberry ketone - caffeine - capsaicin cocktail burns more fat and builds more muscle 06.01.2014 This is how the slimming vitamin biotin works 04.01.2014 High dose of biotin sabotages fat cell growth 01.01.2014
«National Survey data shows that the prevalence of overweight and
obese adults
in the U.S. has increased steadily over the past three decades», said Youfa Wang, MD, PhD, lead author of the study and associate professors with the Bloomberg School's Center for
Human Nutrition.
The study, published on Feb. 3
in the journal
Human Reproduction, found it may take couples
in which both partners are
obese up to 59 % longer to get pregnant compared to couples
in the healthy weight range.
Humans: Trials Using the Intermittent Very Low Energy Approach:
In overweight and / or obese populations, the majority of IER (60 - 85 % ER / alternate days) trials spanning four to 12 weeks have consistently demonstrated global improvements in cardiovascular risk markers, encompassing enhancements in glucose metabolism (described above) and lipid profiles 37 - 40, 42, 46, 49, 50 - 52 relative to baseline, which collectively would be expected to improve vascular functio
In overweight and / or
obese populations, the majority of IER (60 - 85 % ER / alternate days) trials spanning four to 12 weeks have consistently demonstrated global improvements
in cardiovascular risk markers, encompassing enhancements in glucose metabolism (described above) and lipid profiles 37 - 40, 42, 46, 49, 50 - 52 relative to baseline, which collectively would be expected to improve vascular functio
in cardiovascular risk markers, encompassing enhancements
in glucose metabolism (described above) and lipid profiles 37 - 40, 42, 46, 49, 50 - 52 relative to baseline, which collectively would be expected to improve vascular functio
in glucose metabolism (described above) and lipid profiles 37 - 40, 42, 46, 49, 50 - 52 relative to baseline, which collectively would be expected to improve vascular function.
concentrations
in normal - weight and
obese humans New England Journal Medicine 1996; 334: 292 - 295.
Leptin levels
in human and rodent: measurement of plasma leptin and ob NAN
in obese and weight - reduced subjects.
The great news is that by adding fermented veggies into your foods, you are changing your gut health for better: «the composition of the gut microbiota has been shown to differ
in lean and
obese humans and animals and to change rapidly
in response to dietary factors.
Altering the gut genome from
obese to lean has «long lasting effects» when combined with a «healthy diet high
in fiber and low
in saturated fats,» confirming multiple studies that show «that the food we eat has a direct relationship to the types of bacteria produced
in the
human digestive system;»
In the
human study,
obese people who lost weight increased their bacteroidetes, while the numbers of firmicutes decreased.
Two studies supporting this theory — one looking at mice, the other using
humans — found that a family of bacteria known as firmicutes was more plentiful
in the
obese (20 percent more), whereas another bacteria called bacteroidetes was almost 90 percent lower
in obese subjects.