Sentences with phrase «in obese mice with»

Reduced adiposity and improved insulin sensitivity in obese mice with antisense suppression of 4E — BP2 expression.

there is a 5-fold increase in number of insulin - secreting cells per islet in obese mice with high insulin secretion

By comparing the behavior of XBP - 1s in the obese mice with that in lean, healthy ones, he discovered an inflammatory protein that modifies XBP - 1s in healthy animals so it can be shuttled into the nucleus.

Not exact matches

In the case of the obese mice, Sinclair observes, resveratrol increased insulin levels while decreasing glucose levels, resulting in healthier liver and heart tissue when compared with obese mice that did not receive treatmenIn the case of the obese mice, Sinclair observes, resveratrol increased insulin levels while decreasing glucose levels, resulting in healthier liver and heart tissue when compared with obese mice that did not receive treatmenin healthier liver and heart tissue when compared with obese mice that did not receive treatment.

Scientists reached this conclusion by transferring microbes from bypass - treated obese mice to a group of lean mice raised in sterile conditions that left them with no intestinal bacteria at all.

Working together with Cedric Notredame (CRG) and Elena Martín - García (UPF), the scientists found that as well as becoming obese, the mice started very early to show the signs of addiction - like behaviour and binge - eating in response to these enticing foods.

With the risperidone, the mice become obese and exhibit an alternative, less healthy shift in their microbiome,» Kirby says.

«Importantly, we found that blocking the actions of the endocannabinoids with pharmacological inhibitors of cannabinoid receptors in the periphery completely normalized food intake and meal patterns in western diet - induced obese mice to levels found in control lean mice fed standard chow.»

The investigators also discovered that a potent suppressor of autophagy (called mTOR) was hyperactivated in the kidneys of obese mice, and treatment with an mTOR inhibitor ameliorated autophagy insufficiency.

The drug, SRT1720, kept mice with high - calorie diets from becoming obese or diabetic, according to a study published in Cell Metabolism [subscription required].

«Vaccines fail to protect obese mice from severe influenza infections: Fu vaccines with adjuvants don't work as well in obese mice.»

In one recent test, mice implanted with fecal microbes from thin humans stayed thin, while mice given bacteria from obese people gained weight.

Cohousing mice harboring an obese twin's microbiota (Ob) with mice containing the lean co-twin's microbiota (Ln) prevented the development of increased body mass and obesity - associated metabolic phenotypes in Ob cage mates.

Now Catherine Suter at Victor Chang Cardiac Research Institute in Sydney and her colleagues have investigated the longer - term effects of paternal obesity by mating obese male mice with lean females.

To explore that question, a team led by Cornell University biomedical engineer Claudia Fischbach first showed that female mice that were obese, because of genetics or a high - fat diet, had more fibrous mammary fat pads with straighter collagen fibers than those seen in lean mice (see image).

«The ease with which this weight loss was achieved in mice — even with continued caloric binging — is in stark contrast to the Herculean difficulties morbidly obese patients experience trying to preserve weight loss through dietary restraint,» adds Dr. Gendler.

Treating obese mice with catestatin (CST), a peptide naturally occurring in the body, showed significant improvement in glucose and insulin tolerance and reduced body weight, report University of California San Diego School of Medicine researchers.

To identify genes whose expression correlated with adiposity, we profiled gene expression in perigonadal adipose tissue from 24 mice in which adiposity varied due to sex, diet, and the obesity - related mutations agouti (Ay) and obese (Lepob).

Our results indicate that the percentage of macrophages in the adipose tissue that surrounds and infiltrates the extensor digitalis longus muscle is increased in obese mice compared with lean mice.

Adipose tissue within muscle contained significant numbers of F4 / 80 + macrophages, and the percentage of F4 / 80 + cells within this adipose tissue was markedly increased in obese mice compared with lean mice (41 % ± 4 % of macrophages vs. 12 % ± 2 % of macrophages, respectively; P < 0.005, mean ± SD)(Figure 4).

For example, we showed in collaborative work with Jeffrey I. Gordon's laboratory at Washington University in St. Louis last year that transferring the microbes from an obese person into mice raised in a bubble with no microbes of their own resulted in fatter mice.

The percentage of F4 / 80 - positive macrophages within this adipose tissue was markedly increased in obese compared with lean mice (e, P < 0.005).

In genetically programed insulin - resistant obese mice with increased appetite and reduced physical activity, targeted restoration of Pomc function only within 5 - hydroxytryptamine 2c receptor containing cells induces sex differences in energy balance (267In genetically programed insulin - resistant obese mice with increased appetite and reduced physical activity, targeted restoration of Pomc function only within 5 - hydroxytryptamine 2c receptor containing cells induces sex differences in energy balance (267in energy balance (267).

In 2005, together with Washington University microbiologist Jeffrey Gordon and others, Knight used the tools to catalog the microbes that inhabit the intestines of lean and obese mice, in hopes of uncovering relationships between microbes and metabolic healtIn 2005, together with Washington University microbiologist Jeffrey Gordon and others, Knight used the tools to catalog the microbes that inhabit the intestines of lean and obese mice, in hopes of uncovering relationships between microbes and metabolic healtin hopes of uncovering relationships between microbes and metabolic health.

Another important experiment was done later, where they actually bred them across the mice that were knocked out in PTP1B, with mice that were obese, the so - called ob / ob background.

Studies in diet - induced obese (DIO) mice with IRAB - A reduced fed blood glucose and insulinemia yet impaired glucose tolerance and led to protracted insulinemia during a meal challenge.

Interestingly, it has been reported that mice with a mutation in Kap1 were obese and had behavioral problems, and the lower expression of Kap1 that we have found in the blastocysts produced by IVC could also be related to the behavior problem reported in mice generated by IVC [43].

Also, these mice were in far, far better shape than their obese counterparts with regular myostatin levels.

Aids in weight loss Microbe - free mice injected with bacteria from obese people gained weight while mice injected with bacteria from thin people did not.

Green tea -LRB--)- epigallocatechin -3-gallate reduces body weight with regulation of multiple genes expression in adipose tissue of diet - induced obese mice

In a later step of this study, microbiota from obese mice fed with a western diet were transferred to the microbiota - free mice.

In rodents, ketogenic diets reduce reactive oxygen species in the brain34 and reduce central inflammation and reactive oxygen species in a model of multiple sclerosis.35 Two clinical papers have found that ketogenic diet feeding of 12 weeks to 6 months reduced signs of liver inflammation in obese patients with nonalcoholic fatty liver disease (in addition to improving various other physiological and biochemical variables).36, 37 Unfortunately, basic research into non-alcoholic fatty liver disease has been hampered by species differences between mice and humans in their hepatic reaction to ketogenic diets.In rodents, ketogenic diets reduce reactive oxygen species in the brain34 and reduce central inflammation and reactive oxygen species in a model of multiple sclerosis.35 Two clinical papers have found that ketogenic diet feeding of 12 weeks to 6 months reduced signs of liver inflammation in obese patients with nonalcoholic fatty liver disease (in addition to improving various other physiological and biochemical variables).36, 37 Unfortunately, basic research into non-alcoholic fatty liver disease has been hampered by species differences between mice and humans in their hepatic reaction to ketogenic diets.in the brain34 and reduce central inflammation and reactive oxygen species in a model of multiple sclerosis.35 Two clinical papers have found that ketogenic diet feeding of 12 weeks to 6 months reduced signs of liver inflammation in obese patients with nonalcoholic fatty liver disease (in addition to improving various other physiological and biochemical variables).36, 37 Unfortunately, basic research into non-alcoholic fatty liver disease has been hampered by species differences between mice and humans in their hepatic reaction to ketogenic diets.in a model of multiple sclerosis.35 Two clinical papers have found that ketogenic diet feeding of 12 weeks to 6 months reduced signs of liver inflammation in obese patients with nonalcoholic fatty liver disease (in addition to improving various other physiological and biochemical variables).36, 37 Unfortunately, basic research into non-alcoholic fatty liver disease has been hampered by species differences between mice and humans in their hepatic reaction to ketogenic diets.in obese patients with nonalcoholic fatty liver disease (in addition to improving various other physiological and biochemical variables).36, 37 Unfortunately, basic research into non-alcoholic fatty liver disease has been hampered by species differences between mice and humans in their hepatic reaction to ketogenic diets.in addition to improving various other physiological and biochemical variables).36, 37 Unfortunately, basic research into non-alcoholic fatty liver disease has been hampered by species differences between mice and humans in their hepatic reaction to ketogenic diets.in their hepatic reaction to ketogenic diets.38

in 2016, genetically identical mice that consumed a high - fat diet were more likely to produce obese offspring with impaired glucose tolerance, an early sign of type 2 diabetes.

All we have to go on is preclinical data in mice (and many of these mice are obese and raised in crowded cages6), and we must remember this, especially with patients and their families who are at wit's end because they are unable to effectively follow the diet.

In the first group, they colonized the mice's intestines with flora from an obese cage mate.

Activity through play is most effective with obese cats as, in addition to burning calories, it increases muscle mass, increases resting metabolic rate, improves mobility and mental stimulation, and often improves the cat — owner bond.10 Owners should be encouraged to increase their cat's activity level at home gradually, based on its needs, starting with 5 to 10 minutes per day of low - intensity activities for sedentary pets (e.g., walking).22 Creativity in activities, such as incorporating food - dispensing toys, placing meals in different parts of the house, and using interactive toys, laser pointers, and electronic mice can also be helpful with a long - term weight loss program.22 Any increase in physical activity is likely beneficial for a cat of any weight.