Sentences with phrase «in old mice»

In a mice experiment, the amount of brown fat cells in older mice was maintained at almost the level equivalent to that of younger mice.

The compound increased bone tissue in the older mice and prevented age - related bone loss.

Previous studies found better muscle health and stronger healing in old mice receiving blood from a younger counterpart.

The function of nerve cells, or neurons, also improved in the old mice receiving the mixed blood.

Additional experiments showed that the vaccine was durable, effective for at least 6 months, and that it worked well in older mice.

Moreover, reducing the number of receptors improved memory in older mice that often have memory deficits.

The reduced numbers of bacteria and white blood cells resulted in less lung damage in the older mice who received extra vitamin E.

They found that while treatment improved young mice, it did not make a noticeable difference in the older mice.

The study noted a significant negative effect of low protein diets in older mice.

«After his experiments demonstrated improvements in memory and «rejuvenation» in the brain in old mice with young blood, we thought to try a small, phase one trial, in patients.»

Researchers have shown that THC in marijuana alters the structure of the brains in older mice to be more like brains of younger mice.

«This well - designed set of experiments shows that chronic THC pretreatment appears to restore a significant level of diminished cognitive performance in older mice, while corroborating the opposite effect among young mice,» wrote Susan Weiss, director of the Division of Extramural Research at the National Institute on Drug Abuse, who was not involved in the study, in an e-mail.

By contrast, in older mice set the same tasks, the acetyl cap was missing and no boost in gene activity occurred during learning.

More recently the team took a closer look at the microglia in the older mice.

«The process, known as heterochronic parabiosis, managed to reverse hypertrophy in the older mouse after just four weeks,» says Lauer.

Finch showed that TAT gene expression is reduced in old mice relative to young mice; however, when he injected glucocorticoids directly into old and young rodents, he found no age - associated impairment in their responses.

The researchers then confirmed that the number of singly paired chromosomes — also called univalents — was higher in older mouse and even human egg cells, indicating that age - related segregation errors could be tracked back to increased numbers of prematurely separated chromosome pairs.

«Simply by counting cell types, we immediately saw that there were more Tregs in the older mice with diabetes than any other group.»

Imbalances in the composition of gut microbes in older mice cause the intestines to become leaky, allowing the release of bacterial products that trigger inflammation and impair immune function.

In further studies by other researchers, infusions of young blood made broken bones in old mice heal better (SN Online: 5/19/15), gave their muscles extra spring and improved their memories (SN: 5/31/14, p. 8).

«I believe there's still some very important pre-clinical work we need to do, including understanding why GDF11 is lost with age, and whether there is counter-regulation of it that may develop in older mice,» she says.

Muscle fibres in old mice injected with GDF11 doubled in size to match that of 2 - month old mice.

Besides the reduced numbers of helper T cells in the DLNs, the researchers also found that the lymph node environment in older mice contained lower levels of immune stimulators (so - called chemokines) and therefore was less capable of attracting other immune cells necessary for germinal center formation.

Then an experiment in 2005 found that young blood returned the liver and skeletal stem cells of old mice to a more youthful state, and work in 2012 discovered that young blood can reverse heart decline in old mice.

This may help explain why a study last year by a different company, Alkahest, found that heart health improved in old mice given blood from human teenagers.

Knox is now testing whether the strategy is as effective at reactivating stem cells and regenerating damaged tissue in old mice as it is in young mice.

23: Smithey MJ, Renkema KR, Rudd BD, Nikolich - Žugich J. Increased apoptosis, curtailed expansion and incomplete differentiation of CD8 + T cells combine to decrease clearance of L. monocytogenes in old mice.

BUFFALO, New York, July 6, 2016 — A research team from Everon Biosciences, Inc. and Roswell Park Cancer Institute has identified a specific subpopulation of immune cells accumulating in old mice that are likely contributors to aging and age - related diseases.

The success of the treatment in older mice, which corresponded to late adulthood in humans, is particularly important, as this would be the age that would be targeted were this method ever to be used therapeutically in people.

Researchers at Oxford have demonstrated that autophagy is diminished in T cells from aged mice, and T cell responses could be boosted in older mice using the autophagy - inducing compound spermidine.

Buck Institute scientist Julie Andersen, Ph.D., an expert in Parkinson's, has also observed positive effects of low - dosage lithium in older mice having a Parkinson's mutation, suggesting more research is warranted to see if it can help humans with the disease.

Kandel set out to determine whether osteocalcin could also reverse memory loss in older mice.

«Something — or some things — in the blood of young mice has the ability to restore mental capabilities in old mice, a new study by Stanford University School of Medicine investigators has found.

The lack of effect of exercise on progranulin in older mice is similar to the pattern of exercise effects on hippocampal BDNF, which also decrease with age (Adlard et al., 2005a; van Praag et al., 2005).

By doing so, they found that the influx of certain immune cells, called macrophages, from the young mouse helped resident stem cells restore effective remyelination in the old mouse's spinal cord.

For that purpose, 21 - to 23 - month - old mice were treated with daily injections of either recombinant GDF11 (rGDF11, 0.1 mg / kg mouse body weight), a dosing regimen that increases GDF11 levels in old mice toward youthful levels (13), or phosphate - buffered saline (PBS)(vehicle) for 4 weeks, and their blood vessels were subsequently analyzed by using the volumetric assay described above.

Young blood induces vascular remodeling and increases blood flow in old mice.

The net effect of deleting the adiponectin gene in mice is to produce higher bone mass in young mice and lower bone mass in older mice.

Research in mice has shown promise that increased NAD + levels can «turn back the clock» and make muscles, organs and tissues in older mice resemble that of much younger animals (3).

Yet while alpha cells can reprogram into insulin production also in old mice, the ability of delta cells to do so is limited and does not extend beyond puberty.

The researchers found that low doses of THC appeared to improve both memory function and markers of brain cell function in old mice.

To their surprise, they found that when old and young mice were joined, the muscle stem cells in old mice were revitalized.

The team also found that in older mice, the cells surrounding the egg produced fewer feeding tubes.