Sentences with phrase «in older mice»

The study noted a significant negative effect of low protein diets in older mice.

Muscle contraction tests caused the branched fibers to rupture, or tear apart, in the older mice.

The active ingredient THC appears to restore brain function in older mice to similar levels seen in young mice.

This is explained by another finding from the Karsenty lab: circulating levels of osteocalcin are much higher in younger mice than in older mice.

The lack of effect of exercise on progranulin in older mice is similar to the pattern of exercise effects on hippocampal BDNF, which also decrease with age (Adlard et al., 2005a; van Praag et al., 2005).

Kandel set out to determine whether osteocalcin could also reverse memory loss in older mice.

Buck Institute scientist Julie Andersen, Ph.D., an expert in Parkinson's, has also observed positive effects of low - dosage lithium in older mice having a Parkinson's mutation, suggesting more research is warranted to see if it can help humans with the disease.

Researchers at Oxford have demonstrated that autophagy is diminished in T cells from aged mice, and T cell responses could be boosted in older mice using the autophagy - inducing compound spermidine.

The success of the treatment in older mice, which corresponded to late adulthood in humans, is particularly important, as this would be the age that would be targeted were this method ever to be used therapeutically in people.

The compound increased bone tissue in the older mice and prevented age - related bone loss.

The reduced numbers of bacteria and white blood cells resulted in less lung damage in the older mice who received extra vitamin E.

Besides the reduced numbers of helper T cells in the DLNs, the researchers also found that the lymph node environment in older mice contained lower levels of immune stimulators (so - called chemokines) and therefore was less capable of attracting other immune cells necessary for germinal center formation.

Imbalances in the composition of gut microbes in older mice cause the intestines to become leaky, allowing the release of bacterial products that trigger inflammation and impair immune function.

«Simply by counting cell types, we immediately saw that there were more Tregs in the older mice with diabetes than any other group.»

The team also found that in older mice, the cells surrounding the egg produced fewer feeding tubes.

Additional experiments showed that the vaccine was durable, effective for at least 6 months, and that it worked well in older mice.

«This well - designed set of experiments shows that chronic THC pretreatment appears to restore a significant level of diminished cognitive performance in older mice, while corroborating the opposite effect among young mice,» wrote Susan Weiss, director of the Division of Extramural Research at the National Institute on Drug Abuse, who was not involved in the study, in an e-mail.

Yet while alpha cells can reprogram into insulin production also in old mice, the ability of delta cells to do so is limited and does not extend beyond puberty.

Previous studies found better muscle health and stronger healing in old mice receiving blood from a younger counterpart.

To their surprise, they found that when old and young mice were joined, the muscle stem cells in old mice were revitalized.

The researchers then confirmed that the number of singly paired chromosomes — also called univalents — was higher in older mouse and even human egg cells, indicating that age - related segregation errors could be tracked back to increased numbers of prematurely separated chromosome pairs.

Beta - catenin levels were much lower in old mice that had received young blood, suggesting that a molecule present lowers beta - catenin and promotes bone growth.

Muscle fibres in old mice injected with GDF11 doubled in size to match that of 2 - month old mice.

Then an experiment in 2005 found that young blood returned the liver and skeletal stem cells of old mice to a more youthful state, and work in 2012 discovered that young blood can reverse heart decline in old mice.

«MitoQ completely restored endothelial function in the old mice.

This may help explain why a study last year by a different company, Alkahest, found that heart health improved in old mice given blood from human teenagers.

Nearly a decade ago now, researchers demonstrated restoration of more youthful levels of liver function in old mice by adding a duplicate gene to increase amounts of this protein.

This new study investigates this in old mice showing signs of age - related worsening of memory function.

* «A chronic low dose of ∆ 9 - tetrahydrocannabinol (THC) restores cognitive function in old mice» by Bilkei - Gorzo et al. will be published in Nature Medicine on Monday 8th May.

BUFFALO, New York, July 6, 2016 — A research team from Everon Biosciences, Inc. and Roswell Park Cancer Institute has identified a specific subpopulation of immune cells accumulating in old mice that are likely contributors to aging and age - related diseases.

«Something — or some things — in the blood of young mice has the ability to restore mental capabilities in old mice, a new study by Stanford University School of Medicine investigators has found.

By doing so, they found that the influx of certain immune cells, called macrophages, from the young mouse helped resident stem cells restore effective remyelination in the old mouse's spinal cord.

«After his experiments demonstrated improvements in memory and «rejuvenation» in the brain in old mice with young blood, we thought to try a small, phase one trial, in patients.»

To investigate the relationship between JAK / STAT and p53 signaling, we challenged HSCs with a constitutively active form of JAK2 (V617F) and observed an expansion of the p53 - positive subpopulation in old mice.

For that purpose, 21 - to 23 - month - old mice were treated with daily injections of either recombinant GDF11 (rGDF11, 0.1 mg / kg mouse body weight), a dosing regimen that increases GDF11 levels in old mice toward youthful levels (13), or phosphate - buffered saline (PBS)(vehicle) for 4 weeks, and their blood vessels were subsequently analyzed by using the volumetric assay described above.

Young blood induces vascular remodeling and increases blood flow in old mice.

In old mice, FMD cycles promoted brain growth (hippocampal neurogenesis), which would be a nice thing to have happen in humans!

Gene therapy in old mice has been shown to cause to a 27 % increase in strength, along with regeneration of aging muscle.

Not exact matches

(And, as with the mouse who gets stuck in that old - fashioned spring trap, it must be kind of painful.)

We had mice in our old apartment a few times and it was so gross!

Maybe the experience of being at a lower division club and seeing older players busting a gut in a mickey mouse environment is enough to give our loanies the motivation and appreciation to succeed when recalled back to the Arsenal?.

Don't forget that Cech has won PL & CL trophies in his time at Chelsea and there was no way that he was going to let some of his old buddies take the mick out of him for lifting and celebrating some Mickey Mouse cup??

Some uninterrupted, non-educational (sorry, ABC Mouse) idiot box staring, just like in the good old days of our own TV - soaked Gen X childhoods.

The team found neonatal mice with the mutations had normal - appearing skin, and the dry itchy skin of dermatitis did not develop until the mice were a few months old, the equivalent of a young adult in human years.

I love that my older children have already met and fallen in love with my old friends such as Sense & Sensibility, The Great Gatsby, Moby Dick, Of Mice and Men, The Red Badge of Courage, War and Peace, The Hound of the Baskervilles, and so many, many more.

I worked with the American Cancer Society in the late 1980s through the 1990s and lived through the «more 6 - year - olds can recognize Joe Camel than Mickey Mouse» days.

My oldest son made me one of these when he was in grade school, except his was a sleeping mouse.

As for me, when I get to that voting booth I may have to fall back on that old reliable write in favorite, Mickey Mouse.

It's probably safe to say no D.J. played Modest Mouse at the uptown event, but white hair was still a hot accessory later in the night, as the older crowd gravitated towards the velvet couches (under the taxidermic animals) while younger bunches of volunteers, filmmakers, and tech consultants crowded the bars and would - be dance floor.

The scenario of hapless city slickers gamely trying to make a go of living in the country is an old classic, from Aesop's fable «The Town Mouse and the Country Mouse» and Shakespeare's As You Like It to Kaufman and Hart's 1940 play George Washington Slept Here and the»60s TV sitcom Green Acres.