Encoding predicted outcome and acquired value
in orbitofrontal cortex during cue sampling depends upon input from basolateral amygdala
Neural encoding
in orbitofrontal cortex and basolateral amygdala during olfactory discrimination learning
Finger EC, Marsh AA, Blair KS, Reid ME, Sims C, Ng P. Disrupted reinforcement signaling
in the orbitofrontal cortex and caudate in youths with conduct disorder or oppositional defiant disorder and a high level of psychopathic traits.
Matthew Boersma - «Anticipatory neuronal firing
in the orbitofrontal cortex in rats» (Advisor: S. Ramus)
Moreover, the study showed that at the time when the visual stimulus was presented, patterns of fMRI activity
in the orbitofrontal cortex encoded the identity of the odor that was expected.
Presumably, dopamine is released at the neuron's axon terminal
in the orbitofrontal cortex where it updates the identity information.
Further analyses showed that identity expectations
in the orbitofrontal cortex changed proportionally to the size of responses in the midbrain.
This is the first paper to show its role in encoding identity errors and how those are used to update expectations
in the orbitofrontal cortex.
When people drank fructose, the food images produced more activity
in the orbitofrontal cortex than when they consumed glucose.
The MRI scans showed that obese subjects with binge eating disorder have lower grey matter volumes — a measure of the number of neurons —
in the orbitofrontal cortex and striatum of the brain compared to those who do not binge eat; these brain regions are involved in keeping track of goals and rewards.
Subjects with the greatest reduction of the unpleasantness of the pain — which is what most people care about — exhibited the greatest activation of regions
in the orbitofrontal cortex and the largest reduction in the thalamus (gating the incoming sensory information).
Those with mutations had a significantly lower volume of grey matter
in their orbitofrontal cortex (Archives of General Psychiatry, vol 63, p 844).
One patch was
in the orbitofrontal cortex, which evaluates emotions and social behaviors.
Not exact matches
Some of the regions that process emotion are already present
in infants» brains at birth — the amygdala, hypothalamus, insula, cingulate
cortex, and
orbitofrontal cortex.
It turns out that if someone is actively craving cocaine, or if you expose an addict to stimuli that remind the addict of cocaine and activate the craving, what you are doing is increasing activity
in an area of the prefrontal
cortex called the
orbitofrontal cortex.
Previous work has suggested that the
orbitofrontal cortex (OFC), a part of the brain involved
in making predictions, might have a role
in decision confidence.
He also saw smaller
orbitofrontal cortices in obese individuals, important for impulse control and also involved
in feeding behaviour (Brain Research,
in press).
The scientists found that an area
in the lower frontal lobe, the so - called
orbitofrontal cortex, exhibited smaller volumes
in the healthy individuals that reported that they have problems with regulating emotions.
An additional comparison of this study group with adults with anorexia nervosa and a healthy control group supported greater
orbitofrontal cortex and insula volumes
in the disorder across this age group as well.
The deactivation of specific PFC regions significantly altered the performance of the animals: The inhibition of regions
in the infralimbic
cortex (IL) or the
orbitofrontal cortex (OFC) impeded the ability of the rats to react to external signals.
These insights support the hypothesis that the infralimbic
cortex and the prelimbic
cortex play an opposing role to that of the
orbitofrontal cortex: While the IL and the PL direct proactive behavior
in reaction to external signals, the OFC controls reactive behavior.
Redish and Steiner implanted minute electrodes into a brain region associated with regret
in monkeys and humans, called the
orbitofrontal cortex (OFC).
After an eight - minute training period, the subjects showed heightened levels of activity
in areas known to be part of the brain's reward circuitry, the amygdala and the
orbitofrontal cortex (OFC), associated with the pictures alone.
They found that compassion training increased activity
in the medial
orbitofrontal cortex and ventral striatum, areas associated with love and reward; empathy training increased activity
in the insula and anterior cingulate
cortex, typically involved
in registering another's pain.
Specifically, the degu pups raised without fathers had fewer synapses
in both the
orbitofrontal cortex and the somatosensory
cortex.
Researchers also used imaging techniques to look at two regions of the participants» brains — the insula and
orbitofrontal cortex — known to be involved
in salty taste.
This study is the first to demonstrate the involvement of the
orbitofrontal cortex in this process.
She found that 50 - minute cell phone calls increased metabolism
in the regions closest to the phone antenna — specifically, the
orbitofrontal cortex and temporal pole, which are involved
in sensory integration, language, decision making, and social and emotional processing.
We found enhanced activity
in the rostral anterior cingulate
cortex [rACC; MNI space coordinates (x, y, z): — 6, 41, 22; Z = 3.85; P < 0.0005] and medial
orbitofrontal cortex (mObfc; 6, 49, — 19; Z = 3.42; P < 0.0005), ventral anterior cingulate
cortex (vACC; 13, 32, — 14; Z = 4.56; P < 0.0005 uncorrected), and the vmPFC -LRB--- 4, 39, — 13; Z = 3.48; P < 0.0005).
The researchers think that a junk diet causes lasting changes
in the reward circuit parts of the rats» brain, for example, the
orbitofrontal cortex, an area of the brain responsible for decision - making.
It emerged that theta activity increased
in response to near - misses relative to other losses
in brain regions such as insula and
orbitofrontal cortex (OFC), which was linked to gambling severity.
Notable, areas
in the medial
orbitofrontal region and the anterior cingulate
cortex, which are relevant for self - referential appraisal and aesthetic judgments, were found to be activated during the listening.
Compared with healthy controls, those who had Tourette's exhibited more activity
in the premotor
cortex and cerebellum, regions that handle motor control, and less activity
in the striatum and
orbitofrontal cortex, areas involved
in decision making and learning.
For the imaging results, we discovered that positive reward was encoded
in the ventral striatum and negative reward elicited higher activity
in the lateral
orbitofrontal cortex.
Specialized value updating and goal selection areas
in the primate
orbitofrontal cortex.
Specifically, individuals diagnosed with major depression have smaller hippocampal and amygdala volumes (34,35), structural and morphological changes
in the prefrontal and
orbitofrontal cortex (22), and basal ganglia structures (6).
At least, that's what Kahnt knows now, based on his new Northwestern Medicine study about how neurons
in the midbrain encode errors
in our identity expectations and how the
orbitofrontal cortex updates them.
Claire Discenza - «Interactions between the hippocampus and
orbitofrontal cortex in rat long - term declarative memory» (Advisor: S. Ramus)
In humans, scientists have identified a region called the orbitofrontal cortex that is more active in OCD subject
In humans, scientists have identified a region called the
orbitofrontal cortex that is more active
in OCD subject
in OCD subjects.
In humans, the
orbitofrontal cortex is active during expressions of regret, and humans with damage to the
orbitofrontal cortex do not express regret.
While these decisions were being made, activity
in 3 brain areas was measured: the area where the pros and cons are weighed
in decision - making processes called the
orbitofrontal cortex; the area where generosity and prosocial behavior are processed called the temporoparietal junction; and the happiness associated area called the ventral striatum.
On the structural side, individuals who are perceived as having an online game addiction show significant gray matter atrophy
in various areas of the brain (right
orbitofrontal cortex, bilateral insula, and right supplementary motor area) once examined on brain MRI studies.
«When tired, participants showed greater brain activity
in two areas involved
in olfaction — the piriform
cortex and the
orbitofrontal cortex —
in response to food smells than they did when well rested.
Neural regions expressed
in human OCD include the
orbitofrontal cortex, the dorsolateral prefrontal
cortex, the anterior cingulate circuit, the basal ganglia and the thalamus [18] and also the amygdala [19].
Patients with damage to
orbitofrontal cortex, the amygdala, or both, are often vulnerable to scams, bad business deals, and exploitative relationships, a vulnerability that may be affected by deficits
in specific aspects of social cognition (45, 47).
Olfactory neuronal responses
in the primate
orbitofrontal cortex: Analysis
in an olfactory discrimination task
Conduct - disordered youth exhibit a decreased dopamine response to reward and increased risk - taking behaviors related to abnormally disrupted frontal activity
in the anterior cingulate
cortex (ACC),
orbitofrontal cortices (OFC), and dorsolateral prefrontal
cortex (DLPFC) that worsens over time due to dysphoria activation of brain stress systems and increases
in corticotropin - releasing factor (CRF).
For example, the uncinate fasciculus is a white - matter tract connecting the amygdala and neighbouring anterior temporal lobe with the
orbitofrontal cortex and it thus may be involved
in facilitating empathy, emotion regulation and socio - cognitive processes [150].
Orbitofrontal cortex tracks positive mood
in mothers viewing pictures of their newborn infants
In the following sections we will review structural and functional neuroanatomical evidence derived from healthy participants as well as those with aggressive behaviour (e.g. conduct problems, CD, ODD) for the key areas implicated here (
orbitofrontal and dorsomedial prefrontal
cortex, insula, cingulate
cortex, amygdala).