«This puts the existing U.S. bladder cancer approval in serious doubt, and will also, of course, raise market concerns about Tecentriq's
efficacy in other cancer types,» Kepler Cheuvreux analyst David Evans wrote in a note to investors.
The Lund researchers have already started new studies in which a larger number of women will be monitored from breast cancer diagnosis and onwards, as well as testing ctDNA
methods in other cancer types.
Many questions remain, and Straussman and his group are now asking whether bacteria may be
found in other cancer types and, if so, what effects they might have on the cancer and its sensitivity to other anti-cancer drugs including a novel family of immune - mediated anti-cancer drugs.
It will, therefore, be very interesting and potentially promising if similar effects are
seen in other cancer types, such as lung cancer,» Balkwill noted.
Using Epiviz and Bioconductor, the research team found consistent regions of DNA methylation changes in colon cancer samples generated by the public Cancer Genome Atlas project and similar gene expression in these regions of DNA methylation
changes in other cancer types.
«While there is understandable excitement around new therapies that enlist the immune system to fight cancer, we are still in a situation where greater than half of patients don't respond in melanoma and the response rate is even
worse in other cancer types,» Hanks said.
For this purpose, the researchers used the computational tool IMPACT, developed in the Tan lab, to sort functional from missense mutations and to cross-reference candidate mutations with those previously
reported in other cancer types.
Velculescu, Anagnostou, Smith and their colleagues say they plan to determine how broadly this phenomenon
occurs in other cancer types and potentially use it to develop new ways to improve current cancer immunotherapies.
Confirmation of the
biomarkers in other cancer types will facilitate further characterization and validation to provide mechanistic understanding of how and why these specific gene - targets become modulated to accentuate or inhibit tumor metastasis.
«The next step of our work will see how this approach
works in other cancer types, and we hope it could ultimately lead to testing this technique in trials to see if it can help patients.»
For example, HPV - inactive tumors were 17 times more likely to contain TP53 gene mutations — which are
common in other cancer types — than HPV - active cervical cancers.
«This heralds a new era in cancer treatment which is potentially revolutionary as it is likely similar techniques can be
used in other cancer types.